DHEA derived cortisol blockers

[nattydisaster]

Why is it that 7-oxo dhea has poor oral bioavailability, but 7-hydroxy does not?

 

[nattydisaster]

Anyone?

 

[nattydisaster]

Is it because the stomach converts the keto group to a hydroxy, which only has about 10% conversion rate?

While this is true, it doesnt make any difference in cortisol inhibition, as the 7-hydroxy isnt what is inhibiting cortisol, but the 7-oxo after the 11b-HSD converts it back...


Am i talking to myself here?

 

[dpfisher]

I doubt most of us care about the "why" mostly just the "how"

 

[nattydisaster]

I doubt most of us care about the "why" mostly just the "how"

Either or would be good to know...

 

[nattydisaster]

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