Coleus Forskolii
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Enigma76
Active member
Random987 said:
The ratios are still alittle up in the air right now, Matt has to decide whats more cost effective.
But it'll most likely be 3x per day dosing, with the amount of TTA being between 2-3g per day if you dose 3x (depending on the ratios Matt wants to use). We tried to find a number that would work for most people; those who are sensitive to TTA could dose 2x per day, for instance, and still receive the proper amount of the other ingredients. Those who can bump to 3x per day will just receive more of everything.
The ratios of the other compounds will be very good as well. This product will probably cost a tad bit more, but with 3x per day dosing you'll get a great amount of each compound.
Also, I am very excited about the synergy this product will have with Power Jolt and Lean Support, especially Power Jolt.
Enigma76
Active member
Reggin said:
Ephedrine doesnt sit too well with me, and forskolin does the same job without the CNS stimulation. This product will be a great one to run alongside the C2, but the ephedrine might be alittle redundant.
You could try doing c2/eph/TTA for 2 weeks and then switch over to Omega Ripped (tentative name) for 2 weeks if you wanted to use ephedrine, and going back and forth to help the whole beta-receptor-downregulation-problem associated with ephedrine.
I really suggest using some kind of caffeine related product concurrently with Omega Ripped as it will be silly to not take advantage of the synergy.
Reggin
Member
Enigma76 said:
Ephedrine exerts most of its fat loss effects through appetite suppression, not necessarily through cAMP/HSL stimulation. And although I'm not 100% sure, there may be an additive effect when combining the ephedrine with the forskolin in inducing lypolysis.
Also, what kind of synergy exists with the caffeine?
BodyWizard
Registered User
okay, well that's great & all - but when can we start throwing money at you for it???custom said:
bigblank69
Board Supporter
CAPPED!!!!!
Enigma76
Active member
App suppression is quite a part of ephedrine, but dont underestimate its metabolic effects.Reggin said:
The synergy of caffeine lies in its phosphodiesterase inhibiting properties. This enzyme is responsible for the breakdown of circulating cAMP...so not only is cAMP raised via forskolin, but it also remains elevated due to less of the enzyme that removes it.
Plus, for those who are prone to lethargy with TTA, the caffeine will help.
Enigma76
Active member
Also, I would like to point out the fact that EGCG has been shown to inhibit COMT, which breaks down norepinephrine. So here, with this stack + caffeine, you will get raised levels of cAMP from both direct and indirect mechanisms (forskolin raises it directly, caffeine indirectly raises it thru inhibition of the PDE enzyme that breaks down cAMP) and raised levels of NE from COMT inhibition due to EGCG.
Wait till the writeup, I put alot of this in there.
Wait till the writeup, I put alot of this in there.
BodyWizard
Registered User
:afro:custom said:I like your style!
:dance:custom said:
Random987
New member
Just watch the upper limits on the forskolin because of the lower GI issues. Over 100mg of forskolin and you may have to place a warning to stay close to the restroom after taking.
This may be why:
Signalling mechanism coupled to 5-hydroxytryptamine4 receptor-mediated facilitation of fast synaptic transmission in the guinea-pig ileum myenteric plexus.
Galligan JJ, Pan H, Messori E.
Department of Pharmacology and Toxicology and The Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA. [email protected]
5-hydroxytryptamine (HT)4 receptor agonists stimulate gastrointestinal motility partly by facilitating acetylcholine release from myenteric neurones. However, the signalling mechanisms that couple 5-HT4 receptor activation to increased transmitter release in the myenteric plexus are unknown. We used conventional intracellular electrophysiological methods to record fast excitatory postsynaptic potentials (fEPSPs) from neurones in the guinea-pig ileum myenteric plexus preparation. The substituted benzamide, renzapride, acted at 5-HT4 receptors to facilitate fEPSPs. This response was mimicked by forskolin, an activator of adenylate cyclase. Facilitation of fEPSPs by renzapride and forskolin was not blocked by treating tissues with pertussis toxin (PTX) (2 h, 2 microg mL-1). Facilitation of fEPSPs caused by renzapride was blocked by the non-selective protein kinase inhibitors, staurosporine (1 micromol L-1) and H-8 (30 micromol L-1) and by the selective protein kinase A (PKA) inhibitor, H-89 (10 micromol L-1). These data indicate that 5-HT4 receptors act via a PTX-resistant mechanism to activate PKA. Protein kinase A activation leads to an increase in transmitter release from myenteric nerve terminals and a facilitation of fast excitatory synaptic transmission.
