Usually, the decision for someone to use Sustain over Clomid or Nolva is to avoid the side-effecs of these SERMs. I personally don’t use either clomid or nolva due to there extensive toxic profile. (liver toxic, ocular toxic, genotoxic, libido suppressing, ect)
Clomid and Nolva are synthetic estrogens that have super-estrogen effects, anti-estrogenic effects, and screwy DNA damaging effects depending on the bodily tissue and metabolite. I went through exhaustive research with these compounds, and the closer you look at them, the more damaging they appear.
Consider this – We are about to enter the 3th major generation of medical SERMS. Clomid and Nolva are first generation SERM’s with the worst side effect profile, toremifene and raloxifene are second generation, and bazedoxifene, arzoxifene, and lasofoxifene are 3rd generation. Each generation improves upon the previous generation by being less toxic. That should tell you something. I can post a full referenced write up on this.
Everyone who has replaced their typical SERMs with Sustain has been more than happy. So far, everyone claims to actually be recovering better with Sustain, compared to clomid or nolva. While I do believe Sustain to be equally effective for post cycle therapy purposes, I think people’s results are so positive because they are simply suffering from less side effects. (Contrary to popular believe, post cycle sexual dysfunction is often a result of PCT drugs such as clomid or nolva, not low testosterone)
Info from Eric from PP.
The issue is simply that you're swimming in 'uncharted waters'.
Resveratrol is a great ER antagonist, but is still relatively new to the science community.
Has it been clinically shown to modulate ER's?
Yes.
Has it been clinically shown to increase testosterone?
Yes.
Has it been clinically shown to block ER's in breast tissues?
You betcha.
Has it been clinically shown to quickly return the body to homeostasis following a suppressive anabolic steroids cycle?
No.
Will it assist in returning the body to homeostasis following a steroids cycle?
Probably.
Is there any information comparing it to a SERM for use in returning the body to homeostasis after a suppressive anabolic steroids cycle?
No.
You're replacing a chemical that was designed specifically to block estrogen receptors, with a chemical found in grapes and peanuts that coincidentally has the ability to bind to ER-alpha and ER-beta without promoting an estrogenic effect.
Info from the sinner both of whom design products with Trans-Resveratrol in it.