Robboe said:Apples and oranges.
TTA is not an oxidative uncoupler like DNP. It activates the uncoupling protein (UCP) family.
FENRIR said:Thanks Robboe, but do they have similar effects as far as the end results go?
What is the main diff in UCP and Oxidative Uncouplers?
Thanks!
some website said:Back in the 1930s DNP was touted as an effective diet pill. Indeed, the uncoupling of electron transport from ATP synthesis allows rapid oxidation of Krebs substrates, promoting the mobilization of carbohydrates and fats, since regulatory pathways are programmed to maintain concentrations of those substrates at set levels. Since the energy is lost as heat, biosynthesis is not promoted, and weight loss is dramatic. However, to quote Efraim Racker (A New Look at Mechanisms in Bioenergetics, Academic Press, 1976, p. 155), ..."the treatment eliminated not only the fat but also the patients,...This discouraged physicians for awhile..."
FENRIR said:Thanks Robboe, but do they have similar effects as far as the end results go?
What is the main diff in UCP and Oxidative Uncouplers?
Thanks!
some website said:Back in the 1930s DNP was touted as an effective diet pill. Indeed, the uncoupling of electron transport from ATP synthesis allows rapid oxidation of Krebs substrates, promoting the mobilization of carbohydrates and fats, since regulatory pathways are programmed to maintain concentrations of those substrates at set levels. Since the energy is lost as heat, biosynthesis is not promoted, and weight loss is dramatic. However, to quote Efraim Racker (A New Look at Mechanisms in Bioenergetics, Academic Press, 1976, p. 155), ..."the treatment eliminated not only the fat but also the patients,...This discouraged physicians for awhile..."
FENRIR said:Thanks Robboe, but do they have similar effects as far as the end results go?
What is the main diff in UCP and Oxidative Uncouplers?
CDB said:I believe TTA achieves a similar effect on the UCPs without actually disrupting the mitochondria's function.
Robboe said:No, DNP is unmatched by anything.
UCP family are responsible for stuff such as shivering etc. They waste calories to generate heat. Well, UCP2 does anyhoo.
Uncoupling by DNP basically involves short-circuiting the fat oxidising pathway your your body cranks it up by a metric ass-load.
Beowulf said:I've been running MP for about a week now, at 9 caps per day. I have been drenched n sweat every night. I asked my wife if the new sheets were making her sweat. She looked at me like :wtf: So I assume this is the MP at workI can't say I notice much difference in the mirror, but then again, I shouldn't I'm off for a week or so, and the water retention subsides.
Seems to be working, though.
Robboe said:TTA does effect the mitochondrias. It causes what scientists refer as mega-mitochondria or super-mitochondria, i forget which. These are like x10 the size of usual mitochondria. It also signals to increase the enzymes the mitochondria need to burn fat.
It also induces proliferation of peroxisomes (increases their number) by PPARalpha activation.
3clipseGT said:Damn bro 9 a day? I was on the beta version at 8 a day and can agree with you here, id be sweating just sitting.
Im on the reg version at 6 a day, i tried 8 a day and cramping go to bad, but with 6 a day i dont feel ish really, no heat, no nothing really. Should i up it to 7?
3clipseGT said:Just outa curiosity, at 6 caps a day for the rec. dosage , how much do you beleive it would raise baseline metabolic rate? More then clen? 15%? Just curious, i know DNP is like 30%
Robboe said:There's a study in rats showing a 20% rise, but i dunno what this equates to in humans.
Really though, i'm not too concerned. "metabolic rate" is more to do with overall calories burned, which doesn't specifically refer to fat oxidisation.
WannaGro said:Can anyone answer the earlier post about comparison to clen because right now I'm cutting, with a CKD diet and ECA, and will switch to clen this weekend. I love ECA, but the clen kind of cramps my calves really bad and makes me to jittery(I love the other effects though). If I could get a similar effect without the jitters, and maybe less cramping that would be great. MP doesn't make you jittery right? That was my understanding at least.
Thanks
-WannaGro
3clipseGT said:Yea true, im just makin sure im eating pretty clean and doin my cardio. Still seems better for me then ephedrine tho or anything else for that matter. Does MP taper down with use tho? Does the body become used to it? Reason im asking is because on the beta at 8 a day i swear i looked leaner everyday until i started holding water and then i just stayed at that leanness until i came off. Maybe now im holding water almost right away but it doesnt seem to be doin anything.
WannaGro said:Can anyone answer the earlier post about comparison to clen because right now I'm cutting, with a CKD diet and ECA, and will switch to clen this weekend. I love ECA, but the clen kind of cramps my calves really bad and makes me to jittery(I love the other effects though). If I could get a similar effect without the jitters, and maybe less cramping that would be great. MP doesn't make you jittery right? That was my understanding at least.
Robboe said:Nah, no need to taper MP use. By all means cycle the dose by a few caps either way if you get cramping and want it to subside without totally coming off the product.
I've not read anything about the body becoming accustomed to it.
The water retention can be quite horrendous and really does obscure a lot of the body recompositioning changes until you come off and let the water come off too.
Max32 said:yeah rob, the water retention still has me holding onto the initial batch of betas from months ago, lol. I am a very VISUAL person. Also, the fever blisters that some reported had me a little spooked. It may have just been a bad reaction or something, or they just got sick, who knows....