Contest....

[rms80]

Sleep Experts Treat Medical Condition Behind Violent Sleep Sex


STANFORD, Calif. - In a new study, Stanford researchers describe a treatable medical condition which causes people to commit violent sexual acts in their sleep. Referred to as "sleep sex," the nocturnal activities cited in the study range from disruptive moaning to rape-like behavior toward bed partners.

The researchers believe this condition stems from glitches in brain waves during sleep. By bringing attention to the disorder, they hope the health-care community will recognize the problem as medical in origin rather than psychological. "Now doctors might know to ask patients about how they're sleeping," said Christian Guilleminault, MD, professor of psychiatry and behavioral sciences at the Stanford School of Medicine.

Guilleminault's study, released in the March/April issue of the journal Psychosomatic Medicine, outlined 11 patients with symptoms that included loud, disruptive moaning on one end of the scale and sexual assault on the other. Regardless of how unusual or violent the behavior, patients had no memory of the events the next morning.

Guilleminault divided the patients into three groups depending on the severity of their behavior. Those whose disturbances were simply annoying included two women who made sexual moaning sounds during the night. Though relatively harmless, one woman felt embarrassed and guilty that her moaning disturbed her spouse and children.

The second group consisted of a man and a woman whose disturbances placed them at physical risk. They experienced periods of violent masturbation that left bruising or soreness. The man also reported breaking two fingers trying to escape from restraints he had used to prevent the behavior.

The third group included six men and one woman who made unwanted - and sometimes violent - sexual advances on their bed partners while asleep. In one case, the patient tried to strangle his wife. A teenage child in the home heard the disturbance and called the police, eventually leading to a referral to the Stanford Sleep Clinic.

"What was surprising was the duration of the abnormal behavior and the fact that people weren't reporting it," Guilleminault said. One patient in the study had been aware of the unusual behavior for 15 years before talking about it with his doctor. "People have to realize that it's a medical problem and there is a treatment," he said.

Over the past 10 years, researchers have suspected that violent behavior during sleep is a sleep-related disorder, but they didn't have the facts to prove it. Although these cases sound psychological in origin, Guilleminault believes the underlying problem relates to sleep. Rather than quietly passing through the five phases of sleep - each of which has a classic brain-wave pattern - the patients in the study had unusual patterns during one of the sleep phases or short interruptions in their sleep. Sound and video recordings of the patients showed that the sleep-sex behavior took place during these hiccups in the sleep cycle. In addition, seven of the patients had a history of walking in their sleep.

In all cases except one, the sleep disturbances went away with sleep disorder treatments - the same ones that would prevent sleepwalkers from raiding the fridge at night. Therapy includes drugs in the same family as Valium and treatments used for breathing disturbances.

Guilleminault said each of the patients had additional emotional problems that may have altered the form their sleep disturbance took. "What your state of mind is will color the presentation," he said. But even if the patients had no emotional problems, he added, the underlying sleep disorder still would exist, though it may take the form of sleepwalking or talking in sleep.

Guilleminault added that because the sleep disorders were embarrassing, sufferers were less likely to complain and also didn't know where to turn for help with the problem. "The aggressor and the victim are often both in difficult situations and don't know how to express the problem," he said. "They feel that there is nowhere to turn."

---Stanford University Medical Center

Damn!!!

 

[Vitruvian]

All the others are funny and strange... but this one is really really wierd. I mean, you kinda expect SOMEONE out there to be attacked by a rooster or river otter... by I sure as **** never expected Mallard ducks would be into Homosexual Necrophilia. :rofl:

There's a little town within an hour of me.... we always joke about how at this really nice park they have there, all the mallards are boys. Paired off too. Just everyday gay duck hangout I guess.............

 

[kjkriston]

ETA on the lucky winner being announced?

 

[brass monkey]

There's a little town within an hour of me.... we always joke about how at this really nice park they have there, all the mallards are boys. Paired off too. Just everyday gay duck hangout I guess.............

M R ducks
L IL B

 

[jmh80]

M R Not
O S A R

 

[jasonschaffin]

A case of successful management of recurrent bacterial vaginosis of neovagina after male to female gender reassignment surgery.

