Hidden factor effecting SHBG

[The Matrix]

After years of research as well as looking into the hidden mechanism for SHBG, I have found one that has gone highly over looked. Through research we found that genetic expression with Cyp1a1 or Cyp2a1 are more liking to be expressive in people with fungal or mold issues. Many people are thinking "I do not have mold" well guess what the amount of MARCONS and nasal fungus being found on nasal swabs will blow your mind. After looking through numerous cases, who have high SHBG with out resolution of controlling it other ways resolved once the person was out of the moldy environment. This does not go for just males, but also many female doctor's patients I have worked where there cycle was 30,40,45 days for years finally started to regulate once they where addressed with mold as well as the SHBG also dropped significantly One of the cases, mold was not at the home, but rather at the office where she has been working for 10 years, as health was slowly declining resulting in severe neurological conditions. When further history was explored and other coworkers were contacted they also where experiencing same issue thinking it was depression or something else. DIM we have found to be a potential mold anti-aromatase. There are studies to validate as soon as I get back to my computer then I will post them for the Musclenerds here. If you have high SHBG with normal e2 or elevated e2 may want to think out side the box and more to your environment to how it is effecting your genetic expressions. DIM can also lift Nrf2 block which can help glutathione SOD and other antioxidants to work more effectively.

 

[The Matrix]

The body will release protein in an Inflammatory response as well as histamines. I have in a few cases seeing lowering histamines helped e2 symptoms in males. Histamines increase estrogen in females and estrogen increase histamine. If this is true in males no studies to confirm.

 

[Mr.TT]

Interesting.... I have consistently high normal SHBG, 50's - 70's (22-77 range). As a result of this highish SHBG, my TT is excellent, 700 plus, ( 250-1100 range), but my FT is at the bottom of range 50's (46 - 224 range). Because of my low FT, my E2 and DHT are also low in range.

I have tried and blood lab tested Stinging Nettles Root Extract, Winstrol, Danazol, and Anavar. The Oral Steroids all easily lowered my SHBG into the low 30's range. It only took .625mg / day ( 1/4 of a 2.5mg pill) of Anavar to cut my SHBG in half. Here is the problem. When my SHBG goes down, my HPTA lowers my TT and my FT remains always at the low end of range. I get nowhere.

I have DNA mutations on my DAO (diamine oxidase) genes. I am histamine intolerant. I can control my Mast Cells by avoiding high histamine foods and taking VitaminC, Histame(Daosin, etc.) and Quercitin.

Until this thread, I never considered a HISTAMINE reaction as a possible cause for my life long high SHBG. Thank You for a new line of thought and possible experimentation. I'm still thinking about how I can test this.

PS. I have noticed increased mast cell reactions when Danazol boosted my E2 levels.

 

[The Matrix]

By lowering free estrogen you are creating more histamine in tolerance. DAO is also associTed with type 2 diabetes. You can use DAO supplements as I often recommend to control histamine reactions from foods. Even some guys notice decease of e2 symptoms by controling histamine intolerance. Some time if there is a sleep issue and I know histamine are not being broken down properly using anti-histamine solves the issue. Also need to look at HNMT as well in your genetic report as its a huge player in histamine response. So is IGE an indicator of how mast cells respond to an inflammatory response. When methylation is down regulated it's down for a reason same as your ferritin levels drop in a pathogen exposure. Sorry do not post much not enough time between traveling and collaborating on cases with doctors.

 

[Wagner83]

Interesting.... I have consistently high normal SHBG, 50's - 70's (22-77 range). As a result of this highish SHBG, my TT is excellent, 700 plus, ( 250-1100 range), but my FT is at the bottom of range 50's (46 - 224 range). Because of my low FT, my E2 and DHT are also low in range.

I have tried and blood lab tested Stinging Nettles Root Extract, Winstrol, Danazol, and Anavar. The Oral Steroids all easily lowered my SHBG into the low 30's range. It only took .625mg / day ( 1/4 of a 2.5mg pill) of Anavar to cut my SHBG in half. Here is the problem. When my SHBG goes down, my HPTA lowers my TT and my FT remains always at the low end of range. I get nowhere.

I have DNA mutations on my DAO (diamine oxidase) genes. I am histamine intolerant. I can control my Mast Cells by avoiding high histamine foods and taking VitaminC, Histame(Daosin, etc.) and Quercitin.

Until this thread, I never considered a HISTAMINE reaction as a possible cause for my life long high SHBG. Thank You for a new line of thought and possible experimentation. I'm still thinking about how I can test this.

PS. I have noticed increased mast cell reactions when Danazol boosted my E2 levels.

We are very similar in terms of lab results. I've been on lj100 (olympus labs) for a week and mood , energy and libido are way up, almost back to my good days years ago. I'd like to combine it with divanil!
This is very interesting by the way, I do have plenty of allergies and some form of asthma. I read somewhere that eating more fruits and enough proteins could help lower shbg as well.

