Have u used "DNP"
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theamazing3000
Member
only 7-10 pounds on 25 DAYS of DNP. I have not used dnp yet, but it seems to me as though you should have lost more. I mean i have lost a lot more with just triac.
XxCrisisxX
Member
Here an old post about DNP.
DNP stands for 2,4-dinitrophenol. This is a chemical that was once used in the early 20th century to ignite dynamite and cast a yellow dye on wood and other handcrafts. A few years later demographical statistics showed that employees who worked with DNP everyday tended to lose weight, often rapidly. One fall out from this was a study conducted by Stanford University in 1920 showing that the ingestion of DNP does in fact cause weight loss. This prompted physicians to prescribe DNP to obese patients of that era. DNP was on the market for 2 decades as a weight loss drug and was eventually taken off the market and banned for human consumption by the FDA because there was a report of cataract formation among female users of this drug which turned out to be false. This chemical is still deemed too dangerous by the FDA to allow it to come back to the pharmaceutical marketplace. Over the decades of research on DNP, scientists have never shown it to have the ability to cause cancer or any other mutations despite the fact that it’s a phenol and that most phenolic compounds are carcinogenic. DNP is now only used as a research chemical and as a pesticide in a few states that still approve of its use. It is not illegal to own DNP, but it is illegal to market it for personal consumption.
Ever notice that everyone says that its extremely dangerous but never really back it up with anything? I do. So heres some actual studies about DNP.
DNP is Ames negative, and does not promote tumors. See for yourself at Invalid Link Removed
Invalid Link Removed reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.
Invalid Link Removed reports on health risks from external exposure. In other words, don’t get it in your eyes, or on your skin if you’re allergic. Pretty elementary stuff.
Invalid Link Removed This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.
Invalid Link Removed A PDF file about an antidote to DNP.
Invalid Link Removed finds that DNP did not activate liver enzymes (MAT) associated with liver damage
"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.
"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know—it’s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst result being softened stools and gas).
"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as…2,4-dinitrophenol (DNP)."
"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out—DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure…"
"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.
Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it’s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer…fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP is being synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.
"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it’s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity…"
"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP’s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.
"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.
"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates—or disrupts—cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.
"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT(good ol’ DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect…"
"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."
"Autocatabolism of surface macromolecules shed by human melanoma cells."
Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps
melanoma cells die (autocatabolize) while other cells are unaffected.
Invalid Link Removed - tons of research, including medical studies. Excerpts:
DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation © 1996 Robert Ames)
Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."
"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."
"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."
"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."
"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."
"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."
Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
So, as you can see, when taken in moderate doseages (lets say 200mgs per day), its quite safe. The lethal dose is roughly 20-30mg/kg.
DNP stands for 2,4-dinitrophenol. This is a chemical that was once used in the early 20th century to ignite dynamite and cast a yellow dye on wood and other handcrafts. A few years later demographical statistics showed that employees who worked with DNP everyday tended to lose weight, often rapidly. One fall out from this was a study conducted by Stanford University in 1920 showing that the ingestion of DNP does in fact cause weight loss. This prompted physicians to prescribe DNP to obese patients of that era. DNP was on the market for 2 decades as a weight loss drug and was eventually taken off the market and banned for human consumption by the FDA because there was a report of cataract formation among female users of this drug which turned out to be false. This chemical is still deemed too dangerous by the FDA to allow it to come back to the pharmaceutical marketplace. Over the decades of research on DNP, scientists have never shown it to have the ability to cause cancer or any other mutations despite the fact that it’s a phenol and that most phenolic compounds are carcinogenic. DNP is now only used as a research chemical and as a pesticide in a few states that still approve of its use. It is not illegal to own DNP, but it is illegal to market it for personal consumption.
Ever notice that everyone says that its extremely dangerous but never really back it up with anything? I do. So heres some actual studies about DNP.
DNP is Ames negative, and does not promote tumors. See for yourself at Invalid Link Removed
Invalid Link Removed reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.
Invalid Link Removed reports on health risks from external exposure. In other words, don’t get it in your eyes, or on your skin if you’re allergic. Pretty elementary stuff.
Invalid Link Removed This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.
Invalid Link Removed A PDF file about an antidote to DNP.
Invalid Link Removed finds that DNP did not activate liver enzymes (MAT) associated with liver damage
"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.