* Jain A,
* Bradbeer C.

Department of Genito-Urinary Medicine, Lambeth Wing, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK. [email protected]

As sex reassignment surgeries become common and advanced, doctors are more likely to encounter cases with 'different' anatomy. Due to variations in examination and management as compared with non-transsexual patients, these cases generally prove challenging to the physicians. We present a case of recurrent bacterial vaginosis (BV) of neovagina in a transsexual patient successfully managed by using metronidazole gel and occasional douching. This case illustrates the difference in the microscopy of vaginal flora and management of BV in transsexual as compared with non-transsexual women.

PMID: 17331294 [PubMed - in process]





Genital Sensitivity After Sex Reassignment Surgery in Transsexual Patients.

* Selvaggi G,
* Monstrey S,
* Ceulemans P,
* T'sjoen G,
* De Cuypere G,
* Hoebeke P.

From the Departments of *Plastic Surgery, daggerUrology, double daggerEndocrinology, and section signPsychiatry, Ghent University Hospital, Gent, Belgium.

BACKGROUND:: Tactile and erogenous sensitivity in reconstructed genitals is one of the goals in sex reassignment surgery. Since November 1993 until April 2003, a total of 105 phalloplasties with the radial forearm free flap and 127 vaginoclitoridoplasties with the inverted penoscrotal skin flap and the dorsal glans pedicled flap have been performed at Ghent University Hospital. The specific surgical tricks used to preserve genital and tactile sensitivity are presented.In phalloplasty, the dorsal hood of the clitoris is incorporated into the neoscrotum; the clitoris is transposed, buried, and fixed directly below the reconstructed phallic shaft; and the medial and lateral antebrachial nerves are coapted to the inguinal nerve and to one of the 2 dorsal nerves of the clitoris. In vaginoplasty, the clitoris is reconstructed from a part of the glans penis inclusive of a part of the corona, the inner side of the prepuce is used to reconstruct the labia minora, and the penile shaft is inverted to line the vaginal cavity. MATERIAL AND METHODS:: A long-term sensitivity evaluation (performed by the Semmes-Weinstein monofilament and the Vibration tests) of 27 reconstructed phalli and 30 clitorises has been performed. RESULTS:: The average pressure and vibratory thresholds values for the phallus tip were, respectively, 11.1 g/mm and 3 mum. These values have been compared with the ones of the forearm (donor site). The average pressure and vibratory thresholds values for the clitoris were, respectively, 11.1 g/mm and 0.5 mum. These values have been compared with the ones of the normal male glans, taken from the literature.We also asked the examined patients if they experienced orgasm after surgery, during any sexual practice (ie, we considered only patients who attempted to have orgasm): all female-to-male and 85% of the male-to-female patients reported orgasm. CONCLUSION:: With our techniques, the reconstructed genitalia obtain tactile and erogenous sensitivity. To obtain a good tactile sensitivity in the reconstructed phallus, we believe that the coaptation of the cutaneous nerves of the flap with the ilioinguinalis nerve and with one of the 2 nerves of the clitoris is essential in obtaining this result. To obtain orgasm after phalloplasty, we believe that preservation of the clitoris beneath the reconstructed phallus and some preservation of the clitoris hood are essential. To obtain orgasm after a vaginoplasty, the reconstruction of the clitoris from the neurovascular pedicled glans flap is essential.

PMID: 17413887 [PubMed - as supplied by publisher]

 

[jasonschaffin]

Prefabrication of the free fibula osteocutaneous flap to create a functional human penis using a controlled fistula method.

* Chen HC,
* Gedebou TM,
* Yazar S,
* Tang YB.

Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung Medical College, Taipei, Taiwan.

Neophalloplasty remains one of the most challenging efforts in plastic and reconstructive surgery. The complex functional and aesthetic requirements are difficult to attain with consistency and safety. The current gold standard technique involves the use of a radial forearm tube-in-tube free flap, which also requires the placement of a stiffening prosthetic device for dual function. We report the safe use of the free fibula osteocutaneous flap to create a functional, cosmetically-acceptable penis utilizing the principles of prefabrication and controlled fistula method in one case of gender dysphoria.