 

[The Matrix]

I just had a female with progesterone toxicity from inability to metabolize it out of her system. The progesterone was stimulating estrogen receptors causing extreme inflammatory reactions and neurological symptoms. After moving to a low histamine diet adding DAO symptoms have decreased dramatically. Symptoms would flare up specific time of cycle worse then others. This appeared to be PDD but it was just all a huge hidden histamine response known of the multiple endocrinologist had an idea of ..

 

[Matthersby]

Matrix, it's pretty sad out here. The few years of reading on here I've done, having my raw genetic data analyzed by a clinical nutritionist, and then researching each snp, making adjustments in diet and supplementation. Just mentioning this to a few endo's and I get blank stares. "Ya, uh, well, uh, let's just get you on testosterone cream and radiate your thyroid and see how you feel in 90, mkay?"
-Never in my years working in healthcare have I met a group of specialist MD's with so much incompetence and indifference.

 

[The Matrix]

I have been working in collaboration with multiple doctors and clinics globally to help to try to help change the mind set with in the system. Thinking being met with resistance medical professionals are opening up. I just met an endocrinologist in Canada who was willing to talk with me as TRT appears to be not practice up there. I had a male who needed treatment which no other doctor was going to provide. I have also been looking at testing which can be done from any country as well as our own if prices of insurance keep going up to provide the proper evalaution at the most least prices.

 

[MacWanted]

Hi Matrix,

I have high SHBG and subsequence low Free T. My genetic report indicates that I have the gene for high SHBG. What can I do to lower it in a constant manner?

 

[The Matrix]

Find out what triggered expression which probably would be inflammation. Again one needs to look at history labs and other symptoms for overall clinical picture. Could also be medicines or other factors

 

[Cherrycoke]

Hi Matrix,

I have high SHBG and subsequence low Free T. My genetic report indicates that I have the gene for high SHBG. What can I do to lower it in a constant manner?

What is the name of the test/genetic report that shows you have the gene for high SHBG?

 

[The Matrix]

Its located in the 23andme health risk report.
You need to find out what is causing it to express. I have seen everything from mold, specific drugs, antibiotics, cellular estrogen dominance, to thyroid meds and lyme as well as other pathogens

 

[Cherrycoke]

Very interesting! Unfortunately where I live in Europe I cant order the health risk report from 23andme. Do you know if there is a similar test that can track the gene that I can get via my doctor? I'm a young female with very high above range SHBG (always had) and its very hard to find someone that knows anything about this subject (the doctors have no clue!) I need to find out what is causing it to express so I can get to the root of it and regain my health. I have my suspicions based on my bloodtests and symptoms but not quite sure yet what it is or if I'm missing out on something. Reading your posts you seem to know a lot about this topic regarding SHBG. Could you please PM me, since I'm new to this forum it says I'm not allowed due to few posts.

 

[The Matrix]

That means you either live in Norway or Denmark as their systems suck for testing. The best thing I recommend over seas patients to do is set up a PO BOX in the United States then they will forward it to you. Have a friend in U.K. or other country forward it to you. I have learned to jump through all the international red tape as majority of patients are in U.K. and other counties even in remote villages in Nepal. Where there is a will there is a way. We use Dutch hormone urine testing which can be easily shipped along with OAT to any where in Europe or the world. The
Moral of story there are always around the system. The funniest thing is patients have to mule supplements from Sweden to neighboring countries. Women have high SHBG due to estrogen issues mainly. One would need to look at history, labs, symptoms to determine the pathophysiology. I am working right now with an MD in Poland stricken with severe health issues and had to stop practicing a few years ago. She is rapidly improving and with next 6 months to a year will be back in practice and will be one of the most advance doctors in EU...

 

[Cherrycoke]

So If SHBG levels are too high naturally because of intracellular estrogen dominance, how can I lower it safely? I'm thin but hypothyroid (Hashimoto's, positive TPO-ab + TG-ab) and I should be on thyroid medicine but whenever I'm on it I start to feel worse due to the tremendous rise of SHBG. Does thyroid medication actually increase the free estrogen, drawing the tissue bound estrogens out of the tissue? How can one then excrete the estrogen out from the body? T4 meds make me really sick unfortanetly, T3 works a little better but is not perfect because it makes me aggressive in the long run and also my musclestrenght decreases a lot on it.

 

[The Matrix]

So If SHBG levels are too high naturally because of intracellular estrogen dominance, how can I lower it safely? I'm thin but hypothyroid (Hashimoto's, positive TPO-ab + TG-ab) and I should be on thyroid medicine but whenever I'm on it I start to feel worse due to the tremendous rise of SHBG. Does thyroid medication actually increase the free estrogen, drawing the tissue bound estrogens out of the tissue? How can one then excrete the estrogen out from the body? T4 meds make me really sick unfortanetly, T3 works a little better but is not perfect because it makes me aggressive in the long run and also my musclestrenght decreases a lot on it.

