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What are your thoughts on Cardarine? Some people say it is carcinogenic.
GSK isn't going to say one way or the other because they don't have the data and the drug didn't make it to human trials. This review cites the reasons why they didn't go further than animal models, "Despite these promising early results, the further investigation and development of GW501516 was discontinued after observations in animal studies of its association with the rapid induction of cancers in several organs (liver, stomach, tongue, skin, bladder, ovaries, womb and testes)."People have been taking this stuff for years and I cant recall any published links to reports of people getting Cancer?
Also WADA got Glaxo Smith Kline who developed it, to release a statement because of sportsmen/women taking it and all GSK would say that it hadn't been researched at high doses and over a lengthy time in humans. NOWHERE in the statement did GSK say it 'Could or Would' cause Cancer in the joint WADA press release. Now if it DID don't you think they might have said so, baring in mind the purpose was to put Sportsmen and Women off from taking it?
Make of that what you will.
yep. Everything has a cost, but there seems to be many more options out there and too many what ifs with this one.Idk,Cardarine seems a little too good to be true, that the product even have cancer connected to it is enough for me to stay away
Are you sure they're still looking at that? I'm not seeing anything recent on them studying it. It also looks like it's available from several suppliers for research (actual research purposes).In development Glaxo has a compound called GW0742 same benefit without showing cancer so who knows how long before we can get our hands on it.
Good catch rumor was a few months away as a research only use wink wink. But to get our actual hands on it could be awhile. Also sr9009 is marketed as being similar to gw50156 but has a short half life making it prohibitively expensive. So if this requires multiple doses forget it.Are you sure they're still looking at that? I'm not seeing anything recent on them studying it. It also looks like it's available from several suppliers for research (actual research purposes).
SR-9001 is the new REV-ERB agonist on the block, which I saw claims of a “proposed” 4 hr half life via oral supplementation. Interesting one there!Good catch rumor was a few months away as a research only use wink wink. But to get our actual hands on it could be awhile. Also sr9009 is marketed as being similar to gw50156 but has a short half life making it prohibitively expensive. So if this requires multiple doses forget it.
The valuable research on GW is so scarce that its almost irrelevant. For human use, all "research" is anecdotal. The only way this could have happened is people taking a chance on a relatively unresearched compound.Speaking of other PPAR agonists, anyone tried GW-0742? It’s touted as being Cardarine 2.0.
I was searching for some reviews elsewhere for a bit and didn’t have much luck. People seem to be quite leary of it as it has less “research” available than Cardarine.
I came very close to buying some..
Ever drank soda?Idk,Cardarine seems a little too good to be true, that the product even have cancer connected to it is enough for me to stay away
Oh, I completely agreeThe valuable research on GW is so scarce that its almost irrelevant. For human use, all "research" is anecdotal. The only way this could have happened is people taking a chance on a relatively unresearched compound.
Are you implying drinking soda has a direct cause in cancer? What data shows that?Ever drank soda?
You're messing with cell growth and differentiation pathways. If (and it is an if) cardarine causes cancer in human, you'll be too far along by the time symptoms show up. More than likely a lot of these compounds won't cause cancer, but god help you if you develop a tumor while taking them.The way I figure is if I get cancer from Cardarine in say 10 years the will have a sarm for that haha.
As I pointed out, Cardarine has been used for years and there is NO evidence it causes Cancer in humans. There is some research evidence it actually reduces the likelihood of Colon Cancer in humans. Also the EU has severe strict laws on carcinogens being sold for human consumption...Cardarine is legal.You're messing with cell growth and differentiation pathways. If (and it is an if) cardarine causes cancer in human, you'll be too far along by the time symptoms show up. More than likely a lot of these compounds won't cause cancer, but god help you if you develop a tumor while taking them.
Im implying they've been connected.Are you implying drinking soda has a direct cause in cancer? What data shows that?
When did I say it causes cancer? I said it would make a bad situation worse if you developed a tumor from something else while using it.As I pointed out, Cardarine has been used for years and there is NO evidence it causes Cancer in humans. There is some research evidence it actually reduces the likelihood of Colon Cancer in humans. Also the EU has severe strict laws on carcinogens being sold for human consumption...Cardarine is legal.
I'm more concerned about pollution and air quality along with UVA damage than bloody Cardarine as they DO cause cancer.
God help you if you don't look whilst crossing the road as well.
Further a Phase IV human trial was carried out in Australia 2008 and NO adverse effects were noted.
Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity - PubMed
GW501516 increased the hepatic removal of VLDL particles, which might have resulted from decreased apoC-III concentration. GW501516 increased apoA-II production, resulting in an increased concentration of LpA-I:A-II particles. This study elucidates the mechanism of action of this PPAR-δ agonist...www.ncbi.nlm.nih.gov
Wait... I’m fairly sure Cardarine is not “legal” to be sold as a dietary supplement. Isn’t it a drug that was abandoned by GSK and Ligand Pharmaceuticals? I’m pretty sure anyone selling it is selling it “for research purposes only,” and not “for human consumption.” Or at least they shouldn’t be. It’s grey market at best really TBH. This is a weak argument on your part.As I pointed out, Cardarine has been used for years and there is NO evidence it causes Cancer in humans. There is some research evidence it actually reduces the likelihood of Colon Cancer in humans. Also the EU has severe strict laws on carcinogens being sold for human consumption...Cardarine is legal.