This may be why:
Signalling mechanism coupled to 5-hydroxytryptamine4 receptor-mediated facilitation of fast synaptic transmission in the guinea-pig ileum myenteric plexus.
Galligan JJ, Pan H, Messori E.
Department of Pharmacology and Toxicology and The Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA. [email protected]
5-hydroxytryptamine (HT)4 receptor agonists stimulate gastrointestinal motility partly by facilitating acetylcholine release from myenteric neurones. However, the signalling mechanisms that couple 5-HT4 receptor activation to increased transmitter release in the myenteric plexus are unknown. We used conventional intracellular electrophysiological methods to record fast excitatory postsynaptic potentials (fEPSPs) from neurones in the guinea-pig ileum myenteric plexus preparation. The substituted benzamide, renzapride, acted at 5-HT4 receptors to facilitate fEPSPs. This response was mimicked by forskolin, an activator of adenylate cyclase. Facilitation of fEPSPs by renzapride and forskolin was not blocked by treating tissues with pertussis toxin (PTX) (2 h, 2 microg mL-1). Facilitation of fEPSPs caused by renzapride was blocked by the non-selective protein kinase inhibitors, staurosporine (1 micromol L-1) and H-8 (30 micromol L-1) and by the selective protein kinase A (PKA) inhibitor, H-89 (10 micromol L-1). These data indicate that 5-HT4 receptors act via a PTX-resistant mechanism to activate PKA. Protein kinase A activation leads to an increase in transmitter release from myenteric nerve terminals and a facilitation of fast excitatory synaptic transmission.
Enigma76 said:
Enigma76
Active member
Random987 said:
Ya I saw that over on avant today...apparently some spoke of developing an eventual tolerance?
Maximal recommended dosing will not go above 100mg forskolin per day. Plus, it will be divided up 3x per day, preferably once before bed, so the higher end of the dosing scheme might be okay due to extended periods of time in between doses.
canadian champ
Active member
sounds like this is gonna be a great product. If you are still looking for a name, how about Lypolysis or Melt.
cc
cc
BodyWizard
Registered User
time to throw money yet?
Ubiquitous
Registered User
son of a bitch.. same with me.. lol
custom
Well-known member
unitas27 said:
I think for the beta we are going to try 800/800/125 of TTA:GT:Forskohlii.
We were toying aroudn with the idea of upping the TTA to 1 gram and lowering the Green Tea to 600, but that made things a bit expensive and at 800mg, Green Tea starts to do some really, really cool things.
BodyWizard
Registered User
get out your catcher's mitt, bro - the coin is flyin!
:woohoo:
:woohoo:
Enigma76
Active member
custom said:
Matt, when I get some time I want to send you an updated version of the writeup. Hopefully this weekend.
BTW guys, its 800mg of GTE @50% EGCG, so 400mg EGCG, and 125mg @ 20% forskolin, so 25mg of forskolin (and of course 800mg of TTA). That is per serving (dunno the # caps per serving) and can be taken 2-3 times per day.
The low end of dosing (2x per day) yields 1.6g TTA, 800mg EGCG and 50mg of forskolin. This would be for those who are sensitive to the sides of TTA, and still have enough of the actives to be effective (most forskolin studies cite 50mg as the effective dose for fat loss).
3x per day dosing will yield 2.4g TTA, 1200mg EGCG and 75mg forskolin.
Combining this with caffeine will provide for some very nice synergies.
DAdams91982
Board Sponsor
Enigma76 said:
YUM YUM.. .How long???
Adams
Enigma76
Active member
And we still need to come up with a name for this...:twisted:
I'm pretty happy with this ratio, as you get the appropriate amount of each compound necessary for fat loss, and you have the ability to assess tolerances and switch dosing protocols around to avoid side effects, and yet the minimum dosing has enough of the actives to be effective. No more underdosed fat loss products!
Plus guys, this can easily be stacked very well with PowerJolt and Lean Support, adn the synergy with PowerJolt should be damn nice.
I'd probably recommend a 2x per day dosing initially to assess tolerance to forskolin (with the lower GI issues) and TTA, and then bump up to 3x per day, with one before bed. If you know how you react to forskolin/TTA, then by all means jump into 3x per day dosing.