For cases in other countries I use the Dutch hormone test for evaluation of hormones as it is easily transported and provides accurate results.
This is the goto test in people in hard to reach places or when the system is being cooperative. As you increase SHBG you will lower free estrogen as well as the free testosterone. This cases need to be properly reviewed by a health specialists to look at underlying pathologies.

 

[Cherrycoke]

For cases in other countries I use the Dutch hormone test for evaluation of hormones as it is easily transported and provides accurate results.
This is the goto test in people in hard to reach places or when the system is being cooperative. As you increase SHBG you will lower free estrogen as well as the free testosterone. This cases need to be properly reviewed by a health specialists to look at underlying pathologies.

Got it! Never had the dutch test but have a lot of bloodtests taken. So are you a health specialist? Can you help me out?

 

[Mr.TT]

Can you describe what you mean by REALLY SICK? Did you know that T4 meds lower your circulating DAO and MAO levels? T4 and ENDOs almost killed me. It has a lot to do with DNA mutations and Histamine Intolerance.

 

[rtmilburn]

For cases in other countries I use the Dutch hormone test for evaluation of hormones as it is easily transported and provides accurate results.
This is the goto test in people in hard to reach places or when the system is being cooperative. As you increase SHBG you will lower free estrogen as well as the free testosterone. This cases need to be properly reviewed by a health specialists to look at underlying pathologies.

The Matrix is there a way to test for mold, in your body, without going to the doctor??? As Ive suspected that I have been exposed to mild for quite sometime

Also what is the time frame for recovery?

 

[The Matrix]

DAO Is driven by copper
Metformin inhibits DAO
Histamine issues are driven by dysbiosis and gi inflammation which can impact function of DAO. You also need to look at HNMT among other with in the histamine pathway. Too much histamines can slow down MAO A.

 

[The Matrix]

ERMI test would be the first suggestion
Can take months to years to clear out mold especially if it gets tissues. I collaborated with Dr Shoe maker MD all the time with cases that been dealing it with years. Even had few commit suicide from black mold that could be cleared fast enough. One time both children from a single mother with in the same year. It was heart wrenching, but this is daily reality for us. People often think I blows smoke, guess what this sh!t is reality more then one knows..

 

[The Matrix]

Goto biolabs.uk they have it there for people in EU. I am good colleagues with precision's medical director. Shes very knowledgeable when it comes to hormones. Probably one of the few I actuallly trust from a reseach based approach .

I am here to share relative information and my experience as many other. I am here not to solicit.

 

[Cherrycoke]

Can you describe what you mean by REALLY SICK? Did you know that T4 meds lower your circulating DAO and MAO levels? T4 and ENDOs almost killed me. It has a lot to do with DNA mutations and Histamine Intolerance.

No I had no idea about this. This info is really new to me, never investigated anything about DAO or MAO before.
Sad to hear, it almost killed me too because I thought I was going insane and it has been very scary since nobody around me seems to believe what I have been thru and still struggle with. On T4 meds it felt as if I was dying of toxification. Its a strange feeling to describe and my head/mind was foggy all the time, anxiety and depressed. It also gave me cherry angiomas, I noticed few strands of my dark hair turned to this copper colour. I got constipated, and this pain in a area under my right ribcage. Itchiness under my feet and also acne. Of course my SHBG was and still is superhigh because I cant seem to get it down even since it been almost a year off the meds . Latest testresults was 214 nmol/L ( ref.range 32-128). My estradiol was in the higher range and testosteron of course low. I have feelings of both estrogen deficiency and dominance at the same time which is worrying me. And I cant seem to put on any weight even though I'm hypothyroid. I regret the day I tried thyroid meds because my health/hormones is more messed up now than before.
May I ask how you managed your thyroid condition, have you tried T3 meds? And what is the solution being histamine intolerant and having a thyroid condition?

 

[Cherrycoke]

Goto biolabs.uk they have it there for people in EU. I am good colleagues with precision's medical director. Shes very knowledgeable when it comes to hormones. Probably one of the few I actuallly trust from a reseach based approach .

I am here to share relative information and my experience as many other. I am here not to solicit.

Appreciate it very much!
Ok, went to that website but it says a doctor/practitoner needs to order the tests. I need to find this
knowledgeable person who can help me, what is "precision" and that medical director, can you give me a name/website please for me to contact?

