Dosage for weight ratio

[rngkng]

Hi, I am 6 240 and just started a cycle of X-Mass at 3 caps per day. Should I take more since I way more or should I stick with 3 per day and stack it with another compound and if so which one would gel with the X-Mass? Thanks

 

[rngkng]

Grexx?Anybody?

 

[ripped218]

Grexx and others usually say M-trn stacks pretty well with all the other Generic Labz products ,whatever kind of results you are looking for.I would probably add that then up the dosage of x-mass.

 

[rngkng]

Thanks alot for the reply.

 

[grexx]

I don't know why guys get hung up on the thought that the bigger you are, the more you need. Try 4 mg/day of the mega-trn and 2-3 caps of the x-mass per day for 4 weeks. If you are fresh, your receptors are clean and your weight will have nothing to do with the results.

 

[stxnas]

If you are fresh, your receptors are clean and your weight will have nothing to do with the results.

Pardon my ignorance Grexx, but what do you mean by "fresh"? Do you mean that as in somebody that has never used or do you mean "fresh" as in a span of time has been taken off?--say 3 months/6 months/1 yr?

 

[size]

Fresh receptors is a myth. However, I do agree that since you are bigger it does not mean that you msut use a higher dosage. There are many variables that effect dosage levels, from experience, responsiveness, nutrition, goals, etc.

 

[stxnas]

Fresh receptors is a myth.

Thanks Size. Could you clear this up some more for me though? I'm very analytical!

This is a myth in what way? Is it not true that once having used you don't react as much the next time or is it not true that you can wait x amount of months/days/years after using and it's like you're receptors are that of a newb?

 

[size]

This is a myth in what way?

Myth is probably not the correct word, mistake is probably better. Many people fall under the assumption that androgen receptors down regulate. The reason being that many people just assume that since some receptors, such as beta-receptors(i believe) down regulate than so will other. However, this is not the case.
People often assume that lack of gains or slowing of gains can be attributed to down regulation or saturation of androgen receptors. However, a more likely limiting factor is simply the number of androgen receptors; this will vary from person to person. Hence, some people seemingly respond amazingly while other on the same dosage respond to a lesser extent, assuming all things equal.


A quote from Bryan Hayc0ck, "Simply stated, supraphysiological levels of testosterone give rise to increased numbers of myonuclei and thereby an increase in the number of total androgen receptors per muscle fiber."


More
Antonio J, Wilson JD, George FW. Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles. J Appl Physiol. 1999 Dec;87(6):2016-9.
"…it is intriguing to speculate that the upregulation of AR levels via the administration of pharmacological amounts of androgens might convert some muscles that normally have a minor or no response to muscles with enhanced androgen responsiveness"

 

[Mulletsoldier]

Thanks Size. Could you clear this up some more for me though? I'm very analytical!

This is a myth in what way? Is it not true that once having used you don't react as much the next time or is it not true that you can wait x amount of months/days/years after using and it's like you're receptors are that of a newb?

When they say receptors they mean your AR receptors. It is a common held belief that through continual hormonal use your AR receptors will downgrade, rendering the substance ineffective to your body. But, research has shown your AR recpetors regenerate constantly, within a day or two. In fact, in most cases the reason why a substance stops working for an individual is they do not continually tailor their diet to their new found mass.

 

[SwollOnIron]

hmmm....not so sure about the size thing....hormones in general are dose/wt dependent.

Here is a source I quickly googled to illustrate this point: [Durabolin injection] "suggest highly dose-dependent effects on other parameters such as body weight, fat deposition and muscle protein synthesis."

ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1952814&dopt=Abstract[/url]

 

[size]

hormones in general are dose/wt dependent.

I do not think anyone is debating that hormones are dosage dependent. The discussion movement was in regard to the common mistake about androgen receptor downregulation.