PMID: 17479453 [PubMed - in process]

Neo-phalloplasty with re-innervated latissimus dorsi free flap: a functional study of a novel technique.

* Ranno R,
* Vesely J,
* Hyza P,
* Stupka I,
* Justan I,
* Dvorak Z,
* Monni N,
* Novak P,
* Ranno S.

Clinic of Plastic and Aesthetic Surgery, St. Anna University Hospital, Masaryk University, Brno, Czech Republic. [email protected]

Twenty two patients with gender dysphoria underwent neo-phalloplasties using a novel technique. Latissimus dorsi musculocutaneus re-innervated free flap was used to allow voluntary rigidity of the neo-penis. From the first 22 patients, 18 have obtained motoric function of reconstructed penis; the "paradox erection" was obtained. 14 patients came for examination after a follow-up period of mean 26.4 months. We evaluated the motility and shape changes of neo-phallus measuring its different size and dimension during relax and muscle contraction. The range of neo-phallus length in relaxed position was between 7 and 17 cm (mean 12.2 cm), its circumference in the same position had a range between 13 and 20 cm (mean 13.7 cm). All patients were able to contract the muscle with an average length reduction of 3.08 cm and an average circumference enlargement of 4 cm. In this study, the dimensions and motility were quantified demonstrating the neo-phallus function and size changes during sexual intercourse.

PMID: 17469438 [PubMed - in process]

A case of penile fracture with complete urethral disruption during sexual intercourse: a case report.

* Jagodic K,
* Erklavec M,
* Bizjak I,
* Poteko S,
* Korosec Jagodic H.

ABSTRACT: Penile fracture is a rare condition. Primarily it is a rupture of the corpus cavernosum that occurs when the penis is erect. The rupture can also affect the corpus spongiosum and the urethra. We report a case of a 37 year old man who presented with acute penile pain, penile swelling and the inability to pass urine after a blunt trauma during sexual intercourse. In emergency surgery we found bilateral partial rupture of the corpus cavernosum with complete urethral and corpus spongiosum disruption. In the one year follow up the patient presented with normal erectile and voiding function. Emergency surgical repair in penile fracture can preserve erectile and voiding function.

PMID: 17474981 [PubMed - as supplied by publisher]

 

[jasonschaffin]

Fecal pellet output does not always correlate with colonic transit in response to restraint stress and corticotropin-releasing factor in rats.

* Nakade Y,
* Mantyh C,
* Pappas TN,
* Takahashi T.

Department of Surgery, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA.

BACKGROUND: Fecal pellet output has been assessed as a colonic motor activity because of its simplicity. However, it remains unclear whether an acceleration of colonic transit correlates well with an increase in fecal pellet output. We examined the causal relationship between colonic transit and fecal pellet output stimulated by the central application of corticotropin-releasing factor (CRF) and restraint stress. METHODS: Immediately after intracisternal injection of CRF, (51)Cr was injected via a catheter positioned in the proximal colon. Ninety minutes after (51)Cr injection, the total number of excreted feces was counted, and then the rats were killed. The radioactivity of each colonic segment was evaluated, and the geometric center (GC) of the distribution of (51)Cr was calculated. For the restraint stress study, after administration of (51)Cr into the proximal colon, rats were submitted to wrapping restraint stress for 90 min. Then they were killed, and GC was calculated. RESULTS: Both restraint stress and CRF significantly accelerated colonic transit. There was a positive correlation observed between fecal pellet output and GC of colonic transit in response to restraint stress, but not CRF, when the number of excreted feces was more than three. In contrast, there was no significant correlation observed between the two in stress and CRF when the number of excreted feces was less than two. CONCLUSIONS: The acceleration of colonic transit in response to restraint stress and central administration of CRF does not always correlate with an increase in fecal pellet output.

PMID: 17464456 [PubMed - in process]

Anal canal anatomy showed by three-dimensional anorectal ultrasonography.