I'll leave this one out there...The amount of GTE in this should provide for some nice appetite suppression, but know that for me at least (I assume many others) its very easy to out-eat TTA's effects, and GTE doesnt provide as much appetite suppression as I would like...although I've never dosed GTE this high before. Hopefully the large amount of GTE will help curb the appetite while being a great antioxidant.
I'm really looking foward to trying this myself :twisted:.
I'm pretty happy with this ratio, as you get the appropriate amount of each compound necessary for fat loss, and you have the ability to assess tolerances and switch dosing protocols around to avoid side effects, and yet the minimum dosing has enough of the actives to be effective. No more underdosed fat loss products!
Plus guys, this can easily be stacked very well with PowerJolt and Lean Support, adn the synergy with PowerJolt should be damn nice.
I'd probably recommend a 2x per day dosing initially to assess tolerance to forskolin (with the lower GI issues) and TTA, and then bump up to 3x per day, with one before bed. If you know how you react to forskolin/TTA, then by all means jump into 3x per day dosing.
I'll leave this one out there...The amount of GTE in this should provide for some nice appetite suppression, but know that for me at least (I assume many others) its very easy to out-eat TTA's effects, and GTE doesnt provide as much appetite suppression as I would like...although I've never dosed GTE this high before. Hopefully the large amount of GTE will help curb the appetite while being a great antioxidant.
I'm really looking foward to trying this myself :twisted:.
sean taylor
West Coast Highland Athlete
Matt, I defintely want a bottle but not to run a log on or anything.
Let me know when they come in so I can pick one up sir.
Let me know when they come in so I can pick one up sir.
The Godfather
Member
I have never noticed/heard of GTE causing appetite suppression. Any chance sof a quick overview of mechanism or a reference/article on the matter?Enigma76 said:
Thanks
DAdams91982
Board Sponsor
I'll be near by in 2-3 weeks custom... so expect a drop by!!! :twisted:
Adams
Adams
diamonddave
Board Supporter
The Godfather said:
I'll bet it doesn't suppress mine. But, it looks excellent from the fat loss side. It will take some juggling (because of the TTA) but I think I'm going to stack it with Lipidfx. This is to raise TTA intake and get some appettite suppression.
So far the only combo that has given me TOTAL control of my appettite was a stack of Ectotropin-6 & Lipidfx. Effective but too expensive to consider long term. Anyway...
I can't wait.
dd
sean taylor
West Coast Highland Athlete
custom said:
And find out when you will be carrying RETAIN.
sean taylor
West Coast Highland Athlete
bump
Enigma76
Active member
Ceaze said:
I've also seen this, but I'm unsure as to how it impacts absorption of TTA...GTE supposedly inhibits pancreatic and gastric lipases to a degree, and thus limits the amount of dietary fat broken down and absorbed...however, I'm nto sure if TTA is "broken down" per se by lipase prior to entering the bloodstream...I also dont know the mechanism for absorption of fats from the gut.
WhutEvr
Member
I purchased TTA/Forslean and GTE from CNW last week and made up some "000" caps.
50mg Forslean
400mg GTE
600mg TTA
Got a good warmth taking 2 caps for the first 4 days; upped it to 3 caps yesterday.
Geez, it's 65 in the office - have a fan running on my desk and I'm sweating like crazy. May have to wear shorts tomorrow.
Hasn't effected my appetite though.
50mg Forslean
400mg GTE
600mg TTA
Got a good warmth taking 2 caps for the first 4 days; upped it to 3 caps yesterday.
Geez, it's 65 in the office - have a fan running on my desk and I'm sweating like crazy. May have to wear shorts tomorrow.
Hasn't effected my appetite though.
mrmoose63
Member
I doubt it will, I started taking 3cAMP x 2(forsoklin, green tea, bacopa, cissus), 8 Melting Point, and 4 Sesamin per day as my cutting stack... I'll be taking 2-3 weeks off and then ordering Bulk TTA and capped forsolkin from MattWhutEvr said:
... if anything this stack has increased my appetite but that could also be due to dietary changes I've made recently... but damn it does heat you up! I literally pour buckets of sweat during cardio now ~3lbs different before and after to give you an idea of the water I'm drippin-Moose