dsade
NutraPlanet Fanatic
This one was started a year and a half ago, but stayed in development until it was perfected. This is incredibly complex, both from a mechanism and a production standpoint. Hoping to have this ready for New Year, but Defuse and Gut Health restock sales will determine for sure.
Exemplar(tm)
Exemplar(tm) is a cutting edge nutritional supplement designed to primarily enhance the GLP-1 pathway, to sensitize thebody to insulin and suppress appetite to assist in lifestyle changes that will help the body burn fat and return to a reasonable baseline. Exemplar(tm) contains a potent GLP-1 agonist (which acts like GLP-1), an enzyme inhibitor to prolong the action, fat burning compounds, GLP-1 receptor sensitizers, and GLP-1 secretagogues (compounds which trigger the body to release GLP-1). It also seems to blunt the brain’s reward centers that are normally activated by yummy snacky carb heavy foods and reduce the cravings for junk, allowing you to choose your diet wisely rather than being driven by urges (sort of like going grocery shopping when you are starving...bad idea.)
GLP-1
GLP-1 is being covered extensively, lately, with the popularity of products such as Ozempic and Mounjaro. It is being touted as a miracle. They are mostly known for abolishing appetite for extended periods of time, resulting in rapid weight (not necessarily fat) loss, as well as extremely unpleasant side effects.
Far from being a miracle, the synthetic GLP-1 products are a temporary fix at best, with the bounce back being severe.
GLP-1 agonists imitate a hormone called GLP-1 (Glucagon-Like Peptide 1). Activating the GLP-1 receptor (usually by means of eating) triggers an insulin release from the pancreas as well as an immediate blunting of appetite (you know, since you just ate and all). The insulin “unlocks” the cells of the body allowing for those recently ingested nutrients to enter the cells to be burned (in the case of sugar), stored (as either glycogen or fat), or used for repair or building new tissue (in the case of protein.)
Normally this is essential for life to continue, as a bunch of sugars, etc rolling around in the circulation is not only useless for body functions but damaging to tissues.
Now, while blood sugar levels are high, and while insulin (released by the pancreas in response to those sugar levels) is circulating, the body will not burn fat. Why is that? Well, because the body burns fat in response to low fuel levels – notably not enough glucose (sugar) to meet the required demands such as exercise, hunting, fleeing from predators, etc.
Glucagon (related to GLP-1) is a dominant hormone that suppresses appetite. So you have something the clears blood sugar, which enables fat burning, and inhibits appetite. Short term it is quite effective, but it is simply not sustainable long term. Or is it?
EDIT: Quick aside. Every hormone in our body, once secreted, must also be broken down and eliminated by enzymes. In the case of GLP-1, the enzyme is called DPP4 (Dipeptidyl peptidase 4)
Insulin/Insulin Resistance and Obesity
As mentioned above, Insulin is released by the pancreas when elevations in blood sugar, and some amino acids (protein) are detected. This immediately shuts down fat burning, and reverses the process to begin storing nutrients in any available tissue, including fat cells.
The curse of modern excess, with high calorie foods readily available, is that people tend to “snack” constantly. We wind up pushing a steady stream of mostly carbohydrates into our bodies, which triggers a near constant insulin elevation. Now, much like lightly brushing your skin in the same spot for a long time, what initially feels good eventually deadens to that stimulation until you don’t feel much of anything. Insulin and cells are the same way. With insulin constantly “knocking” on those cells to open up and take in more nutrients, eventually the cells start ignoring that knocking, instead just turning up the TV volume and hoping that pesky insulin just goes away. Now without anywhere to store those nutrients (usually carbs/sugars) they just circulate around causing damage to nerves, blood vessels, and pretty much anything else they touch. The consequences can be miserable, crippling, and even deadly, and most certainly unattractive.