* Regadas FS,
* Murad-Regadas SM,
* Lima DM,
* Silva FR,
* Barreto RG,
* Souza MH,
* Filho FS.

Department of Surgery, Medical School of the Federal University of Ceara and Hospital Sao Carlos, Av Edilson Brasil Soares, 1892. Edson Queiroz, 60834-220, Fortaleza, Ceara, Brazil, [email protected].

BACKGROUND: Demonstrate precisely the anatomic configuration of the anal canal and the length and thickness of the anal sphincters using three-dimensional (3-D) anorectal ultra-sonography in both genders. METHODS: Twelve normal volunteer males and 14 females, with a mean age of 52.4 and 50.3 years, respectively, were prospectively enrolled in this study. All individuals from both groups were submitted to anorectal ultra-sonography. The anal canal was analyzed, measuring the length and thickness of the external anal sphincter (EAE), internal anal sphincter (IAS), puborectalis muscle (PR) and the gap (distance from the anterior EAS to the anorectal junction) in the midline longitudinal (ML) and transverse (MT) planes, and the results were compared between quadrants and genders. RESULTS: The distribution of sphincter muscles is asymmetric in both genders. The anterior upper anal canal is an extension of the rectal wall with all layers clearly identified. The anterior IAS is formed in the distal upper anal canal and is significantly shorter in female than in male in all quadrants. The anterior IAS length is shorter than the posterior and lateral in both genders. The anterior EAS length is significantly shorter (2.2 cm) and the gap is longer (1.2 cm) in female than in male (3.4 cm) (0.7 cm) (p < 0.05), respectively. The posterior and lateral EAS-PR is significant longer in males (3.6 cm) (3.9 cm) than in females (3.2 cm) (3.5 cm) (p < 0.05), respectively. The lateral EAS-PR is significant longer than the posterior part in both genders. The anterior IAS is significantly thicker in males (0.19 cm) than in females (0.12 cm) (p = 0.04). CONCLUSION: 3-D anal endosonography enabled measurement of the different anatomical structures of the anal canal and demonstrated its asymmetrical configuration. The shorter anterior EAS and IAS associated with a longer gap could justify the higher incidence of pelvic floor dysfunction in females, especially fecal incontinence and anorectocele with rectal intussusception.

PMID: 17479327 [PubMed - as supplied by publisher]

Anal Sphincter Laceration at Vaginal Delivery: Is This Event Coded Accurately?

* Brubaker L,
* Bradley CS,
* Handa VL,
* Richter HE,
* Visco A,
* Brown MB,
* Weber AM.

Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Illinois; Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa; Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, Maryland; Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama; Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan;. and National Institute of Child Health and Human Development, Bethesda, Maryland.

OBJECTIVE: To determine the error rate for discharge coding of anal sphincter laceration at vaginal delivery in a cohort of primiparous women. METHODS: As part of the Childbirth and Pelvic Symptoms study performed by the National Institutes of Health Pelvic Floor Disorders Network, we assessed the relationship between perineal lacerations and corresponding discharge codes in three groups of primiparous women: 393 women with anal sphincter laceration after vaginal delivery, 383 without anal sphincter laceration after vaginal delivery, and 107 after cesarean delivery before labor. Discharge codes for perineal lacerations were compared with data abstracted directly from the medical record shortly after delivery. Patterns of coding and coding error rates were described. RESULTS: The coding error rate varied by delivery group. Of 393 women with clinically recognized and repaired anal sphincter lacerations by medical record documentation, 92 (23.4%) were coded incorrectly (four as first- or second-degree perineal laceration and 88 with no code for perineal diagnosis or procedure). One (0.3%) of the 383 women who delivered vaginally without clinically reported anal sphincter laceration was coded with a sphincter tear. No women in the cesarean delivery group had a perineal laceration diagnostic code. Coding errors were not related to the number of deliveries at each clinical site. CONCLUSION: Discharge coding errors are common after delivery-associated anal sphincter laceration, with omitted codes representing the largest source of errors. Before diagnostic coding can be used as a quality measure of obstetric care, the clinical events of interest must be appropriately defined and accurately coded. LEVEL OF EVIDENCE: II.

