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OMG that is so true! Also when I first visited the Pearl Harbor memorial, they ask for everyone to be silent out of respect. Well, all of the Asians in my group were rattling off loudly in their home language. It’s posted in various languages to be silent.
I get this. Went I went to the Hiroshima bomb site, it was the American tourists who were being disrespectful at the sites.

I tend to find people in general are less respectful of others cultures, even if it is completely unintentional.

Foreigners were also the ones talking loudly on the trains and in elevators etc which is a well established quiet places
 
The majority of vaccine side effects occur within 6 weeks of the dosage.
and as far as i know no one outside the test group has got 2nd shot?

heard that several people are having alergic reaction from shot?
 
I get this. Went I went to the Hiroshima bomb site, it was the American tourists who were being disrespectful at the sites.

I tend to find people in general are less respectful of others cultures, even if it is completely unintentional.

Foreigners were also the ones talking loudly on the trains and in elevators etc which is a well established quiet places
i love it when i go somewhere and spanish speakers are practically shouting in spanish...i start talking loudly to my wife in tagalog [even though she doesn't speak it] and they look at me like i am the one being rude, lol.
 
Did you guys/gals/neutrals hear about the new more dangerous COVID-1984 strain?

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He said there was “nothing to suggest” that the mutant would cause more serious disease, though he did say that the mutation is linked to the virus’ spike protein, which is instrumental in allowing it to reproduce and spread and is the target of many leading vaccines currently in development, including the Pfizer-BioNTech one currently being rolled out in the U.K. and the U.S..

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That’s it....I’m checking out. Done! Where’s my vodka?!
 
That a nice opinion with zero relevance and zero ways to ever prove true. Even more so in a situation where new technology against a new virus is being used.
hey, he saw it on facebook-it must be true!!!!
 
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Well, I was upset that I didn’t get to visit my sister the other day but she and my brother in law just tested positive. So far, my brother, older sister, little sister, and brother in law have caught it. I swear, it’s like a game of tag, you’re running but it will eventually catch you.
 
'officials identify new strain of covid-19 in UK'


so what does this do to vaccines....????
 
did i just read that covid 19 has 'MUTATED'?

I dont know, personally I think there probably are hundreds of strains by now, and Im still not sold the vaccine is going to fix our problems long term even though what Ive read seems to show the new technology should take care of them all.
 
I dont know, personally I think there probably are hundreds of strains by now, and Im still not sold the vaccine is going to fix our problems long term even though what Ive read seems to show the new technology should take care of them all.
how many years they been working on hiv?

almost a million people die from aids each year.
 
He said there was “nothing to suggest” that the mutant would cause more serious disease, though he did say that the mutation is linked to the virus’ spike protein, which is instrumental in allowing it to reproduce and spread and is the target of many leading vaccines currently in development, including the Pfizer-BioNTech one currently being rolled out in the U.K. and the U.S..

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That’s it....I’m checking out. Done! Where’s my vodka?!

The spike protein is what the virus uses to attach to and gain entry to our cells via the ACE-2 receptor. Based on everything ive seen and read, If it loses that it loses its binding affinity and therefore it’s infectivity in humans.
 
I dont know, personally I think there probably are hundreds of strains by now, and Im still not sold the vaccine is going to fix our problems long term even though what Ive read seems to show the new technology should take care of them all.

There are 6. Read it from an ID doc somewhere, dont know where. Believe it if you want, or dont. 🤷🏻‍♂️

how many years they been working on hiv?

almost a million people die from aids each year.

Not all viruses are identical. HIV doesnt get detected by the immune system very well due to how rapidly it mutates.

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Scientists HAVE been able to develop vaccines do many, many viruses. Why do you focus on the virus that is the most difficult one to design a vaccine against?
 
British scientists are trying to establish whether the rapid spread in southern England of a new variant of the virus that causes COVID-19 is linked to key mutations they have detected in the strain, they said on Tuesday.

In the case of SARS-CoV-2, these mutations are accumulating at a rate of around one to two mutations per month globally, according to the COG-UK genetics specialists.

“As a result of this on-going process, many thousands of mutations have already arisen in the SARS-CoV-2 genome since the virus emerged in 2019,” they said.


The majority of the mutations seen so far have had no apparent effect on the virus, and only a minority are likely to change the virus in any significant way - for example, making it more able to infect people, more likely to cause severe illness, or less sensitive to natural or vaccine-induced immune defences.

