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Common Problems ON Cycle: What To Do?

Force of Green said:
I've been hearing and reading a lot of good things as far as using I3C as part of PCT as it is a compound used to correct hormonal abnormalities. It is employed to decrease bad estrogens and allow beneficial estrogens.

I'll be using a natural approach (well, OTC) in my next PCT and it will be based off of I3C and trans-resveratrol.
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Keep us posted bro!
 
My cholesterol came back high HDL 62 LDL 123. Alanine Amino Tra high 58. White blood cell count 3.6 low. Eosinophils 6.2 high.

I have no idea what Eosinophils are. Is the alanine level refering to alanine levels, like beta alanine? I've been taking it.

All I know is that cycle support is going to become a staple after seeing my cholesterol profile. NAC as well.
 
Mach .78 said:
My cholesterol came back high HDL 62 LDL 123. Alanine Amino Tra high 58. White blood cell count 3.6 low. Eosinophils 6.2 high.

I have no idea what Eosinophils are. Is the alanine level refering to alanine levels, like beta alanine? I've been taking it.

All I know is that cycle support is going to become a staple after seeing my cholesterol profile. NAC as well.
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I'm usually not a fan of sustained release formulas, however, I've read good things about Jarrow Formulas NAC Sustain. It's good, patented, dual release NAC.
 
I3C- Helps channel the good and bad estrogen. I believe there are some studies somewhere with breast cancer. Can't also aid in liver cleansing.

Niacin- Increases HDL, high doses for an extended period of time can be hepatoxic.

SAMe- Great liver protectant. Potential anti-estrogenic properties.

I forget the doses of Niacin and later on I will search around or see if I can get Dinoiii in here for these 3.
 
From what I see on my bloodwork, I shouldn't take niacin until my liver enzymes come down. Everybody in my family is saying they are elevated because of all the stuff I take, the liver has to process it. I think they may have something here. If so, I would venture to say others here probably have elevated liver enzymes as well. Thanks for the suggestions and the article.
 
Why no post for back/calf pumps? I know it's fairly straight forward to fix, but writing it up may be helpful, too.
 
If I go to the doc and say man check out these puffy nipps, can the doc prescribe anything for that or will he just laugh and say Sorry son??
 
payner said:
If I go to the doc and say man check out these puffy nipps, can the doc prescribe anything for that or will he just laugh and say Sorry son??
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Oh he'll just laugh and say Sorry son ...but only after he tells you to drop your pants and right before he tells you to turn to the left and cough. :)
 
MANimal said:
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In conclusion, Melatonin is a very underrated support supplement and makes one heck of synergist of SERMS like nolva taken for post cycle therapy.
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Melatonin has been shown to increase prolactin in human studies, so i would be suspect that melatonin would help with recovery, in humans.
 
melatonin

Well this thread was posted over 3 months ago, but any how, I've never heard of melatonin being used for pct.
 
payner said:
Well this thread was posted over 3 months ago, but any how, I've never heard of melatonin being used for pct.
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It doesn't have a role in PCT I don't think. The complimentary effect it has with tamoxifen is related to breast cancer. See: NOTE

More importantly you can continue to take melatonin during PCT without it negatively effecting recovery.

"Taken together, these data suggest that long-term melatonin administration does not alter the secretory patterns of reproductive hormones in normal men." i.e. LH, FSH, testosterone - Long-term melatonin administration does not alter pituitary-gonadal hormone secretion in normal men, Rafael Luboshitzky et al, Human Reproduction, Vol. 15, No. 1, 60-65, January 2000

"Melatonin treatment did not cause any significant change in basal or post-stimulation LH and FSH levels either in men or in post-menopausal women." - Effect of melatonin on the basal and stimulated gonadotropin levels in normal men and postmenopausal women, H Fideleff, Journal of Clinical Endocrinology & Metabolism, Vol 42, 1014-1017​

I wouldn't worry about melatonin increasing prolactin.

"The results suggest that melatonin has no acute modulatory effect on the secretion of these two sleep-related hormones." i.e Growth Hormone & Prolactin - A model for the study of the acute effects of melatonin in man, RJ Strassman, Journal of Clinical Endocrinology & Metabolism, Vol 65, 847-852​



NOTE:
Source: Melatonin augments the sensitivity of MCF-7 human breast cancer cells to tamoxifen in vitro, ST Wilson, J. Clin. Endocrinol. Metab., Aug 1992; 75: 669 - 670.

ABBREVIATIONS:

Melatonin (MLT)
Tamoxifen (TAM)
Estradiol (E2)
Estrogen (E)​

DISCUSSION:

The rationale for this experiment was based on previous studies demonstrating that MLT: 1) inhibits estrogen-stimulated MCF-7 cell growth, 2) alters ER levels in MCF-7 cells blocks the E2 rescue of TAM inhibited MCF-7 cells. Therefore, because of MLT’s modulatory effect on the estrogen-response pathway in this cell line, we tested the hypothesis that short-term MLT pretreatment increases the sensitivity of MCF-7 cells to the subsequent long-term inhibitory effects of either TAM or MLT itself.

As expected, TAM inhibited cell growth in the vehicle pretreated cells in a dose-response manner. However, the TAM dose-response curve was shifted to the left when cells were pre-exposed to MLT. Comparison of IC50 values for vehicle and MLT pretreated cells indicate that TAM is approximately 100-fold more potent when MCF-7 cells are preexposed to MLT rather than the vehicle for 24 hrs. These results suggest that MLT somehow “sensitizes” the cells such that TAM is a more effective inhibitor of cell proliferation not only at its therapeutic dose (371 ug/mL) but at much lower doses which were ineffective.

Pretreatment of MCF-7 cells with MLT has a modest effect on augmenting their sensitivity to the inhibitory effects of a subsequent re-exposure to MLT. Comparison of the IC50 values for vehicle and MLT pretreated cells indicates that MLT is only about 8-fold more potent following pre-exposure of the cells to itself.

In the control experiment, a 24 hr pulse of MLT, in the absence of further MLT or TAM treatment had no effect on cell proliferation. These data indicate that the increased effectiveness of TAM in MLT pre-exposed cells is not due to an additive effect of growth inhibition during the MLT pre-exposure period.

Tamoxifen, because of its low toxicity and relative effectiveness in the treatment of metastatic ER-positive breast cancer now represents the endocrine treatment of choice in postmenopausal patients. However, in spite of its many advantages, some patients with ER-positive cancer respond for only a short time or not at all. The findings presented here may form the basis for a novel and effective approach to treating some TAM-failed patients by sensitizing their breast cancer cells to TAM with MLT.​
 
I ve read sone of your posts. You are knowledgeable. I ve heard that Chlorodrol 50 is mild with little to no side effects. It is my first cycle on anything ever. Should I take milk thistle with it? I am on day 4.
Thank You

34 year old Male
triathlete
 
Cubate said:
I ve read sone of your posts. You are knowledgeable. I ve heard that Chlorodrol 50 is mild with little to no side effects. It is my first cycle on anything ever. Should I take milk thistle with it? I am on day 4.
Thank You

34 year old Male
triathlete
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Glad you bumped this thread, very informative.

I, personally, would take milk thistle with any oral... methylated or not. I'm not sure what Chlorodrol 50 is though, what is/are the ingredient(s)?
 
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