Adiponectin/Leptin/Adropin
Adiponectin
Adiponectin was named, a bit incorrectly, because it was thought to be secreted only by White Adipose (that ugly stubborn fat) as a balance for obesity. We now know that Adiponectin is also secreted by metabolically active tissues such as Skeletal muscle and the liver. It acts as an insulin sensitizer (which combats insulin resistance covered above) and acts to ramp up metabolism when adiposity (body fat %) becomes excessive. By increasing fatty acid oxidation, it works to keep our bodies within a reasonable body fat range. Usually.
Leptin
The complexity of Leptin could take up dozens of pages and still not do it justice. Also secreted primarily by fat cells, Leptin acts both of peripheral tissues, but more importantly acts on the brain to control metabolism and appetite. Say you are hungry, so you grab a pizza. You eat a slice, maybe 2, and the Leptin signal to your brains says “Ok, that’s all the fuel you need” and shuts off your hunger signal. But let’s just say that this pizza is really, REALLY good...so you ignore it and keep eating. Eventually (not that first time, but if you overeat chronically) your brain will also start to ignore the Leptin “I’m not hungry” signal (like Insulin resistance, this is called Leptin Resistance) and instead your brain will start to signal that you are hungry. All…..The….Time.
Adropin
Adropin is a new player entering the game, or at least our knowledge of it. Discovered only in 2008, Adropin is turning out to be one of the key players (with the previous 2) in balancing energy storage and usage. Adropin is secreted primarily by the liver and the brain, with lower levels secreted by the heart and the GI tract. Now, excess adiposity (obesity) massively lowers the body’s secretion of Adropin. Now, Adropin is being studied more and more, with these studies indicating that it is another key controller of metabolism and energy balance. As another piece in the metabolic puzzle, you can start to see how Insulin resistance, Adiponectin, Leptin/Leptin resistance, and obesity controlled suppression of Adropin lead to the mess that the Modern Western World (and increasingly other cultures) are experiencing with regards to health problems, lowered life span, a ridiculous number of prescriptions that don’t solve any problems, obesity, and overall lower quality of life. Of Note: Adropin seems to be a highly dynamic hormone. Though initially, rises in Adropin cause a reduction of body fat, if accompanied by overfeeding high fat or high sugar foods, the rise can exacerbate fat gain. Lesson – be mindful of your diet.
Lipolysis
Before we get too far into this, let’s give you a quick lesson on Lipolysis. Despite some misinformation out there, lipolysis is not actually a process of burning fat. Lipolysis is taking the fat that is stored in your fat cells and “squeezing” it out, like juice from an orange. These freed fatty acids then take a few laps around the circulation, checking out the scenery and looking for somewhere to actually be burned, then if there is not enough demand they just boogie right back into that fat cell and you’ve accomplished nothing. And again, if the hormones are knocking but the cells won’t let them in, then that fat you want so badly to burn simply...won’t be.
Lipolysis is triggered by a reasonably simple process. Catecholamines (dopamine, adrenaline, etc) combine with something called Hormone Senative Lipase and cAMP (and a few others...so simple is relative) to signal to those fat cells that we need fuel STAT (usually in response to fight or flight).
Once released from the fat cells, as mention, it needs a destination. Moving on…
cAMP
This is a bit tricky. CAMP, or cyclic Adenosine Monophosphate, communicates to the rest of your body your “energy state”. When your fuel stores are full of a form called Adenosine TriPhosphate, then your body prefers to run on that. Ripping a phosphate group off (sort of like a road flare being scraped on the pavement) releases a tremendous amount of energy, to allow your muscles to move, etc. When the first phosphate is taken, you are left with Adenosine DiPhosphate (di meaning two). There is still energy potential there, though less. When that second phosphate is removed, you are left with Adenosine MonoPhosphate (mono meaning one) and a cascade occurs to signal your body that it needs to replenish. Body Fat is one of the first places it goes to replenish, which is what we are shooting for.
As mentioned in the Lipolysis section, cAMP is required for lipolysis.