 

[The Matrix]

She can not help you as she is only director of the labs and talks to heath providers. That's just the way the lab is set up. Biolabs you can use any ones name for practitioner as they often send it to whom ever. Very laxed as many people just put even personal trainers as practioners. Lol

 

[Mr.TT]

Cherrycoke, how many mcg of T4 were you on when you had the bad reactions? If you were first on a lower dose, did you have less of a bad reaction?
For me, less that 100mcg of T4 was fine. Anything about 100mcg caused many bad reactions.
Yes, I have done the T3-only thing, It helped with the histamine problems, but, in 6 months I went from 185lbs to 155lbs, all lost muscle.
I don't know about " cherry angiomas", but I had vasodilation rashes on my cheeks and my throat from the histamine caused by the T4.

It took me years to figure out why I was harmed by T4, and to find a solution, that worked for me.....

 

[Cherrycoke]

She can not help you as she is only director of the labs and talks to heath providers. That's just the way the lab is set up. Biolabs you can use any ones name for practitioner as they often send it to whom ever. Very laxed as many people just put even personal trainers as practioners. Lol

Ok..I still need a doc/someone who can help me interpret labs and what treatment I would need to get well. It doesnt matter how knowledgeable I am myself, you are seldom your own best doctor.

 

[Cherrycoke]

Cherrycoke, how many mcg of T4 were you on when you had the bad reactions? If you were first on a lower dose, did you have less of a bad reaction?
For me, less that 100mcg of T4 was fine. Anything about 100mcg caused many bad reactions.
Yes, I have done the T3-only thing, It helped with the histamine problems, but, in 6 months I went from 185lbs to 155lbs, all lost muscle.
I don't know about " cherry angiomas", but I had vasodilation rashes on my cheeks and my throat from the histamine caused by the T4.

It took me years to figure out why I was harmed by T4, and to find a solution, that worked for me.....

I could only do 25-50 mcg, and that is considered a starting dose. But whenever I tried to up from 50 mcg, the toxic feeling got worse.
Do you know why T4 and not T3 I guess lowers DAO & MAO levels?

I would love to hear what solution has worked for you? And have you got back the muscles you lost while on T3? My strength is still very decreased and I have a lot of vascularity on my arms Unfortunately.

 

[The Matrix]

Need to look at underlying pathology not just at hormones..

 

[Mr.TT]

I could only do 25-50 mcg, and that is considered a starting dose. But whenever I tried to up from 50 mcg, the toxic feeling got worse.
Do you know why T4 and not T3 I guess lowers DAO & MAO levels?

I would love to hear what solution has worked for you? And have you got back the muscles you lost while on T3? My strength is still very decreased and I have a lot of vascularity on my arms Unfortunately.

T4 lowers the intestine's output of systemic DAO, for EVERYONE! What causes problems for a few of us is we have GENETICALLY lower DAO levels. Most people have so much extra DAO that when T4 lowers their DAO, they still have more than enough.

MY STORY, MY STORY.......
Even below 100mcg T4 caused me joint pain, if I ate beans or soy. (T4 + Phytoestrogen = joint inflammation)
At 100mcg of T4 , I still had a TSH above 4, and I developed multi-nodule thyroid goiter.
So, ENDO upped my T4 to 125mcg. All hell broke loose. My ears swelled shut, roof of my mouth itched like hell, hives on my forearms, vasodilation rashes on my cheeks and throat. I got depressed, but I think it was because ENDO, ENT, PCP, and ALERGIST were worthless.

I noted that foods high in Phytoestrogen and Histamine increased my itching. BENADRYL did nothing to help, but Klonopin, Zyrtec, vitamin C HELPED SOME. By now I felt I was dealing with a MASTCELL problem. The question was how would T4 trigger my mastcells.

I had to take Chewable vitamin C every 3 hours, so I looked into making LIPISOMAL vitamin C. You use lecithin, to make it, and lecithin contains
CHOLINE. I was unfamiliar with choline and researched it. My diet was not high in choline, so I picked up a choline supplement. Took it, and in three hours I felt better than I had for years. So, what the hell did choline do?

That sent me to the Phoenix Rising Web Site, 23ANDME DNA tests, SULFATE urine test strips, and learning about the Methylation Cycle.

Here is my untrained opinion about what caused and fixed my many many year problem with T4.

T4 lowered my DAO level to the point that I had inadequate DAO to keep up with my circulating histamine.
My cells were forced to utilize HNMT to methylate histamine. Therefor using up SAM and creating lots of homocysteine.
I have double mutations on my Transsulfuration pathway gene. It eats up homocycteine before the Methylation Cycle can regenerate it back into SAM.
I became UNDERMETHYLATED, and unable to neutralize histamine and calm my mastcells.

The reason Choline/TMG helped is, they drive a Methylation Cycle shortcut that converted homocysteine back into SAM before the Transsulfuration pathway enzyme could destroy it, thus increasing my SAM.

Before you can solve a problem, you must understand it.