"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know—it’s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst result being softened stools and gas).
"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as…2,4-dinitrophenol (DNP)."
"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out—DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure…"
"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.
Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it’s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer…fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP is being synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.
"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it’s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity…"
"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP’s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.
"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.
"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates—or disrupts—cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.
"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT(good ol’ DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect…"
"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."
"Autocatabolism of surface macromolecules shed by human melanoma cells."
Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps
melanoma cells die (autocatabolize) while other cells are unaffected.
Invalid Link Removed - tons of research, including medical studies. Excerpts:
DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation © 1996 Robert Ames)
Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."
"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."
"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."
"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."
"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."
"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."
Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
So, as you can see, when taken in moderate doseages (lets say 200mgs per day), its quite safe. The lethal dose is roughly 20-30mg/kg.
silverknight
New member
I prefer clen, DNP does work better but it makes your life hell. I would rather use clen and work a little hard and feel heathy then lead a sweaty no productive life,
b-boy
Member
if your not a top competitive bodybuilder, i see no reason to use dnp, the risk are just not worth the weight loss, I used dnp to get ready for a national qualifier this past year and yea, i will admit i lost a shitload of fat, but damn you feel like death, and i feel it is only slightly better than clen + t3, wich works great without the chance of death, but t3 must also be respected.
maetenloch
New member
Here's a good collection of info on DNP:
Invalid Link Removed
and here's Dr. Bachynski's original patent:
Invalid Link Removed
IMO low dosages (200mg) of DNP for longer periods is the way to go. You'll still lose weight
but it'll be over a longer period and you'll avoid most of the side effects. At 200mg ED, I find
that it has little effect on my workouts and cardio other than additional sweating. Doing 600mg
or above a day is just asking to be miserable and non-functional. Plus if you think about it, losing
a pound of fat a day is going to be unhealthy no matter how you do it.
Invalid Link Removed
and here's Dr. Bachynski's original patent:
Invalid Link Removed
IMO low dosages (200mg) of DNP for longer periods is the way to go. You'll still lose weight
but it'll be over a longer period and you'll avoid most of the side effects. At 200mg ED, I find
that it has little effect on my workouts and cardio other than additional sweating. Doing 600mg
or above a day is just asking to be miserable and non-functional. Plus if you think about it, losing
a pound of fat a day is going to be unhealthy no matter how you do it.
Strateg0s
Registered User
That was my thought on the matter. If you look at the doctor administered use of DNP it was an average of ~175mg for many months. I have not seen a well reasoned argument to back the opposing position. Assuming you are taking the right supplements, how is taking ~600mg/day for 2-3 weeks a better idea than taking say 150mg for say 4x that amount of time: same amount of DNP consumed, more supplements to DNP ratio, and your metabolism would be raised for a lower degree for a longer period of time. The inclusion of T3 in the supplement regime would be necessary for longer stints. If DNP is not toxic (and the science indicates that it is not - being cooked is different from the substance being toxic) - if DNP is not toxic, then lower doses for a longer duration seems like the way to go. People reading this board should not be so enormous that they would actually have to run it that long.maetenloch said:
MTNMEDIC
Guest
Death is one of the side effects ? Bummer......
acecombact1
Member
artica said:
yes it can, there is studies where they used T3 for long time and throid was shut down permanently.
that dosnt mean it cant be used safly for short periods of time.
Strateg0s
Registered User
DNP use: 100mg/day elevates your metabolic rate by ~12%, 200mg=~20%, 300mg=~30%. Fat loss at those doses with no change in diet varies from ~400g to ~600g/wk. So get your damned diet in check first of all, then if you "must" use DNP, use a low dose, and take a lot of anti-oxidants, a measure of the supplements list discussed in many a DNP protocol, frequently administer fructose to keep liver glycogen levels above critical, drink a lot of water, don't do stupid things to greatly overheat yourself. There does not seem any good reason to use DNP at over 250mg/d, since the risk vs. returns plummets. If you were to use it for longer than three weeks, it would be a good idea to supplement with T3 50-100mcg. Having a modicum of patience to increasing your BMR by "just" 20% will strip off your unwanted fat without tempting all sorts of dangerous side-effects. That said, almost any degree of weightloss is possible with the self-discipline necessary to act on knowledge of correct training and nutrition. If you "have to" resort to DNP, I really don't understand why you would want to use it stupidly, for the sake of an extra pound a week of fatloss.