Side Note: Adenosine, without any phosphates, causes your body to get very tired (which makes sense since energy levels would be low). Caffeine blocks Adenosine from docking with its receptor, which is how it keeps you awake.
Exemplar(tm)
Exemplar(tm) is a cutting edge nutritional supplement designed to primarily enhance the GLP-1 pathway, to sensitize thebody to insulin and suppress appetite to assist in lifestyle changes that will help the body burn fat and return to a reasonable baseline. Exemplar(tm) contains a potent GLP-1 agonist (which acts like GLP-1), an enzyme inhibitor to prolong the action, fat burning compounds, GLP-1 receptor sensitizers, and GLP-1 secretagogues (compounds which trigger the body to release GLP-1). It also seems to blunt the brain’s reward centers that are normally activated by yummy snacky carb heavy foods and reduce the cravings for junk, allowing you to choose your diet wisely rather than being driven by urges (sort of like going grocery shopping when you are starving...bad idea.)
GLP-1
GLP-1 is being covered extensively, lately, with the popularity of products such as Ozempic and Mounjaro. It is being touted as a miracle. They are mostly known for abolishing appetite for extended periods of time, resulting in rapid weight (not necessarily fat) loss, as well as extremely unpleasant side effects.
Far from being a miracle, the synthetic GLP-1 products are a temporary fix at best, with the bounce back being severe.
GLP-1 agonists imitate a hormone called GLP-1 (Glucagon-Like Peptide 1). Activating the GLP-1 receptor (usually by means of eating) triggers an insulin release from the pancreas as well as an immediate blunting of appetite (you know, since you just ate and all). The insulin “unlocks” the cells of the body allowing for those recently ingested nutrients to enter the cells to be burned (in the case of sugar), stored (as either glycogen or fat), or used for repair or building new tissue (in the case of protein.)
Normally this is essential for life to continue, as a bunch of sugars, etc rolling around in the circulation is not only useless for body functions but damaging to tissues.
Now, while blood sugar levels are high, and while insulin (released by the pancreas in response to those sugar levels) is circulating, the body will not burn fat. Why is that? Well, because the body burns fat in response to low fuel levels – notably not enough glucose (sugar) to meet the required demands such as exercise, hunting, fleeing from predators, etc.
Glucagon (related to GLP-1) is a dominant hormone that suppresses appetite. So you have something the clears blood sugar, which enables fat burning, and inhibits appetite. Short term it is quite effective, but it is simply not sustainable long term. Or is it?
EDIT: Quick aside. Every hormone in our body, once secreted, must also be broken down and eliminated by enzymes. In the case of GLP-1, the enzyme is called DPP4 (Dipeptidyl peptidase 4)
Insulin/Insulin Resistance and Obesity
As mentioned above, Insulin is released by the pancreas when elevations in blood sugar, and some amino acids (protein) are detected. This immediately shuts down fat burning, and reverses the process to begin storing nutrients in any available tissue, including fat cells.
The curse of modern excess, with high calorie foods readily available, is that people tend to “snack” constantly. We wind up pushing a steady stream of mostly carbohydrates into our bodies, which triggers a near constant insulin elevation. Now, much like lightly brushing your skin in the same spot for a long time, what initially feels good eventually deadens to that stimulation until you don’t feel much of anything. Insulin and cells are the same way. With insulin constantly “knocking” on those cells to open up and take in more nutrients, eventually the cells start ignoring that knocking, instead just turning up the TV volume and hoping that pesky insulin just goes away. Now without anywhere to store those nutrients (usually carbs/sugars) they just circulate around causing damage to nerves, blood vessels, and pretty much anything else they touch. The consequences can be miserable, crippling, and even deadly, and most certainly unattractive.
Adiponectin/Leptin/Adropin
Adiponectin
Adiponectin was named, a bit incorrectly, because it was thought to be secreted only by White Adipose (that ugly stubborn fat) as a balance for obesity. We now know that Adiponectin is also secreted by metabolically active tissues such as Skeletal muscle and the liver. It acts as an insulin sensitizer (which combats insulin resistance covered above) and acts to ramp up metabolism when adiposity (body fat %) becomes excessive. By increasing fatty acid oxidation, it works to keep our bodies within a reasonable body fat range. Usually.
