Drol question
- Thread starter Jarconis
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paperbolix
New member
it converts to dihydrotestosterone (DHT) which causes the hairloss
dg806
Enologist/Brewmaster/Damn good guy
From BC's steriod profile.................If you can translate this in english, please do!!
Other notes I should mention about this compound are that oxymetholone's androgenic qualities are not linked to a 5-alpha reduced form. As a matter of fact it shows rather poor interaction with the 5AR enzyme, making it futile to treat a possible increase in hair loss with 5-alpha reductase-blocking products such as finasteride. Its androgenic component stems from the fact that oxymetholone is very much like Dihydrotestosterone were it not for the added 2-hydroxymethylene group. Since this group can be metabolically removed, that would leave methyl-DHT. A compound with a weaker affinity for the androgen receptor than straight DHT, but more active and with less affinity for the DHT-reducing enzyme 3beta hydroxysteroid dehydrogenase. Ultimately resulting in much stronger, instead of weaker androgenic effects than compounds that are actively 5-alpha reduced. This evens out largely, because the distribution is even across the body, where 5-alpha-reduction usually concentrates more potent androgenic forms in androgen responsive tissue such as skin and scalp
Other notes I should mention about this compound are that oxymetholone's androgenic qualities are not linked to a 5-alpha reduced form. As a matter of fact it shows rather poor interaction with the 5AR enzyme, making it futile to treat a possible increase in hair loss with 5-alpha reductase-blocking products such as finasteride. Its androgenic component stems from the fact that oxymetholone is very much like Dihydrotestosterone were it not for the added 2-hydroxymethylene group. Since this group can be metabolically removed, that would leave methyl-DHT. A compound with a weaker affinity for the androgen receptor than straight DHT, but more active and with less affinity for the DHT-reducing enzyme 3beta hydroxysteroid dehydrogenase. Ultimately resulting in much stronger, instead of weaker androgenic effects than compounds that are actively 5-alpha reduced. This evens out largely, because the distribution is even across the body, where 5-alpha-reduction usually concentrates more potent androgenic forms in androgen responsive tissue such as skin and scalp
DR.D
Well-known member
Jarconis said:
It's more of a sebaceuos gland thing. Doesn't it make you oily? It's one of the worst, be I never lost hair on it. Also, it's already 5-reduced if you think about it. A novel idea is that anatomical changes in the vasculature of the skin may lead to hair loss in prone people.
paperbolix
New member
Well it says in one of my books:
{It is important to note that anadrol does exhibit some tendency to convert to DHT, although this does not occur via the 5-alpha reductase enzyme (responsible for altering testosterone to form DHT) Anadrol is already a DHT based steroid. Aside from the c-17 it differs to DHT only by the addition of 2-hydrozymethylene group.}
OK not sure I fully understand that but basically it turns to DHT, just not all of it does but consider with anadrol your taking alot - 50-100mg a day so you have these high androgenic sides-oily skin, acne, hairloss.
{It is important to note that anadrol does exhibit some tendency to convert to DHT, although this does not occur via the 5-alpha reductase enzyme (responsible for altering testosterone to form DHT) Anadrol is already a DHT based steroid. Aside from the c-17 it differs to DHT only by the addition of 2-hydrozymethylene group.}
OK not sure I fully understand that but basically it turns to DHT, just not all of it does but consider with anadrol your taking alot - 50-100mg a day so you have these high androgenic sides-oily skin, acne, hairloss.
Jarconis said:
lifted
Well-known member
paperbolix said:
Yeah, it means that it acts through Methyl-DHT...and that is an even stronger form....this is because of hte additiion of the 2-hydro group that merely alters it a bit when compared to DHT. And since 5AR types 1 and 2 concentrate the AR response in mostly skin and scalp, M-DHT concentrates them evenly throughout the whole body....