PMID: 17470596 [PubMed - as supplied by publisher]

 

[jasonschaffin]

Fertilizability and chromosomal integrity of frozen-thawed Bryde's whale (Balaenoptera edeni) spermatozoa intracytoplasmically injected into mouse oocytes.

* Watanabe H,
* Tateno H,
* Kusakabe H,
* Matsuoka T,
* Kamiguchi Y,
* Fujise Y,
* Ishikawa H,
* Ohsumi S,
* Fukui Y.

Department of Animal Production Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.

Prior to attempting the in vitro production of embryos in the Bryde's whale (Balaenoputera edeni), we investigated whether spermatozoa can retain the capacity for oocyte activation and pronucleus formation as well as chromosomal integrity under cryopreservation by using intracytoplasmic sperm injection (ICSI) into mouse oocytes. Regardless of motility and viability, whale spermatozoa efficiently led to the activation of mouse oocytes (90.3-97.4%), and sperm nuclei successfully transformed into male pronucleus within activated ooplasm (87.2-93.6%). Chromosome analysis at the first cleavage metaphase (M) of the hybrid zygotes revealed that a majority (95.2%) of motile spermatozoa had the normal chromosome complement, while the percentage of chromosomal normality was significantly reduced to 63.5% in immotile spermatozoa and 50.0% in dead spermatozoa due to the increase in structural chromosome aberrations. This is the first report showing that motile Bryde's whale spermatozoa are competent to support embryonic development.

PMID: 17391541 [PubMed - indexed for MEDLINE]

Semen collection in rhinoceroses (Rhinoceros unicornis, Diceros bicornis, Ceratotherium simum) by electroejaculation with a uniquely designed probe.

* Roth TL,
* Stoops MA,
* Atkinson MW,
* Blumer ES,
* Campbell MK,
* Cameron KN,
* Citino SB,
* Maas AK.

Center for Conservation and Research of Endangered Wildlife, Cincinnati Zoo and Botanical Garden, 3400 Vine Street, Cincinnati, Ohio 45220, USA.

Electroejaculation in rhinoceroses has historically yielded inconsistent results, with the collection of high-quality, sperm-rich samples rare. The goal of this study was to develop a reliable method of electroejaculation in the rhinoceros by designing a rectal probe that appropriately fits the anatomy of this taxon and refining the procedure. A curved probe handle ending in an oblate, ellipsoid head was built using readily available supplies. A combination of rectal massage, penile massage, and electrical stimulation with a specially designed probe was employed in attempts to collect semen on 14 occasions from greater one-horned rhinoceroses (Rhinoceros unicornis; n = 4), black rhinoceroses (Diceros bicornis; n = 2) and a southern white rhinoceros (Ceratotherium simum; n = 1). During 13 of the 14 attempts, ejaculates were collected in multiple fractions. All but one of the ejaculates contained spermatozoa, and seven ejaculates contained good-quality fractions of semen (-60% sperm motility; > or =20 x 106 spermatozoa/ml) suitable for sperm banking and assisted reproduction procedures. Mean (+/-SEM) values for volume, pH, osmolality, and total sperm number for ejaculates containing good-quality fractions (98.2 +/-21.8 ml, 8.5+/-0.1, 290.4+/-6.7 mOsm, and 37.1+/-12.0 x 10(9), respectively) did not differ (P > 0.05) from those containing only poor-quality samples. Urine and/or erythrocyte contamination was not uncommon in fractions of both ejaculate types. Males producing good-quality samples ranged in age from 7 to 34 yr. None of the samples contained > or =75% morphologically normal spermatozoa. Electroejaculation with a uniquely designed probe consistently produced ejaculates in the rhinoceros. However, the production of high-quality samples continued to be challenging, occurring in only 50% of collection attempts. Regardless, the technology has progressed to a stage at which good-quality semen samples can be produced for sperm banking and assisted reproduction, and thereby can be integrated into intensive rhinoceros management strategies for the ultimate survival of this taxon.