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So this is slightly more encouraging. Also, it is said that the vaccines are easily tweakable if need be. Not that I want to be getting them all the time. Personally, I think the main objective should be getting everyone through their first infection without worrying too much about the future. Once everyone builds some sort of immunity via a prior infection or vaccine, the less impact future mutations should have. Then again, who knows what other surprises China may have up their sleeve.
 
I get this. Went I went to the Hiroshima bomb site, it was the American tourists who were being disrespectful at the sites.

I tend to find people in general are less respectful of others cultures, even if it is completely unintentional.

Foreigners were also the ones talking loudly on the trains and in elevators etc which is a well established quiet places
Something I've noticed here in UK is africans on their mobile phone on public transport, holy f@ck it could be an hour journey and they wouldn't even take a breath, and i mean loud too. I'd love to be able to understand what they're saying cuz when i phone someone its 5 mins and I'm already out of stuff to say .
Btw i mean people actually from africa, not black people, i get that its a cultural thing not racial
 
There are 6. Read it from an ID doc somewhere, dont know where. Believe it if you want, or dont. 🤷🏻‍♂️

I personally would go with whats identified and official. Id wouldnt be surprised if there was a few more but thats me just guessing.
 
Did you guys/gals/neutrals hear about the new more dangerous COVID-1984 strain?
I just have to tell you, I truly enjoy how you call it COVID-1984! I’m going to start calling it that at work! Even better, I am going to start referring to it with the positive patients I see as COVID (insert patient birthdate). They won’t be able to hear me anyway, but at least I’ll get a chuckle out of it from underneath my N95.
The spike protein is what the virus uses to attach to and gain entry to our cells via the ACE-2 receptor. Based on everything ive seen and read, If it loses that it loses its binding affinity and therefore it’s infectivity in humans.
Yeah, I remain faithful/hopeful that the MOA behind the current vaccines will remain effective at least in terms of managing this ongoing initial crisis.
 
There are 6. Read it from an ID doc somewhere, dont know where. Believe it if you want, or dont. 🤷🏻‍♂️

From Ricky's post
"In the case of SARS-CoV-2, these mutations are accumulating at a rate of around one to two mutations per month globally, according to the COG-UK genetics specialists."

So is this different that what your talking about?
 
and as far as i know no one outside the test group has got 2nd shot?

heard that several people are having alergic reaction from shot?
Yeah, allergic reactions are uncommon (a few cases in several hundred thousand) but also quite manageable.
 
From Ricky's post
"In the case of SARS-CoV-2, these mutations are accumulating at a rate of around one to two mutations per month globally, according to the COG-UK genetics specialists."

So is this different that what your talking about?
Yeah, what I don’t get from that article is how does one or two mutations per month since let’s just say December of 2019...equal many thousands of mutations? Yes, I am questioning my own source...haha!

In the case of SARS-CoV-2, these mutations are accumulating at a rate of around one to two mutations per month globally, according to the COG-UK genetics specialists.

“As a result of this on-going process, many thousands of mutations have already arisen in the SARS-CoV-2 genome since the virus emerged in 2019,” they said.


I’m not convinced anyone knows how many (if any) mutations there have been and then actually identified. Maybe the virus just feels like dressing a bit different on a particular day, and the scientists mistake it for something new.
 
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Yeah, what I don’t get from that article is how does one or two mutations per month since let’s just say December of 2019...equal many thousands of mutations? Yes, I am questioning my own source...haha!

In the case of SARS-CoV-2, these mutations are accumulating at a rate of around one to two mutations per month globally, according to the COG-UK genetics specialists.

“As a result of this on-going process, many thousands of mutations have already arisen in the SARS-CoV-2 genome since the virus emerged in 2019,” they said.


I’m not convinced anyone knows how many (if any) mutations there have been and then actually identified. Maybe the virus just feels like dressing a bit different on a particular day, and the scientists mistake it for something new.
The genome mutates at that approximate rate, but it's not like 1 single virus is the only 1 mutating.
 
Something I've noticed here in UK is africans on their mobile phone on public transport, holy f@ck it could be an hour journey and they wouldn't even take a breath, and i mean loud too. I'd love to be able to understand what they're saying cuz when i phone someone its 5 mins and I'm already out of stuff to say .
Btw i mean people actually from africa, not black people, i get that its a cultural thing not racial
Yeah exactly. It's cultural things. Some people adapt better to others cultures, and some are simply oblivious.

