I could only do 25-50 mcg, and that is considered a starting dose. But whenever I tried to up from 50 mcg, the toxic feeling got worse.
Do you know why T4 and not T3 I guess lowers DAO & MAO levels?
I would love to hear what solution has worked for you? And have you got back the muscles you lost while on T3? My strength is still very decreased and I have a lot of vascularity on my arms Unfortunately.
T4 lowers the intestine's output of systemic DAO, for EVERYONE! What causes problems for a few of us is we have GENETICALLY lower DAO levels. Most people have so much extra DAO that when T4 lowers their DAO, they still have more than enough.
MY STORY, MY STORY.......
Even below 100mcg T4 caused me joint pain, if I ate beans or soy. (T4 + Phytoestrogen = joint inflammation)
At 100mcg of T4 , I still had a TSH above 4, and I developed multi-nodule thyroid goiter.
So, ENDO upped my T4 to 125mcg. All hell broke loose. My ears swelled shut, roof of my mouth itched like hell, hives on my forearms, vasodilation rashes on my cheeks and throat. I got depressed, but I think it was because ENDO, ENT, PCP, and ALERGIST were worthless.
I noted that foods high in Phytoestrogen and Histamine increased my itching. BENADRYL did nothing to help, but Klonopin, Zyrtec, vitamin C HELPED SOME. By now I felt I was dealing with a MASTCELL problem. The question was how would T4 trigger my mastcells.
I had to take Chewable vitamin C every 3 hours, so I looked into making LIPISOMAL vitamin C. You use lecithin, to make it, and lecithin contains
CHOLINE. I was unfamiliar with choline and researched it. My diet was not high in choline, so I picked up a choline supplement. Took it, and in three hours I felt better than I had for years. So, what the hell did choline do?
That sent me to the Phoenix Rising Web Site, 23ANDME DNA tests, SULFATE urine test strips, and learning about the Methylation Cycle.
Here is my untrained opinion about what caused and fixed my many many year problem with T4.
T4 lowered my DAO level to the point that I had inadequate DAO to keep up with my circulating histamine.
My cells were forced to utilize HNMT to methylate histamine. Therefor using up SAM and creating lots of homocysteine.
I have double mutations on my Transsulfuration pathway gene. It eats up homocycteine before the Methylation Cycle can regenerate it back into SAM.
I became UNDERMETHYLATED, and unable to neutralize histamine and calm my mastcells.
The reason Choline/TMG helped is, they drive a Methylation Cycle shortcut that converted homocysteine back into SAM before the Transsulfuration pathway enzyme could destroy it, thus increasing my SAM.
Before you can solve a problem, you must understand it.
My problem with T4 was controlled by;
Advoiding high phytoestrogen and histamine foods.
Taking NDT sublingually (natural desiccated thyroid, ERFA, NatureThroid, etc.) still keeping my supplemented T4 below 100mcg. My TSH is now below 1 and my thyroid nodules dissolved.
Taking 1 gram of Liposomal Vitamin C (ascorbic acid)
Taking 100mg of choline
Taking 500mcg sublingual MB12 (methylcobalamin)
Taking 100mcg molybdenum ( an upregulated Transsulfuration pathway uses lots of molybdenum)
Taking as much DAOSIN as needed. (supplementing DAO)
My DNA tests indicate that I do not have vitamin B6 or B9 issues.