yohimbine aids in a lot of stuff :
Yohimbine blocks the pre- and post-synaptic alpha-2 adrenoceptors. Blockade of post-synaptic alpha-2 adrenoceptors leads to minor corpora cavernosa smooth muscle relaxation. In fact the majority of adrenoceptors in the corpora cavernosa are alpha-1. Blockade of pre-synaptic alpha-2 adrenoceptors leads to increased release of neurotransmitters in the Central Nervous System and in the corpora cavernosa penis such as nitric oxide, noradrenaline and dopamine. Whether Nitric Oxide released in the corpora cavernosa has a relaxing effect, noradrenaline has a much powerful constricting effect by stimulating the unblocked alpha-1 adrenoceptors. Concomitant use of an alpha-1 blocking agent will prevent constriction caused by the increased adrenergic stimulation.[6]
Yohimbine has been shown to be effective in the reversal of sexual satiety and exhaustion in male rats.[7] Yohimbine has also been shown to increase the volume of ejaculated semen in dogs, with the effect lasting at least five hours after administration.[8] Yohimbine has been shown to be effective in the treatment of orgasmic dysfunction in men.[9]
[edit]Fat loss
According to one study, oral yohimbine supplementation may actuate significant fat loss in athletes.[10] Numerous bodybuilding supplement companies sell formulations of yohimbine for transdermal delivery to effect a local reduction of adipose tissue, although the experimental evidence for its efficiency is limited.[11][12]
Yohimbine has significant side effects, such as anxiety reactions. According to the Mayo Clinic, yohimbine can be dangerous if used in excessive amounts.[21]
Higher doses of oral yohimbine may create numerous side effects, such as rapid heart rate, high blood pressure, overstimulation, insomnia and/or sleeplessness. Some effects in rare cases were panic attacks, hallucinations, headaches, dizziness, and skin flushing.[22]
More serious adverse effects may include seizures and renal failure. Yohimbine should not be consumed by anyone with liver, kidney, heart disease, or a psychological disorder.[22]
The therapeutic index of yohimbine is quite low; the range between an effective dose and a dangerous dose is very narrow.[22] This may also lead to precipitation of panic disorder type reactions.
Yohimbine in combination with modafinil is frequently associated with nausea, dangerous acute rapid heart beat, and acute increased blood pressure. Yohimbine exhibits some degree of MAOI activity while modafinil has been shown to increase levels of various monamines, and therefore could result in severe risk of dangerous side effects.
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