In Japan it is rude to walk and eat at the same time. Took me a few days to notice that.
 
is it wrong to question the safety of this vaccine?

seriously, no one on here has even had the 2nd shot yet but everyone seems so eager to say how safe it is.....i can see it coming, people like me who question this vaccine will be villianized--- get the damned vaccine, fool!!!
 
I personally would go with whats identified and official. Id wouldnt be surprised if there was a few more but thats me just guessing.

From Ricky's post
"In the case of SARS-CoV-2, these mutations are accumulating at a rate of around one to two mutations per month globally, according to the COG-UK genetics specialists."

So is this different that what your talking about?

Not gonna lie i dont know how they officially classify a new strain. Id imagine there has to be a certain # of mutations that are significant enough to change the way the virus behaves in order to be classified as a new strain, but thats honestly a guess.

Virology is insane. Virologists literally have formulas that can calculate the rate at which different viruses mutate. I dont even pretend to understand all of that shît.

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^ just skim that. The people working on figuring out this virus know that kind of minutiae off* the top of their heads.
 
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is it wrong to question the safety of this vaccine?

seriously, no one on here has even had the 2nd shot yet but everyone seems so eager to say how safe it is.....i can see it coming, people like me who question this vaccine will be villianized--- get the damned vaccine, fool!!!
It is 100% OK to question it. Absolutely.

Just make sure the criticisms are actually based on evidence (or a lack thereof). Also recognize that vaccines and viruses are exceptionally complex, so listening to the right information is also important.

For example, criticizing a vaccine because Bill Gates wants to microchip the entire planet is a bit far fetched. Being a bit concerned about an allergic reaction is more valid.
 
is it wrong to question the safety of this vaccine?

seriously, no one on here has even had the 2nd shot yet but everyone seems so eager to say how safe it is.....i can see it coming, people like me who question this vaccine will be villianized--- get the damned vaccine, fool!!!

Its rushed, warp speed money came in, people want results, problems do exist for those high risk, obviously they are going to try to pull of the biggest undertaking since WWII and this whole shyt is nuts.

Id guess the vax is safe for most, but I have doubts about its long term effectiveness. I dont think the zombiepocolyse is happening.

Im completely against forced vaccination, Id rather gamble with my own immune system, been taking good care of it.
 
Not gonna lie i dont know how they officially classify a new strain. Id imagine there has to be a certain # of mutations that are significant enough to change the way the virus behaves in order to be classified as a new strain, but thats honestly a guess.

Virology is insane. Virologists literally have formulas that can calculate the rate at which different viruses mutate. I dont even pretend to understand all of that shît.

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^ just skim that. The people working on figuring out this virus know that kind of minutiae of the top of their heads.
I'm working through a virology text book at the moment and it is very, very complex.
 
Yeah, what I don’t get from that article is how does one or two mutations per month since let’s just say December of 2019...equal many thousands of mutations? Yes, I am questioning my own source...haha!

In the case of SARS-CoV-2, these mutations are accumulating at a rate of around one to two mutations per month globally, according to the COG-UK genetics specialists.

“As a result of this on-going process, many thousands of mutations have already arisen in the SARS-CoV-2 genome since the virus emerged in 2019,” they said.


I’m not convinced anyone knows how many (if any) mutations there have been and then actually identified. Maybe the virus just feels like dressing a bit different on a particular day, and the scientists mistake it for something new.
This is not directed at you Ricky but just happens to be the comment that has some of the things I address:

individual/several mutations are not necessarily the same as different strains. There’s a piece of literature that found out of like 45k samples that there were around 7 mutations per sample. Keep in mind the SARS-cov-2 genome is 29.8-29.9k nucleotides long. This new strain is actually a specific set of 17 mutations or changes that make it a specific strain. Maybe this helps clarify the comment about six strains (each with their own combination of several mutations, that distinguish them as strains). With regards to mutations, the UK has documented 4000 mutations in the spike protein. In September there were 12,000 documented mutations according to a study in nature. The question is whether or not the mutations are meaningful. COG-UK is a good resource for this as they’ve sequenced 140,000 SARS-cov-2 samples from COVID-19 positive patients. Disclaimer: I’m not a virologist. This is all my opinion based on having a scientific background and that I like reading about this. See jswains comment about virology and the technicality understanding required for these things.

