i think you would be best off to source the proper amount of your desired amount of each hormone and take the dose that works.. I don't believe LG pays any attention to proper dosing, mostly due to their use of absorption enhancers. they like to claim these really high numbers for bypassing the first pass of the liver. however there is very little if any human studies showing that these cyclodextrins and such work with the given hormones they espouse them to. again, hormones are fat soluble so i would take fish oil with your efficacious sized doses of said PHs.