I'm more concerned about pollution and air quality along with UVA damage than bloody Cardarine as they DO cause cancer.
God help you if you don't look whilst crossing the road as well.
Further a Phase IV human trial was carried out in Australia 2008 and NO adverse effects were noted.
Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity - PubMed
GW501516 increased the hepatic removal of VLDL particles, which might have resulted from decreased apoC-III concentration. GW501516 increased apoA-II production, resulting in an increased concentration of LpA-I:A-II particles. This study elucidates the mechanism of action of this PPAR-δ agonist...www.ncbi.nlm.nih.gov
Anyone who tells someone to "just Google it" has a fundamental misunderstanding of what a burden of proof is, or who it rests with...Im implying they've been connected.
Its one straightforwardly worded google search away.
I'm not concerned with presenting a case. I didn't intend on this conversation becoming about sodas. My point was that if something being loosely to associated with cancer scares someone, their life is going to be profoundly limited by that. Whether someone is compelled to look into what i say is of absolutely zero concern to me.Anyone who tells someone to "just Google it" has a fundamental misunderstanding of what a burden of proof is, or who it rests with...
I get what you're saying and also don't want to derail the conversation into soda, especially since I call it pop. However, there is a difference between a nuclear receptor agonist involved in direct modulation of physiological processes vs sodas can cause obesity and obesity may lead to an environment conducive to cancer.I'm not concerned with presenting a case. I didn't intend on this conversation becoming about sodas. My point was that if something being loosely to associated with cancer scares someone, their life is going to be profoundly limited by that. Whether someone is compelled to look into what i say is of absolutely zero concern to me.
And I'm telling you that it's ignorant or disingenuous to compare Cardarine to soda in relation to cancer growth. You can have your pick which of the two you'd prefer to be considered...I'm not concerned with presenting a case. I didn't intend on this conversation becoming about sodas. My point was that if something being loosely to associated with cancer scares someone, their life is going to be profoundly limited by that. Whether someone is compelled to look into what i say is of absolutely zero concern to me.
You have made up the 12 weeks as I said no such thing and I wouldn't suggest to anybody to run Cardarine either for 12 weeks.When did I say it causes cancer? I said it would make a bad situation worse if you developed a tumor from something else while using it.
As for that trial, they gave a dose of 2.5 mg for 6 weeks and you seem to be suggesting 10 mg for 12 weeks. Also, you can't say that there were no adverse effects because it wasn't measured. Adverse events was not an endpoint of this trial https://clinicaltrials.gov/ct2/show/NCT00841217
My mistake on the first part as I confused you with patrick25 as you both have the same avatar. And yet again, where did I say it did, but that's not how science works. You have to actually perform a human trial that looks at use and test for cancer, including follow-up data. I can say unicorns also don't cause cancer because there is no evidence of it.You have made up the 12 weeks as I said no such thing and I wouldn't suggest to anybody to run Cardarine either for 12 weeks.
The fact is there is NO evidence it causes Cancer in humans.
Personally I would use Sr9009 over Cardarine but its each to their own and Cardarine has its place until research says otherwise.
No one is suggesting it CAUSES cancer in humans, "only" that it may increase the growth/development of existing cancers. Futhermore, what human evidence do you want? There are no human studies more than a few weeks in duration; of course short-term studies aren't going to show cancer growth. It'd have to be an incredibly potent carcinogen if it did...You have made up the 12 weeks as I said no such thing and I wouldn't suggest to anybody to run Cardarine either for 12 weeks.
The fact is there is NO evidence it causes Cancer in humans.
Personally I would use Sr9009 over Cardarine but its each to their own and Cardarine has its place until research says otherwise.
That sounds an awful lot like an opinion.And I'm telling you that it's ignorant or disingenuous to compare Cardarine to soda in relation to cancer growth. You can have your pick which of the two you'd prefer to be considered...
Haha, good times! I don't know if that thread linked it, but here's a good write-up on the reserach on Cadarine that discusses a ton of studies:Well, here we go again with yet another Cardarine/cancer tussle
The best one I have seen involved @Old Witch, and @muscleupcrohn. It’s an entertaining and informative read as both members presented their point of view in greater detail than we usually see on this topic.
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands do not potentiate gr - AnabolicMinds.com
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands do not potentiate gr Here’s the article, for anyone still convinced cardarine is a carcinogen despite every shred of evidence to the contrary. https://academic.oup.com/carcin/article/28/12/2641/2476288anabolicminds.com
Shrooms before pharmaceuticals . Honestly, I’ve been wanting to try these. Also, lions mane seems awesomeI’ve tried cardarine a couple times and honestly never noticed much from it. I have had substantially better results with Cordyceps 10:1 when it comes to endurance. Just my two cents
ThisWell, here we go again with yet another Cardarine/cancer tussle
The best one I have seen involved @Old Witch, and @muscleupcrohn. It’s an entertaining and informative read as both members presented their point of view in greater detail than we usually see on this topic.
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands do not potentiate gr - AnabolicMinds.com
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands do not potentiate gr Here’s the article, for anyone still convinced cardarine is a carcinogen despite every shred of evidence to the contrary. https://academic.oup.com/carcin/article/28/12/2641/2476288anabolicminds.com
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