IGF-1 for Central Nervous System Repair?

[sanguine]

Hello, I am interested in researching the potential role IGF-1 can play in the repair of central nervous system myelin lesions/inflammation, specifically in the cervical spinal cord.

I have noticed there are a great variety of IGF forms and derivatives; do they all effect the same tissues equally, or are some more aimed at muscle tissue, nervous tissue, or anything like that?

There is a great deal of basic science showing that IGF can possibly help with these issues, especially myelin regeneration, and I want to study the peptide that will exhibit this pariticular aspect of IGF-1 the most. I realize this is a nuanced question and I will be doing my own scanning of the literature in the meantime.


Thanks for any help,
Sam

 

[GLHF]

Are u trying to repair an injury ?

I have asked that question before to a few doctorates and they all say there is hope for CNS recovery by igf like peptides. Only ur peripheral ns used igf to regenerate. Ur cns does not. There are new very exciting new peptides thy are similar to igf but made for the cns. U can still try but I can't see how ur going to target a SPECIFIC nerve with igf.

Watch out Man U dnt wanna go site injecting in ur spine.

 

[harbonah]

I cant contribute much to this as I have not really looked at IGF-1 in relation to your issue but, From my reading you might want to also look into Naltrexone. I am assuming this is related to multiple sclerosis?

 

[sanguine]

I cant contribute much to this as I have not really looked at IGF-1 in relation to your issue but, From my reading you might want to also look into Naltrexone. I am assuming this is related to multiple sclerosis?

That is the question at the moment; I have one mysterious lesion on my cervical spine and my doctors cant exactly figure out what it is. Ive been worked up for MS, obviously, and my cerebrospinal fluid seems normal; none of the typical markers of MS are present. Also, my brain is normal. So basically a diagnosis has been elusive. Whats known for sure is that I do indeed have a hyper intense signal on my C spine, indicative of inflammation and such.

My doctors have decided to watch and wait for now and are offering no treatment of any kind, aside from a 25 day stint on corticosteroids during august that didnt seem to do much if anything.


To GLHF: Are you sure about the peripheral vs central thing? I have been able to find plenty of studies that seem to suggest IGF-1 does in fact play a role in spinal cord myelination. Care to elucidate anymore on what your doctor friends have told you? What are some of these other peptides you mention?

EDIT: What about growth hormone releasing peptides? Those presumably would be able to convey all the possible benefits of both GH and IGF right? GH itself seems to have some myelin/CNS repair potential.
Thanks,
Sam