My problem with T4 was controlled by;
Advoiding high phytoestrogen and histamine foods.
Taking NDT sublingually (natural desiccated thyroid, ERFA, NatureThroid, etc.) still keeping my supplemented T4 below 100mcg. My TSH is now below 1 and my thyroid nodules dissolved.
Taking 1 gram of Liposomal Vitamin C (ascorbic acid)
Taking 100mg of choline
Taking 500mcg sublingual MB12 (methylcobalamin)
Taking 100mcg molybdenum ( an upregulated Transsulfuration pathway uses lots of molybdenum)
Taking as much DAOSIN as needed. (supplementing DAO)

My DNA tests indicate that I do not have vitamin B6 or B9 issues.

 

[The Matrix]

DNA tests are not going to determine b6 or b9 issues. Functional tests willl. If you are zinc deficiency you will be functional b6 deficient become of lack of P5P. Genetic shows a probability not an absolute. Just because you have a gene it does not mean it's expressing. T4 will lower DAO as it will also impact adrenals functions which is necessary for proper copper metabolism due to ceruloplasmin release from the liver. When a person has a copper issue correcting adrenal status will help this situation to make copper more bioavailable. Sulfur strips are in accurate form of measurements sulfur levels. By addressing the aldehydes the cbs pathways is also addressed in the process.

In scientific literature choline is the back up folate. It is noted a choline deficiency makes a folate deficiency worse. Using PC in a state of dysbiosis can increase inflammtion as often seen clinically.

Hyper cell permeability can mimic mast cell activation.

 

[Mr.TT]

Sulfate strips can be used to indicate if you have a Transsulfuration pathway mutation, while you are waiting the two months it takes to get your DNA test results for a confirmation..

DNA tests are not going to determine b6 or b9 issues REALLY, did you forget what MTHFR is?

Not everyone is SIBO / Disbiosis / Leaky Gut /

 

[Mr.TT]

I could only do 25-50 mcg, and that is considered a starting dose. But whenever I tried to up from 50 mcg, the toxic feeling got worse.
Do you know why T4 and not T3 I guess lowers DAO & MAO levels?

I would love to hear what solution has worked for you? And have you got back the muscles you lost while on T3? My strength is still very decreased and I have a lot of vascularity on my arms Unfortunately.

I weight 175+ now, so yes I regained 20lbs of something other than fat.

T3 only, did not work well for anyone, that I know, who tested it. There was a great thyroid site populated by people who had problems with T4 only protocol. The site shut down a few years ago.

Brain cells use free T4, beside free T3. I don't know what having no blood level of T4 for a long time, would do to your mind.

How many mcg of T3 did you take a day? For how long?

Have you considered using NDT (ERFA)? Or taking as much T4 as you can tolerate and adding T3 until your TSH is where you want it?
( I am not a believer in NDT is better than synthetic, I use NDT because it is cheaper, it used to be able to ordered it without a script (legally), and the T4 to T3 ratio works for me .)

IMO.(I have no scientific evidence for this, but) splitting up your 50mcg T4 tablets, into 4 pieces and sublingual them over the day, might keep the T4 away from your intestines and first pass liver filtering. It may lower the suppression of DAO. Be warned, you will get a little more T4 into body if you sublingual it. If you add T3, I would also split it up and sublingual it over the day. This smooths out peaks in free (unbound) T3.

 

[Cherrycoke]

T4 lowers the intestine's output of systemic DAO, for EVERYONE! What causes problems for a few of us is we have GENETICALLY lower DAO levels. Most people have so much extra DAO that when T4 lowers their DAO, they still have more than enough.

MY STORY, MY STORY.......
Even below 100mcg T4 caused me joint pain, if I ate beans or soy. (T4 + Phytoestrogen = joint inflammation)
At 100mcg of T4 , I still had a TSH above 4, and I developed multi-nodule thyroid goiter.
So, ENDO upped my T4 to 125mcg. All hell broke loose. My ears swelled shut, roof of my mouth itched like hell, hives on my forearms, vasodilation rashes on my cheeks and throat. I got depressed, but I think it was because ENDO, ENT, PCP, and ALERGIST were worthless.

I noted that foods high in Phytoestrogen and Histamine increased my itching. BENADRYL did nothing to help, but Klonopin, Zyrtec, vitamin C HELPED SOME. By now I felt I was dealing with a MASTCELL problem. The question was how would T4 trigger my mastcells.

I had to take Chewable vitamin C every 3 hours, so I looked into making LIPISOMAL vitamin C. You use lecithin, to make it, and lecithin contains
CHOLINE. I was unfamiliar with choline and researched it. My diet was not high in choline, so I picked up a choline supplement. Took it, and in three hours I felt better than I had for years. So, what the hell did choline do?

That sent me to the Phoenix Rising Web Site, 23ANDME DNA tests, SULFATE urine test strips, and learning about the Methylation Cycle.

Here is my untrained opinion about what caused and fixed my many many year problem with T4.

