Beta-Androstenetriol Transdermal ?

Toff

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o they below cam ein via email, what can anyone say abvout this? Originally looking to 11-keto for fatloss and recomp but would this be as good?

Product Description
Invictus
Beta-Androstenetriol Transdermal
The main ingredient in Invictus is beta androstenetriol (Androstene-3 beta-7 beta-17 beta-triol) — a powerful cortisol suppressant and immune boosting agent — in a revolutionary and patent-pending transdermal delivery system, designed to boost bio-availability to levels that would simply not be possible via oral administration. In other words it delivers more of the active ingredient b-AET into your bloodstream. Invictus represents the next step in commercial physique enhancing formulas, and the results it generates will need to be seen to be believed!
Iron Legion Invictus Key Benefits
Increased Fat Loss
Control Cortisol Levels
Maintain Muscle Mass
Reduce Inflammation
Improved Immune Response
Zero Conversion to HPTA Suppressive Hormones
Can be Used During PCT
Can be Stacked with Fat Burner of Choice
Androstene-3 beta-7 beta-17 beta-triol (b-AET) represents a key naturally occurring 7-hydroxy dehydroepiandrosterone (DHEA) metabolite. Produced from the adrenal gland, DHEA and its sulfate are the major circulating adrenal steroids in humans. Studies on Androstenetriol show its ability to strongly counteract cortisol and boost lymphocyte activity.
Cortisol is one of the body’s most abundant and important endogenous steroids. Listing in detail the expansive list of cortisol’s many functions in our body is a nearly impossible task, to summarize we can say that cortisol’s role in the human body is to break down bodily tissue and nutrients for the purpose of energy provision (to be catabolic), to act as an immunosuppressive, and to regulate blood sugar. In a nutshell, cortisol is responsible for inhibiting many of the processes that we as fitness enthusiasts want to start, and for starting many of the processes that we want to inhibit.
CONTAINS: Isopropanol, propylene glycol, benzyl alcohol, cis-9-octadecanoic acid, Beta Androstenetriol (3b, 7b, 17b) 3-Acetate, N-n-butyl-benzoyl-2-sulphimide, stearyl methacrylate, nerolidol, glycerin, hypromellose.
DIRECTIONS:
Use the dropper to apply 1-2 mL topically. Ideal application sites include the chest, shoulders, and neck.
WARNINGS:
For external use only! Harmful if swallowed. Do not apply to the face or eyes. Not intended for use by women and persons under 21 years of age! End user assumes all risks stemming from the use, handling and storage of this product.
 
BigKrabbe

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I believe this was used in lean extreme at one point if it still isn't. I would go with 11-keto in terms of effectiveness, unless you are looking to avoid any possible suppression. In my opinion you will get more bang for your buck with 11-keto.
 
Dma378

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Been using it for 2 weeks and it has already made a noticeable affect on fat loss and hardening.
 

Daycrawler

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I believe this was used in lean extreme at one point if it still isn't. I would go with 11-keto in terms of effectiveness, unless you are looking to avoid any possible suppression. In my opinion you will get more bang for your buck with 11-keto.
This is topical. b-AET is very effective and does not require a PCT contrasted with 11-KT.

OP, I've been running SNS Reduce XT + Invictus for 4 weeks now and it's been great. Half dosing each.

I'd def recommend either and Invictus is a solid product.
 

BANE44

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Invictus is good stuff. I seen a bunch of good reviews on it, tried it and love it. Only problem is i need to order more.
 
IronLegion

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better or worse than 11-kt? Any studies?
There are a TON of studies on b-AET.

b-AET and 11-keto are quite different. 11-keto is quite androgenic and can cause suppression...it's an active steroid. 11-keto does not impact cortisol throughout the body, but only in the target tissues (muscle, liver, etc).

b-AET lowers cortisol systemically and offers a myriad of benefits associated with lowering the impacts of stress on the body. b-AET has extensive and wide variety of research backing it!

Here's links to just a few studies I have off the top of my head:

1. Antiglucocorticoid function of androstenetriol.
http://www.ncbi.nlm.nih.gov/pubmed/9264155

2. Auci DL, Ahlem CN, Kennedy MR, Page TM, Reading CL, Frincke JM. A Potential Role for 5-Androstene-3[beta],7[beta],17[beta]-triol in Obesity and Metabolic Syndrome. Obesity.
http://www.nature.com/oby/journal/vaop/ncurrent/abs/oby2010204a.html

3. Lu M, Patsouris D, Li P, et al. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. American Journal of Physiology – Endocrinology and Metabolism 2010;298(5):E1036-E48.
http://ajpendo.physiology.org/content/298/5/E1036.full

4. Malik AK, Khaldoyanidi S, Auci DL, et al. 5-androstene-3,7,17-triol (b-AET) Slows Thermal Injury Induced Osteopenia in Mice: Relation to Aging and Osteoporosis. PLoS ONE;5(10):e13566.
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013566

5. Marcu AC, Paccione KE, Barbee RW, et al. Androstenetriol Immunomodulation Improves Survival in a Severe Trauma Hemorrhage Shock Model. The Journal of Trauma 2007;63(3):662-9.

