Gaba
- Thread starter rhoadx
- Start date
Nickespo89
Member
I definitely notice a difference when I take it. Have you ever used phenibut?
HIT4ME
Well-known member
Yes, there is debate over whether or not GABA crosses the BBB - but it appears that large doses (whatever dose that is) can cause GABA to cross the BBB. It also seems to me that, from personal experience, it works for improving sleep. From researching online, it appears that many others agree that they see improved sleep with it.
So, I guess, a few things could be going on.
1. We could be wrong - it does somehow cross the BBB.
2. Maybe taking it exogenously is "sparing" in that it can still be used throughout the body, which means you can use more of your endogenous GABA in your brain.
3. Maybe just the fact that it relaxes your body, even though it isn't acting directly on your brain, sends the signal to your brain that you are relaxing/sleeping. Your body does interact with your brain of course, and if GABA can shut down nerve impulses in your body, your brain should follow.
4. Maybe a combination of the above, all of the above or none of the above.
So, I guess, a few things could be going on.
1. We could be wrong - it does somehow cross the BBB.
2. Maybe taking it exogenously is "sparing" in that it can still be used throughout the body, which means you can use more of your endogenous GABA in your brain.
3. Maybe just the fact that it relaxes your body, even though it isn't acting directly on your brain, sends the signal to your brain that you are relaxing/sleeping. Your body does interact with your brain of course, and if GABA can shut down nerve impulses in your body, your brain should follow.
4. Maybe a combination of the above, all of the above or none of the above.
HIT4ME
Well-known member
Phenibut is WAY stronger. I'm using APS Revivarant G right now with Phenibut, GABA and GABOD - I have found that 1/4 - 1/3 scoop is great for some really good sleep.
kboxer7
Well-known member
Agree 100% on the phenibut. Just watch out for tolerance. Also, 1g and above is said to be hard on the kidneys.
smith_69
Well-known member
and make SURE YOU CYCLE on and off with phen- 2-3 days on 4 days off. tolerance as KB said will build up and this can become additive
smith_69
Well-known member
pretty much on point here hit-
also, some studies show that that manganese can also facilitate GABA supplements crossing the BBB. What is also interesting is the activation of vitamin B6 and how it is a key to synthesize GABA.
The brain removes excessive amounts of it at roughly 16 times the uptake rate. So regardless of whether or not it crosses the BBB, the brain is breaking down GABA too quickly for researchers to observe any significant difference in the levels.
Most of the research on GABA supplements and the BBB is conflicting. GABA supplements are most likely broken down by the brain due to excessive amounts and, therefore, may not directly influence neural activity in the central nervous system.
dave39
Active member
Used it and noticed nothing from it. It's in the ever growing bucket of "useless supps" in my basement now.
machinehead
Well-known member
My heart rate doubles from resting when I dose above a gram at a time. No other effects for me but I got the shortness of breath in the beginning.
