My estrogens are pretty good. It's my high SHBG that is messing me up - was 55 - now 44 with the addition of Danazol - but as you know 44 is still high. Per Dr. S's chart
my total test would have to be close to 1000 to get me to a Free T of around 200 which is where he (and I) want to be. Right now it's around 120. I probably can't do much more HCG (600iu EOD) because my estradiol nearly doubled (15 to 26) when I went from 500iu to 600iu and my total T only moved up slightly from 600 to 700.
If I could get my SHBG down to 25 or 30 my Free T would be perfect. What else can reduce SHBG?? Any "natural" supps??
I do not see much reason of doing anything that I would not do on long term basis.
Hoping to put down pressure on SHBG
I would try to stay closer to lower range on
FreeE2(0.45 - 0.6)
while doing this test at Quest
Estradiol, Free, LC/MS/MS (36169X)
380iu HCG EOD
You may get good mileage doing Genova
NutrEval
------------------------------------------------
Invalid Link Removed
Dr Marianco
High SHBG is associated with high estrogen states (e.g. with obesity) or low DHEA (e.g. with adrenal fatigue).
========================
Supraphysiologic doses of testosterone or other androgens can drive SHBG lower.
++++++++++++++++++++++++++++++++++++++++++++
What kind side effects have Danazol?
Invalid Link Removed
The following reactions have been reported, a causal relationship to the administration of Danazol has neither been confirmed nor refuted: allergic: urticaria, pruritus and rarely, nasal congestion; CNS effects: headache, nervousness and emotional lability, dizziness and fainting, depression, fatigue, sleep disorders, tremor, paresthesias, weakness, visual disturbances, and rarely, benign intracranial hypertension, anxiety, changes in appetite, chills, and rarely convulsions, Guillain-Barre syndrome; gastrointestinal: gastroenteritis, nausea, vomiting, constipation, and rarely, pancreatitis; musculoskeletal: muscle cramps or spasms, or pains, joint pain, joint lockup, joint swelling, pain in back, neck, or extremities, and rarely, carpal tunnel syndrome which may be secondary to fluid retention; genitourinary: hematuria, prolonged posttherapy amenorrhea; hematologic: an increase in red cell and platelet count. Reversible erythrocytosis, leukocytosis or polycythemia may be provoked. Eosinophilia, leukopenia and thrombocytopenia have also been noted. Skin: rashes (maculopapular, vesicular, papular, purpuric, petechial), and rarely, sun sensitivity, Stevens-Johnson syndrome; other: increased insulin requirements in diabetic patients, change in libido, elevation in blood pressure, and rarely, cataracts, bleeding gums, fever, pelvic pain, nipple discharge. Malignant liver tumors have been reported in rare instances, after long-term use.