I have been taking DIM so thats what it may be the estrogen getting burned off Hopefully. I took a .5 mg of armidex and my anxiety and brain fog went away but still have this horrible joint pain, constipation ..I"m not a big fan of dim and waiting for iodoral to get here beacuse you know what it is and know it only contains just iodine and nothing else affecting absorpton. I think iodoral will just flush out the 16 hyroxy vs having to go through all the metabolitic steps. I know I have had bad insomnia and also poor digestion and appeite past few weeks. I am wondering if the pregenlone is causing rise of progesterone and estrone metabolism. Drs got the test but still have not gottn results GRRR. Going to store to get P5P , gaba. P5P i was taking only was 1/2 dosages and not taking full dosage for a while 150-200 mgs a day