There are many regions of the spike protein that the immune system actually generates antibodies to. Generally 5-20 antibodies for something like the one spike protein, each for different regions. So, it’s unlikely that select mutations to isolated regions of the spike protein will render ALL antibodies ineffective. In fact, I was reading about someone’s preliminary structural model of the mutation in question, N501Y. For those unsure of what that means it’s a substitution of asparagine (N) for Tyrosine ( at position 501. The asparagine in a 3D model of S/spike protein binding to ACE-2 demonstrates the (N) backbone carbonyl interacting with an internal side chain. The side chain is close in proximity to ACE-2 and doesn’t seem to interact with anything else around it and sticks out, which the individual posited wouldn’t actually change the confirmation of the protein. This is because the N to Y may not position the OH group in tyrosine to potentially interact with any hydrogen bond acceptors. IF this interaction occurred, there might be something there, but it doesn’t look like it from this model, apparently. Say for arguments sake that this did happen and the antigen actually escaped the antibody for that region of the spike protein, there’s up potentially up to 20 more antibodies for other regions of the spike protein that it would have to equally overcome with separate mutations.

There’s a murine lung cell model where the N501Y mutation is associated with Increased virulence and receptor docking, but a vaccine candidate selective for the based on the wild type genome (no N501Y mutation) is still protective against the infection in N501Y murine virus. Yes, it’s a mouse model, but combined with the info above we can tell there’s not enough info to say anything definitive, either way, at this point. My answer is pretty much we don’t know yet. Everything is correlation at this point and while it should and will be monitored for changes to figure out what the new strain means, I am personally waiting for definitive info to come out.
 
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I'm working through a virology text book at the moment and it is very, very complex.

Arent they just learning as they are going along? I mean the text book is nothing set in stone here.
 
Arent they just learning as they are going along? I mean the text book is nothing set in stone here.
It's not on Covid 19, just on the concepts of virology and modelling
 
is it wrong to question the safety of this vaccine?

seriously, no one on here has even had the 2nd shot yet but everyone seems so eager to say how safe it is.....i can see it coming, people like me who question this vaccine will be villianized--- get the damned vaccine, fool!!!
Well, it’s new technology, so there is that. However, did you read the ingredients for the Pfizer vaccine and how it works? It has no preservatives or heavy metals- which is a partially to blame for stirring up vaccine controversy in general. Other than that, the ingredients are rather benign when you consider that it’s a vaccine. If you read through the MOA- it’s pretty damn impressive and solid if you ask me! That’s part of why I decided to get it.

You know that you have to gain a degree of immunity one way or another at some point. You have to ask yourself if you want it to sneak up on you when you least expect it? I know you are a healthy guy, but you also know that you can transmit it to your loved ones before you even feel symptomatic. Are your loved ones as healthy as you are? Maybe you or one of your loved ones are one of those really unfortunate people that are considered low risk, but happen to come down with a severe and debilitating China virus illness anyway? Or have lingering health consequences from mild illness.

Would it be worth it for you to feel some peace of mind from gaining immunity from a vaccine for you and your family you are in close contact with? I don’t know that answer and it’s not mine to make, but you should definitely consider the options. I know I joke a lot about work and such, but statistics don’t speak much on some level. Not everyone in the hospital with the China virus is half dead from a nursing home. Many are not that much older or different than myself, and I see them going off to rehab or hospice on oxygen. I say to myself that there are no guarantees that couldn’t happen to me.

So after my second dose of the Pfizer vaccine- I will be able to give a better short term assessment on that. In the meantime, I think you know what I would recommend to you and already have to my loved ones.

OK, so yeah....so much for me not peddling the vaccine 🤭
 
This is not directed at you Ricky but just happens to be the comment that has some of the things I address:

individual/several mutations are not necessarily the same as different strains. There’s a piece of literature that found out of like 45k samples that there were around 7 mutations per sample. Keep in mind the SARS-cov-2 genome is 29.8-29.9k nucleotides long. This new strain is actually a specific set of 17 mutations or changes that make it a specific strain. This should clarify the comment about six strains (each with their own combination of several mutations, that distinguish them as strains). With regards to mutations, the UK has documented 4000 mutations in the spike protein. In September there were 12,000 documented mutations according to a study in nature. The question is whether or not the mutations are meaningful. COG-UK is a good resource for this as they’ve sequenced 140,000 SARS-cov-2 samples from COVID-19 positive patients. Disclaimer: I’m not a virologist. This is all my opinion based on having a scientific background and that I like reading about this. See jswains comment about virology and the technicality understanding required for these things.

