It should still be less harmful then the majority of low dosed methyls at that high dosage range. The majority of users at those doses have not experienced any negative sides, besides lethargy, dehydration, and joint dryness. There have been some exceptions though, such as reaperx's two week log that resulted in him having nosebleeds. I don't know what to say about that one, b/c I don't know anything about his cycle, since he deleted everything in his mini-log. There really isn't any legitimate bloodwork results available to guage any negative effects it may have on users. I am sorry I couldn't be of more help. All I have is heresay.