For me quite fast, after 2 weeks and improvement starts , but that's only improvement and doesn't mean it's fully gone as it takes sometimes months for that. Don't give up , accu helps guaranteed. When I used it got really depressed cause I thought it's not gonna work at all , depression could have been a side effect or it could have been both witch I'm more inclined to believe so keep that in mind. But depression definitely went away as soon as face started look to better from acne.