There are many regions of the spike protein that the immune system actually generates antibodies to. Generally 5-20 antibodies for something like the one spike protein, each for different regions. So, it’s unlikely that select mutations to isolated regions of the spike protein will render ALL antibodies ineffective. In fact, I was reading about someone’s preliminary structural model of the mutation in question, N501Y. For those unsure of what that means it’s a substitution of asparagine (N) for Tyrosine ( at position 501. The asparagine in a 3D model of S/spike protein binding to ACE-2 demonstrates the (N) backbone carbonyl interacting with an internal side chain. The side chain is close in proximity to ACE-2 and doesn’t seem to interact with anything else around it and sticks out, which the individual posited wouldn’t actually change the confirmation of the protein. This is because the N to Y may not position the OH group in tyrosine to potentially interact with any hydrogen bond acceptors. IF this interaction occurred, there might be something there, but it doesn’t look like it from this model, apparently. Say for arguments sake that this did happen and the antigen actually escaped the antibody for that region of the spike protein, there’s up potentially up to 20 more antibodies for other regions of the spike protein that it would have to equally overcome with separate mutations.

There’s a murine lung cell model where the N501Y mutation is associated with Increased virulence and receptor docking, but a vaccine candidate selective for the based on the wild type genome (no N501Y mutation) is still protective against the infection in N501Y murine virus. Yes, it’s a mouse model, but combined with the info above we can tell there’s not enough info to say anything definitive, either way, at this point. My answer is pretty much we don’t know yet. Everything is correlation at this point and while it should and will be monitored for changes to figure out what the new strain means, I am personally waiting for definitive info to come out.
Wow, that’s quite the response...thanks!

Overall, I would say that sounds pretty darn promising in regard to the long term efficacy of the vaccine in light of mutations...
 
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This is not directed at you Ricky but just happens to be the comment that has some of the things I address:

individual/several mutations are not necessarily the same as different strains. There’s a piece of literature that found out of like 45k samples that there were around 7 mutations per sample. Keep in mind the SARS-cov-2 genome is 29.8-29.9k nucleotides long. This new strain is actually a specific set of 17 mutations or changes that make it a specific strain. Maybe this helps clarify the comment about six strains (each with their own combination of several mutations, that distinguish them as strains). With regards to mutations, the UK has documented 4000 mutations in the spike protein. In September there were 12,000 documented mutations according to a study in nature. The question is whether or not the mutations are meaningful. COG-UK is a good resource for this as they’ve sequenced 140,000 SARS-cov-2 samples from COVID-19 positive patients. Disclaimer: I’m not a virologist. This is all my opinion based on having a scientific background and that I like reading about this. See jswains comment about virology and the technicality understanding required for these things.

There are many regions of the spike protein that the immune system actually generates antibodies to. Generally 5-20 antibodies for something like the one spike protein, each for different regions. So, it’s unlikely that select mutations to isolated regions of the spike protein will render ALL antibodies ineffective. In fact, I was reading about someone’s preliminary structural model of the mutation in question, N501Y. For those unsure of what that means it’s a substitution of asparagine (N) for Tyrosine ( at position 501. The asparagine in a 3D model of S/spike protein binding to ACE-2 demonstrates the (N) backbone carbonyl interacting with an internal side chain. The side chain is close in proximity to ACE-2 and doesn’t seem to interact with anything else around it and sticks out, which the individual posited wouldn’t actually change the confirmation of the protein. This is because the N to Y may not position the OH group in tyrosine to potentially interact with any hydrogen bond acceptors. IF this interaction occurred, there might be something there, but it doesn’t look like it from this model, apparently. Say for arguments sake that this did happen and the antigen actually escaped the antibody for that region of the spike protein, there’s up potentially up to 20 more antibodies for other regions of the spike protein that it would have to equally overcome with separate mutations.

