Here some info i pulled off my old computer...
"The structure of Boldione(unmethylated dione version of M14ADDiol, the methyl would allow more to be used) however is intrinsically resistant to 17-ketosteroid deactivation during this first pass through the liver. The combination of its delta 1 and delta 4 double bond (1,4-Di Ene) shifts the hepatic metabolism (the 17-keto redox potential) of this compound far in favor of activation. This is made clear by studies showing Boldione to produce by far the most profound excretion of active 17beta-hydroxysteroids we have seen of any prohormone, as much as 50% of recovered urinary metabolites [1] . Surprisingly the 17beta-hydroxyl group survives hepatic metabolism to an enormous degree."
[1] Metabolism of 1-dehydroandrostanes in man. I. Metabolism of 17-beta-hydroxyandrosta-1,4-dien-3-one, 17-beta-cyclopent-1-enyloxyandrosta-1,4-dien-3-one (quinbolone) and androsta-1,4-dien-3-one (1). Galletti F and Gardi R. Steroids 18 (1971) 39-50.
[2] Metabolism of 1-dehydroandrostanes in man. III. Metabolism of 17-beta-hydroxy-5a-androst-1-en-3-one, 17-beta-(1-methoxy-cyclohexyloxy)-5-a-androst-1-en-3-one (mesabolone) and 5a-androst-1-en-3,17-dione. Galletti F and Gardi R. J Steroid Biochem 3 (1972) 933-6. [3] Biosynthesis of Estrogens, Gual C, Morato T, Hayano M, Gut M and Dorfman R. Endocrinology 71 (1962) 920-25
[4] Aromatization of androgens to estrogens mediates increased activity of glucose 6-phosphate dehydrogenase in rat levator ani muscle. Endocrinol 106(2):440-43 1980
[5] The pentose phosphate pathway in regenerating skeletal muscle. Biochem J 170: 17 1978
[6] Activation of the somatotropic axis by testosterone in adult males: Evidence for the role of aromatization. Weissberger and Ho. J Clin Endocrinol Metab 76 (1993) 1407-12.
[7] Modulation of the cytosolic androgen receptor in striated muscle by sex steroids. Rance, Max. Endocrinol 115 (1984) 862-6
[8] Metabolism of Beldenone in Man: gas Chromatographic/Mass Spectrometric Identification of Urinary Excreted Metabolites and Determination of Excretion Rates. Schanzer, Donike. Bol Mass Spec. 21 (1992) 3-16
[9] Identification of C19 Steroids in Bovine Feces. Miller, W.R., C.W. Turner, D.K. Fukushima and I.I. Salamon: J. Biol. Chem. 1956 220: 221
[10] The in-vitro metabolism of progesterone-c14 to Delta-1,4-Androstadiene-3,17-dione by a cystic bovine ovary. Gawienowski A. M., Lee S.L. and Marion G.B.: Endocrinology 69 (1961) 388-90.
[11] C. J. M. Arts, R. Schilt, M. Schreurs and L.a. Van Ginkel, in Proceedings of the Euroresidue III Conference, Veldenhoven, 6-8 May 1996 ed. N. Haagsma and A. Ruiter, University of Utrecht, Utrecht, The Netherlands, 1996, p. 212