It is worth noting that DNP can cause a certain amount of water retention, which will be lost after ceasing to administer the drug. Just one more reason for those people who use this to be patient, to use low doses rather than to stupidly blast through a few brimstone weeks of thermogenesis.
Source for the numbers: The International Association for the Study of Obesity. Obesity Reviews 2, (November 2001) 255–265 "Mitochondrial uncoupling as a target for drug development for the treatment of obesity"
It is worth noting that DNP can cause a certain amount of water retention, which will be lost after ceasing to administer the drug. Just one more reason for those people who use this to be patient, to use low doses rather than to stupidly blast through a few brimstone weeks of thermogenesis.
Source for the numbers: The International Association for the Study of Obesity. Obesity Reviews 2, (November 2001) 255–265 "Mitochondrial uncoupling as a target for drug development for the treatment of obesity"
artica
New member
I have never seen any reports showing this, but if you have then you have.acecombact1 said:
On the subject of DNP, Ive heard from experienced users that the leaner you are the less of a result your'll receive from it, basically
dnp sounds to be a drug to be used by those over 20% or so.
exnihilo
Well-known member
Seriously, anyone considering DNP should try running tren in the neighborhood of 500-700mg/week. I got wonderful fat loss with 500mg/week of trenE, without feeling like death. If you try it and find you're not one of those people that responds well to tren, then perhaps low dose, moderate use of DNP may work for you. But many people posting here will find that they get far better results with the tren...
JBlaze
Board Sponsor
Edge said:
The benadryl serves two purposes.
1) It contains the same ingredients as sleeping pills, which def helps one to sleep when sweating and such during the night.
2) It is not extremely uncommon for a person to develop hives/itches while on DNP. It's just much easier to spend $5-6 for a 10 day supply, and avoid any potential problems before they arise.
Strateg0s
Registered User
Do you have a certain protocol? I have read the standard advice, glycerin for hydration, plus as many anti-oxidants as you can stomach.DR.D said:
Also, what do you think of the idea of running it longer at lower doses, as compared to shorter bursts at high doses? It seems obvious to me that the former would be preferable, slow and steady, but maybe I am missing something - important.
artica
New member
I remember reading, I believe over at meso that longer low dose cycles are preferred. More tolerable, less dangerous, and further use equaling more loss.Strateg0s said:
Protocols for antioxidant use would be something like:
Vitamin E at 800iu (2 seperate doses)
Grape seed extract
Milk Thistle - 600mg of silymarin extract
Vitamin C - 3g minimum
B-complex - 100% 2 doses
alpha lipoic acid - I'd go up to 1g of this a day in seperate doses
Inositol - 1g 3x a day
syntrax Radox - is a great antioxidant combo as well
DR.D
Well-known member
This best summarizes the approach I used:
Invalid Link Removed
200mg/d for 10 days, that's all I could handle. It works wonders, but it's like M1T. You just hate the way you feel on it. I don't know that I'll ever do it again, unless we go into another ice age and I have to stay warm somehow. I hate clen after a few days for that matter, I'd rather crash diet w/ 100g protein/d, a good anabolic and yohimbe.
Invalid Link Removed
200mg/d for 10 days, that's all I could handle. It works wonders, but it's like M1T. You just hate the way you feel on it. I don't know that I'll ever do it again, unless we go into another ice age and I have to stay warm somehow. I hate clen after a few days for that matter, I'd rather crash diet w/ 100g protein/d, a good anabolic and yohimbe.
Chippewa
Member
I haven't really changed my mind about anything in the article, and I still love the stuff (on it now, in fact!)Strateg0s said:
Reagent grade just means it meets a standard for purity. Since DNP tends to be pretty pure anyway (unless you're using a chemical suuplier that just sells industrial grade junk anyway), it's pretty much all good. I use stuff that's actually made in a lab, though, just because I like it better. It's a crystalline form, which some people swear works faster, but I've really noticed little difference. I just like the idea that what I use was made in a lab, not in a chemical warehouse.
As for the stories about DNP that inevitably surface ("I know a guy who went to the ER on the stuff!"), those seem to be an archetypal tale with about as much reliability as "My great-grandmother was a Cherokee princess (...but the records were lost/courthouse burned/we can't prove it)." In other words, it's a claim we all hear over and over again, but usually emerges with more drama than proof.