There’s a murine lung cell model where the N501Y mutation is associated with Increased virulence and receptor docking, but a vaccine candidate selective for the based on the wild type genome (no N501Y mutation) is still protective against the infection in N501Y murine virus. Yes, it’s a mouse model, but combined with the info above we can tell there’s not enough info to say anything definitive, either way, at this point. My answer is pretty much we don’t know yet. Everything is correlation at this point and while it should and will be monitored for changes to figure out what the new strain means, I am personally waiting for definitive info to come out.
Are you going to take one of the vaccines, and what is your risk-benefit analysis?

What else do you know, where do you come from? Are you a prophet?
 
Wow, that’s quite the response...thanks!

Overall, I would say that sounds pretty darn promising in regard to the long term efficacy of the vaccine in light of mutations...
You’re welcome! Like I said most of it wasn’t directed towards you as much as I just kept typing after the response to your comment since it seems like something everyone here has been talking about, lol. I also appreciate you sharing your experiences with the vaccine on here. Anyway. I think it puts into perspective that a lot of people’s immediate fears about the effects on vaccine efficacy - most people see the msm headline about a new strain spreading faster (which actually could be a few factors, it might not be dissimilar to the D614G spike mutation where it appears to spread quickly but is not actually more clinically relevant. there’s just several factors at play and we need to figure out what it actually is. We will probably know a lot more soon). While it’s technically possible that a strain evolves to overcome all antibodies to every region of the spike protein, it’s not likely. Mutations/strains should be monitored for to make sure things don’t head that way, which is what is happening afaik. As long as they don’t head that way, people don’t need to panic every time we might see something come up when there’s not enough data available.
 
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Well, it’s new technology, so there is that. However, did you read the ingredients for the Pfizer vaccine and how it works? It has no preservatives or heavy metals- which is a partially to blame for stirring up vaccine controversy in general. Other than that, the ingredients are rather benign when you consider that it’s a vaccine. If you read through the MOA- it’s pretty damn impressive and solid if you ask me! That’s part of why I decided to get it.

You know that you have to gain a degree of immunity one way or another at some point. You have to ask yourself if you want it to sneak up on you when you least expect it? I know you are a healthy guy, but you also know that you can transmit it to your loved ones before you even feel symptomatic. Are your loved ones as healthy as you are? Maybe you or one of your loved ones are one of those really unfortunate people that are considered low risk, but happen to come down with a severe and debilitating China virus illness anyway? Or have lingering health consequences from mild illness.

Would it be worth it for you to feel some peace of mind from gaining immunity from a vaccine for you and your family you are in close contact with? I don’t know that answer and it’s not mine to make, but you should definitely consider the options. I know I joke a lot about work and such, but statistics don’t speak much on some level. Not everyone in the hospital with the China virus is half dead from a nursing home. Many are not that much older or different than myself, and I see them going off to rehab or hospice on oxygen. I say to myself that there are no guarantees that couldn’t happen to me.

So after my second dose of the Pfizer vaccine- I will be able to give a better short term assessment on that. In the meantime, I think you know what I would recommend to you and already have to my loved ones.

OK, so yeah....so much for me not peddling the vaccine 🤭

So your saying in your opinion a vaccine will equate to not being able to spread the virus even if the person who was vaccinated was in direct contact with the virus?
 
Would it be worth it for you to feel some peace of mind from gaining immunity from a vaccine for you and your family you are in close contact with? I don’t know that answer and it’s not mine to make, but you should definitely consider the options.

Then again if all high risk people took it, these people shouldnt need to worry about if healthy young people tax a vax or not, right? Well, Im not asking for a professional answer here, lol
 
So your saying in your opinion a vaccine will equate to not being able to spread the virus even if the person who was vaccinated was in direct contact with the virus?
Then again if all high risk people took it, these people shouldnt need to worry about if healthy young people tax a vax or not, right? Well, Im not asking for a professional answer here, lol
No, actually I kind of mispoke there. They haven’t been doing testing on the effectiveness of the vaccines in stopping transmission, yet they remain hopeful that it will. It’s kind of surprising this wasn’t studied. I suppose they had their hands full getting the studies done that were completed in that short timeframe. I did just find that the AstraZeneca vaccine did show that it helps prevent transmission. Since they all appear to give us the same line of immune defenses- I tend to think there is great hope there! If anyone is really on board with protecting themselves and their family with one if the vaccines, they all should get it as appropriate. Maybe @mavup has more insight on this!
 
Are we serious? But we’re not allowed to know if a coworker has AIDS/HIV?!?