PMID: 17312718 [PubMed - indexed for MEDLINE]

 

[jasonschaffin]

Assessment of penile vibratory stimulation as a management strategy in men with secondary retarded orgasm.

* Nelson CJ,
* Ahmed A,
* Valenzuela R,
* Parker M,
* Mulhall JP.

Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York 10022, USA. [email protected]

OBJECTIVES: To evaluate the effectiveness of penile vibratory stimulation for the management of retarded orgasm. Retarded orgasm, a condition characterized by difficulty achieving orgasm and ejaculation, is one of the most recalcitrant of the male sexual dysfunctions. Currently, no evidence-based treatments have been proven to ameliorate this condition. METHODS: Men who had a complete inability to achieve an orgasm during sexual relations in the previous 3 months were instructed in the use of penile vibratory stimulation. The men's responses were measured by self-report of orgasm function and using the orgasm and satisfaction domains of the International Index of Erectile Function. The responses were assessed at baseline (admission into the study) and at 3 and 6 months. RESULTS: A total of 36 men met the inclusion criteria, and 72% reported the restoration of orgasm. These responders reported that orgasm during sexual relations occurred 62% of the time. A statistically and clinically significant increase occurred in the orgasm and satisfaction domains of the International Index of Erectile Function between the baseline visit and the 3-month follow-up visit. These gains were sustained at 6 months. CONCLUSIONS: Penile vibratory stimulation is an effective treatment for retarded orgasm. Penile vibratory stimulation should be integrated into current cognitive-behavioral sex therapy techniques to achieve maximal effectiveness and satisfaction.

PMID: 17382163 [PubMed - indexed for MEDLINE]


[G-spot and female ejaculation: fiction or reality?]
[Article in Hebrew]

* Rabinerson D,
* Horowitz E.

Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva.

The G-spot is an ill-defined region, located on the anterior vaginal wall, in its upper outer third, suggested by Ernst Grafenberg, and commemorates the first letter of his name. This area is sensitive to tactile touch, which, when applied, is claimed to result in an intense female orgasm. The G-spot is thought to be the vaginal part that lies beneath the posterior part of the "female prostatic gland", which, when stimulated, results in female ejaculation during orgasm. G-spot and female ejaculation have been studied intensively during the last 50 years and there is scientific (anatomical and biochemical) evidence for their existence. However, this evidence has been challenged, and the debate regarding the existence of the G-spot and female ejaculation as true clinical entities is still ongoing.

PMID: 17352286 [PubMed - indexed for MEDLINE]

 

[jasonschaffin]

Characteristics of ejaculated rat semen after lesion of scrotal nerves.

* Garcia LI,
* Soto-Cid A,
* Carrillo P,
* Toledo R,
* Hernandez ME,
* Manzo J.

Instituto de Neuroetologia, Universidad Veracruzana, Apartado Postal 566, Xalapa, Ver., 91000, Mexico.

The scrotum, representing the pouch surrounding the testes and their associated structures, plays a significant role in maintaining the gonad at a temperature lower than that of the body. Although thermoregulation of the testes has been ascribed as a main function of the scrotum, here we found that mechanical stimulation of the scrotum is important during mating to facilitate the appropriate expulsion of semen during ejaculation. Previously we showed that the scrotal skin area is innervated by two nerve branches, the proximal (Psb) and distal (Dsb) scrotal branches which supply the proximal or distal half of the scrotum, respectively. The sensory field of each nerve is testosterone-dependent. The decreased androgen levels following castration reduce the sensitive area to mechanical stimuli that can be restored following exogenous administration of the hormone. Here, we tested the effect of scrotal nerve transection on sexual parameters of experienced male rats. Data show that lesion of PSb or DSb alone or combined did not affect the execution of sexual behavior. However, these lesions significantly reduced the proportion of males that expelled semen during ejaculation, with that semen showing a reduced quantity of sperm. Thus, scrotal nerves are important in reproduction not for the appropriate display of sexual behavior, but for the expulsion of a normal quantity of semen and number of sperm during ejaculation. Our suggestion is that scrotal afferents trigger spinal reflexes to activate autonomic efferents supplying the male reproductive tract for the control of seminal emission.