Chippewa
Member
Tren works better? Tren lifts your metabolism more than 60% per day? I'm not downing tren at all, but I don't think it's has nearly the same inferno effect...not to mention that you don't have to pin DNP--let alone ED or EOD.
I think DNP would be a good "weekend blitz" on a bulking cycle to cut back extra fat gain without seriously impairing gains from extended cutting.
I think DNP would be a good "weekend blitz" on a bulking cycle to cut back extra fat gain without seriously impairing gains from extended cutting.
exnihilo
Well-known member
Chippewa said:
With weak ass underdosed tren, I still leaned out very rapidly, felt fine and maintained strength. With properly dosed tren and higher overall dosages, I can imagine gaining strength while leaning out even more... As opposed to feeling sick and weak, and playing around with a substance which is quite frankly very scary.
Scottyo
Well-known member
I too am a big fan of DNP. Although the longer cycle lower dose sounds good (and is in fact probably the safer/better), I am really hesistant to tell people to do 'longer' cycles. Some people interpret longer as in multiple weeks, and IMO that is just too long to handle the discomfort, necessitates the use of t3, and has a worse recovery/rebound period. I personally do not like going longer than a week, and then taking time off and doing another week cycle. I know of a few people who like weekend blitz cycles...taking advantage of the long half life and loading up, then letting it clear. Recently I had a friend who went with an unknown (to me at least) supplier that A) charged a pretty penny and B) supplied some abnormal stuff. The individual had some significant psychological side effects, with minimal fat loss. I really can't explain the cause, but if anyone else has heard anything similar I would be interested to know. As always, know what your getting your hands on -and even more so with something with such a low LD50.
DR.D
Well-known member
Chippewa said:
It's an oxidant, it can be readily reduced w/ sodium metabisulfite for example. It has 2 nitro groups, so don't believe that the 1-OH is going to save it. Anyway, I've used the w/e blitz successfully w/ a Friday noon, night and Saturday morrning dose schedule. But it sucks feeling like crap on the w/e.
Boss_K
Active member
I thought this was funny because the study on meso had links that didnt even work and lots of false info. Heres the offical stance on dnp and cancer:
How likely are dinitrophenols to cause cancer? The Department of Health and Human Services (DHHS), the International Agency for Research on Cancer (IARC), and the EPA have not classified dinitrophenols for carcinogenicity.
There are no studies available in people or animals on the carcinogenic effects of dinitrophenols.
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You can believe and do what you want, but when I told my buddy whos in med school about dnp he flipped his ****. He actually had just been studying it and NEVER would have thought people would actually be introducing this to their body as a supplement.
How likely are dinitrophenols to cause cancer? The Department of Health and Human Services (DHHS), the International Agency for Research on Cancer (IARC), and the EPA have not classified dinitrophenols for carcinogenicity.
There are no studies available in people or animals on the carcinogenic effects of dinitrophenols.
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You can believe and do what you want, but when I told my buddy whos in med school about dnp he flipped his ****. He actually had just been studying it and NEVER would have thought people would actually be introducing this to their body as a supplement.
the anapolack
New member
dnp worked fine for me....ran 3 cycles
anabolic rebound seems to be due to muscles being filled back up due to being "flat" because no glycogen storage in tissue
anabolic rebound seems to be due to muscles being filled back up due to being "flat" because no glycogen storage in tissue
Loki
Supplement Jester
There's actually a change in body fluid retention, extracellular --) intracellular, once you go off of DNP. That crazy-volumization of your skeletal muscle cells is probably able to prompt some hypertrophy in itself. Just strength train and carb up (and throw in some osmolytes/phosphate-donors), and voila, "anabolic rebound".
"The Hell-Fire" truly is a fascinating (and frightening) substance.
"The Hell-Fire" truly is a fascinating (and frightening) substance.
JBlaze
Board Sponsor
i got a random one here:
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i know theres 2-3 more that are around, but i dont feel like looking for them. This pic is about a year old i think, pre my 16 week test/EQ/GH/IGF run, and also prior to DNP. I look "Slightly" different now. I'll really do need to post new pics...
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i know theres 2-3 more that are around, but i dont feel like looking for them. This pic is about a year old i think, pre my 16 week test/EQ/GH/IGF run, and also prior to DNP. I look "Slightly" different now. I'll really do need to post new pics...
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