T4 lowered my DAO level to the point that I had inadequate DAO to keep up with my circulating histamine.
My cells were forced to utilize HNMT to methylate histamine. Therefor using up SAM and creating lots of homocysteine.
I have double mutations on my Transsulfuration pathway gene. It eats up homocycteine before the Methylation Cycle can regenerate it back into SAM.
I became UNDERMETHYLATED, and unable to neutralize histamine and calm my mastcells.

The reason Choline/TMG helped is, they drive a Methylation Cycle shortcut that converted homocysteine back into SAM before the Transsulfuration pathway enzyme could destroy it, thus increasing my SAM.

Before you can solve a problem, you must understand it.

My problem with T4 was controlled by;
Advoiding high phytoestrogen and histamine foods.
Taking NDT sublingually (natural desiccated thyroid, ERFA, NatureThroid, etc.) still keeping my supplemented T4 below 100mcg. My TSH is now below 1 and my thyroid nodules dissolved.
Taking 1 gram of Liposomal Vitamin C (ascorbic acid)
Taking 100mg of choline
Taking 500mcg sublingual MB12 (methylcobalamin)
Taking 100mcg molybdenum ( an upregulated Transsulfuration pathway uses lots of molybdenum)
Taking as much DAOSIN as needed. (supplementing DAO)

My DNA tests indicate that I do not have vitamin B6 or B9 issues.

Thank you for a very thorough explanation. Since you mentioned it I have looked upp high/low histamine foods, and I have always been eating very high in the past. A lot of fruits (especially citrus) veggies, and fish and seafood/shellfish as my main protein source. Never gluten and seldom any dairy because I dont feel well on it and because my thyroid condition. When I was younger (and not on any thyroid meds) I didnt experience any histamine related issues but the last years have had a lot of problems with my sinuses and unexplained urticaria and itching, guess my tipping point was reached. What I also have been thinking is if histamin response is estrogen related, that it gets worse of it that is as we age.
When you say joint inflammation, did you experience lower back pain? And has this treatment lowered your SHBG to a more "normal" level? Do you feel well today? What kind of foods do you eat typical in a day? Have also had high homocystein levels that decreased when I started 1000 mcg sublingual Methylcobalamin. Trying to understand all of this, it is a lot to take in.

 

[Mr.TT]

Thank you for a very thorough explanation. Since you mentioned it I have looked upp high/low histamine foods, and I have always been eating very high in the past. A lot of fruits (especially citrus) veggies, and fish and seafood/shellfish as my main protein source. Never gluten and seldom any dairy because I dont feel well on it and because my thyroid condition. When I was younger (and not on any thyroid meds) I didnt experience any histamine related issues but the last years have had a lot of problems with my sinuses and unexplained urticaria and itching, guess my tipping point was reached. What I also have been thinking is if histamin response is estrogen related, that it gets worse of it that is as we age.
When you say joint inflammation, did you experience lower back pain? And has this treatment lowered your SHBG to a more "normal" level? Do you feel well today? What kind of foods do you eat typical in a day? Have also had high homocystein levels that decreased when I started 1000 mcg sublingual Methylcobalamin. Trying to understand all of this, it is a lot to take in.

FRESH fruit, FRESH vegetables, FRESH fish, bananas, Fresh tomatoes from my garden, are not histamine problems for me. Canned tomato sauce. Wine, leftover fish, DRIED fruit, salami / pepperoni, will trigger itchiness. I live on the edge of MAST CELL Activation. A slice of pepperoni pizza and a glass of wine and three hours later I know that I have more histamine than I can neutralize. ITCHY! swollen ears! My biggest problem with itchiness was at night, when my cortisol levels would be at their lowest.

Mast Cells have Estrogen receptors. Before I figured the problem with my DNA and the Methylation cycle, I tried (a small amount) of progesterone cream, and it helped a lot. Here is an interesting discovery, I have had.....I cannot tolerate even 1mg of Clomid or Novla, EVEN NOW. I'll be itchy for a week. So, yes, estrogen can cause mast cells to degranulate.

NEXT, I have extremely low IGE ( 8 normal range 6-180), so mine is not a IGE mediated Mast Cell problem. This explains why Benadryl did nothing for me. I am not highly ALLERGIC to anything. We all are mildly sensitive to certain foods. Because I live on the very edge of a Mast cell reaction, anything that I have even a low IGE sensitivity to can make me itchy, if I eat enough of it. Now, if you actually have an IGE mediated allergy, such as dust, pollen, perfume, nuts, ie, then when added to low DAO that just makes this whole thing worst. Cinnamon is known to trigger mast cells.

My homocysteine is very low, because of my CBS homozygous mutation.

My T4 + Phytoestrogen joint pain was primarily in my left shoulder, I could not lift up my arm.