Also, my coworker ate my food and put it back. Now I can’t eat from it and have to leave it in there long enough for her to think that I didn’t throw it out because I saw her eat it!!!!

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You’re welcome! Like I said most of it wasn’t directed towards you as much as I just kept typing after the response to your comment since it seems like something everyone here has been talking about, lol. I also appreciate you sharing your experiences with the vaccine on here. Anyway. I think it puts into perspective that a lot of people’s immediate fears about the effects on vaccine efficacy - most people see the msm headline about a new strain spreading faster (which actually could be a few factors, it might not be dissimilar to the D614G spike mutation where it appears to spread quickly but is not actually more infectious - there’s just several factors at play and we need to figure out what it actually is. We will probably know a lot more soon). While it’s technically possible that a strain evolves to overcome all antibodies to every region of the spike protein, it’s not likely. Mutations/strains should be monitored for to make sure things don’t head that way, which is what is happening afaik. As long as they don’t head that way, people don’t need to panic every time we might see something come up when there’s not enough data available.
Meh, taking the first shot was easy, and so was reporting that I received it! I’m fully prepared to feel like death for 12 hrs after the next one though. At least I can plan on it coming and drug myself!

Yeah, I keep reading that our best chances of the virus not making any major mutations is for people to get widely immunized. :sneaky:
 
Are we serious? But we’re not allowed to know if a coworker has AIDS/HIV?!?

Also, my coworker ate my food and put it back. Now I can’t eat from it and have to leave it in there long enough for her to think that I didn’t throw it out because I saw her eat it!!!!

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Are you sure there wasn’t another reason he was fired? This doesn’t have anything to do with BLM does it?
 
No, actually I kind of mispoke there. They haven’t been doing testing on the effectiveness of the vaccines in stopping transmission, yet they remain hopeful that it will. It’s kind of surprising this wasn’t studied. I suppose they had their hands full getting the studies done that were completed in that short timeframe. I did just find that the AstraZeneca vaccine did show that it helps prevent transmission. Since they all appear to give us the same line of immune defenses- I tend to think there is great hope there! If anyone is really on board with protecting themselves and their family with one if the vaccines, they all should get it as appropriate. Maybe @mavup has more insight on this!
Let me get back to you on this comment and the others. I need to find some of the research but off the top of my head, even without sterilizing immunity (which is what ax1 is referring to unless I’m misunderstanding his prompt), there’s a meta analysis that shows you’re 1/18 as likely to infect people when asymptomatic vs symptomatic and it looks like the vaccines at the very least have evidence for eliminating symptoms, while sterilizing immunity is to be determined. There’s also evidence that true asymptomatic spread is not common and instead it’s presymptomatic spread (no symptoms = no spread, symptoms = spread) but I will have to find those articles too. The idea being that even if we get no sterilizing immunity, if asymptomatic spread is highly unlikely to happen/asymptomatics are not actually infectious, a vaccine that makes people asymptomatic would still be incredibly effective in preventing transmission. I’ve read the research before just gotta go back an find it. Also, I won’t make a definitive statement, but I think it’s either oxford or AZ who in their trials tested for either sterilizing immunity or stopping transmission, and it was 60%. I’m half asleep and can’t remember at this point so don’t quote me on those numbers or which candidate it is, lol
 
I'm working through a virology text book at the moment and it is very, very complex.

You must be a lot of fun at a party :)

I always say the same about myself and the nerdy stuff I read.

Immunity itself makes my head spin. T cells, cytokines, interferons, oh my.

Arent they just learning as they are going along? I mean the text book is nothing set in stone here.

We understand how viruses work, so it isn't like starting from scratch. We also have a prior understanding of coronavirus. I think it can seem contradictory that our prior knowledge may have actually been a part of the disinformation that occurred in the beginning - we didn't know what path we were headed down, but we knew some of the possible paths could be this or that...

And to your question about immunity - it seems obvious it should have an impact. This is a big reason people push for heard immunity, right? If I cannot be used to replicate the virus, I cannot give it to someone else. And the vaccine should prevent the virus from being able to enter our cells...so it should be less likely to spread because any that gets in us will be handled vs. Being allowed to increase in size and create more to spread. I am not saying 100% cannot be spread by someone who has immunity, just a lot less likely - as Mavup said.

But I am just going with my own explanation here, no expertise implied.
 
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