PMID: 17343882 [PubMed - in process]


Involvement of nitric oxide in cocaine-induced erections and ejaculations after paradoxical sleep deprivation.

* Andersen ML,
* Perry JC,
* Antunes IB,
* Tufik S.

Department of Psychobiology - Universidade Federal de Sao Paulo, Escola Paulista de Medicina (UNIFESP/EPM), R. Napoleao de Barros, 925, V. Clementino 04024-002, Sao Paulo, SP, Brazil.

OBJECTIVES: As nitric oxide (NO) is involved in penile erectile (PE) function and also influences the sleep-wake cycle, we speculated that NO could play a role in PE and ejaculation of paradonical sleep deprivation (PSD) rats. METHODS: Animals were pretreated with N(G)-nitro-l-arginine methyl ester (l-NAME, ip) and l-arginine (ip and icv) prior to saline or cocaine injection. RESULTS: Cocaine-induced PE in 90% of PSD rats, 60% of which ejaculated. l-NAME reduced the frequency of erection, but had no effect in the proportion of PSD-cocaine-injected rats displaying this response. l-NAME had no effect in saline groups. l-Arginine in PSD-saline rats reduced the proportion of animals displaying PE at the highest dose and reduced the frequency of PE at all doses in both saline and cocaine groups. The icv administration of l-arginine reduced PE only in PSD-cocaine rats. Results indicate that common to both drugs, whether it was NO synthase (NOS) inhibitor or NO precursor, was their capacity to strongly reduce PE frequency in cocaine-treated rats. Moreover, l-arginine (ip) played a relevant inhibitory role in the erection displayed by PSD rats. CONCLUSIONS: Our findings suggest that the stimulating effects of PSD associated or not with cocaine on erection can be modified by alterations in the NO system.

PMID: 17276569 [PubMed - in process]


Application of 2 vibrators salvages ejaculatory failures to 1 vibrator during penile vibratory stimulation in men with spinal cord injuries.

* Brackett NL,
* Kafetsoulis A,
* Ibrahim E,
* Aballa TC,
* Lynne CM.

Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA.

PURPOSE: Penile vibratory stimulation is the treatment of first choice for anejaculation in men with spinal cord injury. Nonresponders to penile vibratory stimulation are usually referred for electroejaculation or surgical sperm retrieval. Compared to penile vibratory stimulation these methods are invasive and usually yield lower total motile sperm, potentially limiting options for assisted reproductive technologies. To avoid these less than ideal options a simple method to salvage penile vibratory stimulation failures would be of benefit to spinal cord injured patients. We investigated the recovery rate when 2 vibrators were used to salvage ejaculatory failures to 1 vibrator in men with spinal cord injury. MATERIALS AND METHODS: A retrospective chart review was performed in 297 spinal cord injured men who underwent a total of 965 trials of penile vibratory stimulation at our center between 1991 and 2006. Only trials with high amplitude vibrators were examined. All men underwent 2 or more penile vibratory stimulation trials using 1 vibrator applied to the dorsum or frenulum of the glans penis. Men failing to ejaculate with 1 vibrator received 1 or more trials in which the glans penis was then sandwiched between 2 vibrators. RESULTS: Of all men 49% and 57% of those whose level of injury was T10 or above responded to penile vibratory stimulation with 1 vibrator. Of failures with 1 vibrator 22% responded to penile vibratory stimulation with 2 vibrators. CONCLUSIONS: Application of 2 vibrators salvaged ejaculatory failures to 1 vibrator during penile vibratory stimulation procedures in men with spinal cord injury. This simple penile vibratory stimulation sandwich method is recommended before referring patients for electroejaculation or surgical sperm retrieval.

PMID: 17222653 [PubMed - indexed for MEDLINE]

 

[jasonschaffin]

The gag reflex and fellatio.

* GIOSCIA N.

PMID: 14783215 [PubMed - indexed for MEDLINE]

Delusion of pregnancy in a male homosexual with an abdominal cancer.

* ARONSON GJ.

PMID: 14944984 [PubMed - indexed for MEDLINE]