My diet is alcohol free, high soluble and insoluble fiber, low animal fat, lots of fresh fruit and vegetables, very low glycemic, small amounts of beans, nuts, cheese, Greek olive oil, Dutch gouda, ( I cheat, today I'm having pepperoni pizza for lunch, + DAOSIN)

If you have started reading about the Methylation Cycle, testing for DNA mutations that affects it, may be helpful. Warning, a little knowledge can be a dangerous thing. People frequently overdo supplements.

Have you tested you storage and active D3?

I have top of range SHBG. I blood test my hormones every 6 months. E2, SHBG, TT, FT, DHT all keep bouncing around, but SHBG is always highish. (I have blood tested, Danazol, Winstrol, Anavar, Proviron, Stinging Nettleroot Extract, to lower SHBG, NONE increased my FT to E2 ratio.)

First, you have to solve your Thyroid problems..... I have to avoid all goitrogenic foods, especially raw kale.

Do you know your E2 levels and range?????

 

[Cherrycoke]

FRESH fruit, FRESH vegetables, FRESH fish, bananas, Fresh tomatoes from my garden, are not histamine problems for me. Canned tomato sauce. Wine, leftover fish, DRIED fruit, salami / pepperoni, will trigger itchiness. I live on the edge of MAST CELL Activation. A slice of pepperoni pizza and a glass of wine and three hours later I know that I have more histamine than I can neutralize. ITCHY! swollen ears! My biggest problem with itchiness was at night, when my cortisol levels would be at their lowest.

Mast Cells have Estrogen receptors. Before I figured the problem with my DNA and the Methylation cycle, I tried (a small amount) of progesterone cream, and it helped a lot. Here is an interesting discovery, I have had.....I cannot tolerate even 1mg of Clomid or Novla, EVEN NOW. I'll be itchy for a week. So, yes, estrogen can cause mast cells to degranulate.

NEXT, I have extremely low IGE ( 8 normal range 6-180), so mine is not a IGE mediated Mast Cell problem. This explains why Benadryl did nothing for me. I am not highly ALLERGIC to anything. We all are mildly sensitive to certain foods. Because I live on the very edge of a Mast cell reaction, anything that I have even a low IGE sensitivity to can make me itchy, if I eat enough of it. Now, if you actually have an IGE mediated allergy, such as dust, pollen, perfume, nuts, ie, then when added to low DAO that just makes this whole thing worst. Cinnamon is known to trigger mast cells.

My homocysteine is very low, because of my CBS homozygous mutation.

My T4 + Phytoestrogen joint pain was primarily in my left shoulder, I could not lift up my arm.

My diet is alcohol free, high soluble and insoluble fiber, low animal fat, lots of fresh fruit and vegetables, very low glycemic, small amounts of beans, nuts, cheese, Greek olive oil, Dutch gouda, ( I cheat, today I'm having pepperoni pizza for lunch, + DAOSIN)

If you have started reading about the Methylation Cycle, testing for DNA mutations that affects it, may be helpful. Warning, a little knowledge can be a dangerous thing. People frequently overdo supplements.

Have you tested you storage and active D3?

I have top of range SHBG. I blood test my hormones every 6 months. E2, SHBG, TT, FT, DHT all keep bouncing around, but SHBG is always highish. (I have blood tested, Danazol, Winstrol, Anavar, Proviron, Stinging Nettleroot Extract, to lower SHBG, NONE increased my FT to E2 ratio.)

First, you have to solve your Thyroid problems..... I have to avoid all goitrogenic foods, especially raw kale.

Do you know your E2 levels and range?????

I cant test for DNA mutations via 23andme, since its not available in my country, only ancestry. Will see if I can fix it somehow through a friend in another country where it is available. But it feels kind of scary honestly, I just want to live without worrying about what is in my DNA, this extra information has both its pros and cons. But I feel something is off and that Im not reacting to medicines and treatments like "normal" people do, I almost always experience a lot of side effects from supplementing.
And my superhigh SHBG, for example, doctors ask me if I ever been on the pill and I have never, also if Im anorexic but I eat more than most people I know.

D3, you mean vitamin D as in 25-hydroxy vitamin D? Yes if so, have been low in the past but since supplementing and staying more in the sun, my latest test showed 75 nmol/L (ref.range 50-250 nmol/L) What test shows storage?

My latest estradiol test I took in april on day 21 in my cycle was 702 pmol/L (ref. range 300-1000) My progesterone was 42 nmol/L (ref.range 5.8-76)
I know the ratio was not optimal that cycle. Also my SHBG was 214 nmol/L. Do you know how to calculate free estradiol from SHBG, as they do with testosterone? Also, my albumin is in the lower range. What I do understand is that SHBG is protective, and if its protecting from high estrogen why is it that I cant get it down? It is as if the estrogen is stored inside of me and I cant excrete it, and it continues to rise. Maybe I dont have enough progesterone to counteract it? Could it be liver/inflammation/infection related?

