The type of GDA used should be decided by your goals. Is fat loss and insulin sensitivity your goal? Then go with an AMPK heavy GDA, such as dihydroberberine/berberine. DHB/ BB is the single most effective AMPK-based GDA on the market, period. Of course, DBH/BB products are often stacked with other ingredients. Some of these products primarily and potently target a singular goal, such as fat loss, so they will typically contain other fat loss-based ingredients. Other products will contain a miss-mash of ingredients that provide all sorts of different effects, but the strength of each effect will be more moderate in nature, thereby making the product a "jack of all trades" rather than an expert in a single area. Both kinds of products can be great, depending on what you're looking for.
If you're looking for more of a growth oriented GDA, then you don't want to go super heavy on the AMPK component. Some AMPK activation is OK and even good for growth, but excessive activation is not. If you prioritize growth, you want products which contain more insulinotropic ingredients.
Remember, both AMPK-based ingredients and insulinotropic ingredients still provide "glucose disposal" effects. The difference is in HOW they do so. This makes some better suited for growth, and others better suited for fat loss.
Furthermore, GDAs as a class rarely work through just a single pathway. For example, one ingredient may be primarily insulinotropic, but that doesn't mean it doesn't activate AMPK. It may indeed activate AMPK, but just not to the same degree as its primary pathway (ex. insulin release). Likewise, just because an ingredient primarily targets AMPK, it does not mean it possesses zero insulinotropic/insulin mimetic effects. When selecting a GDA ingredient(s), we should choose those which best target the pathways that help us accomplish our goals.
There is no need to cycle GDAs, but you can if you want to.