Leptin
The complexity of Leptin could take up dozens of pages and still not do it justice. Also secreted primarily by fat cells, Leptin acts both of peripheral tissues, but more importantly acts on the brain to control metabolism and appetite. Say you are hungry, so you grab a pizza. You eat a slice, maybe 2, and the Leptin signal to your brains says “Ok, that’s all the fuel you need” and shuts off your hunger signal. But let’s just say that this pizza is really, REALLY good...so you ignore it and keep eating. Eventually (not that first time, but if you overeat chronically) your brain will also start to ignore the Leptin “I’m not hungry” signal (like Insulin resistance, this is called Leptin Resistance) and instead your brain will start to signal that you are hungry. All…..The….Time.
Adropin
Adropin is a new player entering the game, or at least our knowledge of it. Discovered only in 2008, Adropin is turning out to be one of the key players (with the previous 2) in balancing energy storage and usage. Adropin is secreted primarily by the liver and the brain, with lower levels secreted by the heart and the GI tract. Now, excess adiposity (obesity) massively lowers the body’s secretion of Adropin. Now, Adropin is being studied more and more, with these studies indicating that it is another key controller of metabolism and energy balance. As another piece in the metabolic puzzle, you can start to see how Insulin resistance, Adiponectin, Leptin/Leptin resistance, and obesity controlled suppression of Adropin lead to the mess that the Modern Western World (and increasingly other cultures) are experiencing with regards to health problems, lowered life span, a ridiculous number of prescriptions that don’t solve any problems, obesity, and overall lower quality of life. Of Note: Adropin seems to be a highly dynamic hormone. Though initially, rises in Adropin cause a reduction of body fat, if accompanied by overfeeding high fat or high sugar foods, the rise can exacerbate fat gain. Lesson – be mindful of your diet.
Lipolysis
Before we get too far into this, let’s give you a quick lesson on Lipolysis. Despite some misinformation out there, lipolysis is not actually a process of burning fat. Lipolysis is taking the fat that is stored in your fat cells and “squeezing” it out, like juice from an orange. These freed fatty acids then take a few laps around the circulation, checking out the scenery and looking for somewhere to actually be burned, then if there is not enough demand they just boogie right back into that fat cell and you’ve accomplished nothing. And again, if the hormones are knocking but the cells won’t let them in, then that fat you want so badly to burn simply...won’t be.
Lipolysis is triggered by a reasonably simple process. Catecholamines (dopamine, adrenaline, etc) combine with something called Hormone Senative Lipase and cAMP (and a few others...so simple is relative) to signal to those fat cells that we need fuel STAT (usually in response to fight or flight).
Once released from the fat cells, as mention, it needs a destination. Moving on…
cAMP
This is a bit tricky. CAMP, or cyclic Adenosine Monophosphate, communicates to the rest of your body your “energy state”. When your fuel stores are full of a form called Adenosine TriPhosphate, then your body prefers to run on that. Ripping a phosphate group off (sort of like a road flare being scraped on the pavement) releases a tremendous amount of energy, to allow your muscles to move, etc. When the first phosphate is taken, you are left with Adenosine DiPhosphate (di meaning two). There is still energy potential there, though less. When that second phosphate is removed, you are left with Adenosine MonoPhosphate (mono meaning one) and a cascade occurs to signal your body that it needs to replenish. Body Fat is one of the first places it goes to replenish, which is what we are shooting for.
As mentioned in the Lipolysis section, cAMP is required for lipolysis.
Side Note: Adenosine, without any phosphates, causes your body to get very tired (which makes sense since energy levels would be low). Caffeine blocks Adenosine from docking with its receptor, which is how it keeps you awake.
Last edited:
killing me 