I dont eat any goitrogens or soy. Had new thyroid bloodtest taken a couple of days ago, will have them this coming week.

 

[The Matrix]

Can not test vitamin D 1,25 where he is at due to transportation unless he is with in U.K. as they can ship it overnight. I have tested over 1000 people and 65% are coming back altered vitamin D 1,25 metabolism. The only companies I use in U.K. Is TDL for vitamin D 1,25. 30% of cases are coming out of U.K. now as there is a health epidemic there from Lyme and mold.
High shbg goes up in systemic inflammation namely liver or gi. I commonly see these number in mold exposures from homes or work places. With out proper history labs and other data it's just all speculation. Why I would suggest a Dutch hormone urine test 24 hour to be completed.

 

[Mr.TT]

I cant test for DNA mutations via 23andme, since its not available in my country, only ancestry. Will see if I can fix it somehow through a friend in another country where it is available. But it feels kind of scary honestly, I just want to live without worrying about what is in my DNA, this extra information has both its pros and cons. But I feel something is off and that Im not reacting to medicines and treatments like "normal" people do, I almost always experience a lot of side effects from supplementing.
And my superhigh SHBG, for example, doctors ask me if I ever been on the pill and I have never, also if Im anorexic but I eat more than most people I know.

D3, you mean vitamin D as in 25-hydroxy vitamin D? Yes if so, have been low in the past but since supplementing and staying more in the sun, my latest test showed 75 nmol/L (ref.range 50-250 nmol/L) What test shows storage?

My latest estradiol test I took in april on day 21 in my cycle was 702 pmol/L (ref. range 300-1000) My progesterone was 42 nmol/L (ref.range 5.8-76)
I know the ratio was not optimal that cycle. Also my SHBG was 214 nmol/L. Do you know how to calculate free estradiol from SHBG, as they do with testosterone? Also, my albumin is in the lower range. What I do understand is that SHBG is protective, and if its protecting from high estrogen why is it that I cant get it down? It is as if the estrogen is stored inside of me and I cant excrete it, and it continues to rise. Maybe I dont have enough progesterone to counteract it? Could it be liver/inflammation/infection related?

I dont eat any goitrogens or soy. Had new thyroid bloodtest taken a couple of days ago, will have them this coming week.

I may be Politically Incorrect here, but I also have Aspergers so. ( that is my excuse )

CherryCoke, are you Male or Female? Age? Height? Weight? on Pain Meds? Any pharm meds? Planning on children?

 

[Cherrycoke]

I may be Politically Incorrect here, but I also have Aspergers so. ( that is my excuse )

CherryCoke, are you Male or Female? Age? Height? Weight? on Pain Meds? Any pharm meds? Planning on children?

Go to page 1 and read my first post, haha.. Female, 34 years old, currently NO meds, thyroid before, 5'6, weight around 50 kg, yes to children.

 

[Mr.TT]

Go to page 1 and read my first post, haha.. Female, 34 years old, currently NO meds, thyroid before, 5'6, weight around 50 kg, yes to children.

I thought the HPTA was tricky, wow, distaff testosterone is involved.
Having little body fat and being active would increase SHBG. We evolved, so that we have less sex hormones if food was scarce.
If your only issue was greater muscle mass, I love (low dose) Anavar for women.

 

[The Matrix]

Sulfate strips can be used to indicate if you have a Transsulfuration pathway mutation, while you are waiting the two months it takes to get your DNA test results for a confirmation..

DNA tests are not going to determine b6 or b9 issues REALLY, did you forget what MTHFR is?

Not everyone is SIBO / Disbiosis / Leaky Gut /

Clinically the strips are not used any more as there are better ways to indicate CBS expression. That is a yasko approach that has been disproven as the body sulfur ebbs and flows over the course of the day.

Actually approximately 60- 70% of the the USA have some degree of NADFL

Just because you have a gene does it means its expressing. This is the biggest misconception being promoted in health field. Its very dangerous approach which has resulted in people almost committing suicides and heart attacks etc by giving 5 methyl folate treating the MTHFR.
I rarely focus on MTHFR as its just a small blip on a huge genetic maps.
Only time I focus on it is when there is history of blood clotting issue or miscarriages, strokes or CVD.
One needs to look at the entire genetics, biochemistry, lifestyle, environment etc.
I rarely look at the genetics as it is not needed if you address the underlying pathology which is altering the gene expression.

MTHFR works in synergy with other genes not just as a stand alone.

I work with well respected names in methylation and epigenetics helping to influence the mind set of people like DR Ben lynch and many others in the field to look at snps differently over the years. If not Doctors would still be chasing and treating the snps doing more harm then good. .

I am just stating facts easily verified.

I may not have a degree, or letters behind my name, people and doctors could care less.