6. Pharmacology and immune modulating properties of 5-androstene-3β,7β,17β-triol, a DHEA metabolite in the human metabolome.
http://www.ncbi.nlm.nih.gov/pubmed/21570467

7. Phase I and Phase II clinical trials of androst-5-ene-3β,7β,17β-triol
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102572/

8. 5-Androstene-3β,7β,17β-triol (β-AET) Slows Thermal Injury Induced Osteopenia in Mice: Relation to Aging and Osteoporosis
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013566

Another writeup on b-AET from primordial performance (archive)
Anti-inflammatory Benefits of Androstenetriol (5-androstene-3 beta-7 beta-17 beta-triol, beta AET)

DECEMBER 31, 2010 LEAVE A COMMENT

Androstene-3 beta-7 beta-17 beta-triol (AET) represents a key naturally occurring 7-hydroxy dehydroepiandrosterone (DHEA) metabolite. Produced from the adrenal gland, DHEA and its sulfate are the major circulating adrenal steroids in humans. Serum levels peak in young adults, but then steadily decline with age, falling over 80% by age 70. DHEA serves as a precursor of male and female sex hormones. (1, 3, 5, 6)

DHEA demonstrates a plethora of anti-aging properties in rodents, including anti-inflammatory, anti-obesity, anti-diabetic, immune enhancing activities, and opposes certain activities of endogenous glucocorticoids (GC). As the literature grew, DHEA became widely used as an anti-aging, anti-stress dietary supplement. Despite these well-documented activities in animal models, DHEA supplementation in humans has yielded inconclusive results and the value of DHEA replacement in humans is controversial. Such widely different outcomes in rodents and humans have been referred to as ‘the DHEA conundrum’. Moreover, the potential therapeutic use of DHEA is limited by its side effects due to its conversion to sex hormones.

One possibility to explain these discrepancies is that a metabolite(s) of DHEA, rather than DHEA itself, may be necessary for its full action in human physiology. DHEA undergoes extensive conversion and derivatization to multiple products by phase 1 reactions involving the cytochrome P450 system, and studies have shown that these phase 1 products can be more potent than parental DHEA. Phase 1 reactions frequently decline in elderly subjects, and since such subjects have been the major participants in human DHEA treatment studies, it is possible that biologically active metabolites of DHEA were not produced in adequate amounts in previous human studies. It is also possible that qualitative changes in DHEA metabolism between rodents and humans will account for these differences.

DHEA oxidation via the action of the enzyme CYP7B leads to the 7-hydroxy derivatives of C-19 steroids, which are collectively present in low nanomolar concentrations in human circulation and are not readily metabolized to potent androgens or estrogens. Many of the functions initially attributed to DHEA from observations in rodents are now thought to be properties of these oxygenated metabolites, particularly AET.

Molecular Structure of Androstenetriol


AET possesses some of the anti-inflammatory and GC-opposing activities that have been attributed to DHEA, but with greater apparent potency. Studies with AET demonstrate it markedly up regulates host immune response, prevents immune suppression, modulates inflammation and improves survival after lethal infections by pathogens and lethal radiation. (1, 3, 5, 6)

AET has been shown to be protective against traumatic shock. Traumatic shock activates the hypothalamic-pituitary-adrenal axis (HPA) to mediate a cascade of defensive mechanisms that often include overwhelming inflammatory response and immunosuppression, which may lead to multiple organ failure. In a relevant traumatic hemorrhagic shock rodent model that applies to both combat and civilian sectors, AET provided a significant protective effect and improved survival. In a murine thermal injury model that includes glucocorticoid-induced osteopenia, AET significantly preserved bone mineral content, restored whole body bone mineral content and bone growth, suggesting reversal of GC-mediated adverse effects.

Since AET is a naturally occurring compound there is no patent protection leaving the door wide open for AET analogue research. Harbor BioSciences, Inc. – http://www.harborbiosciences.com/ (Public, OTC:HRBR – http://www.google.com/finance?q=OTC:HRBR ) is exploring a synthetic derivative of AET for the treatment of diseases with underlying chronic inflammation. HRBR has developed 17alpha-Ethynyl-5-androsten-3beta, 7beta, 17beta-triol (HE3286), a synthetic derivative AET. (1, 2, 4, 7)

Within the past two years, animal model studies of HE3286 successfully demonstrate the treatment of lung inflammation without immune suppression, the reduction of established disease of rheumatoid arthritis, and both glucose-lowering and cholesterol-lowering effects. Harbor BioSciences most ambitious project to date is their recently released data regarding that plasma levels of AET positively correlate with BMI in healthy men and women.(1) These observations suggest a compensatory role for AET in preventing the development of metabolic syndrome and obesity. The AET structural core may provide the basis for novel pharmaceuticals to treat this disease, HE3286. Stay tuned.


1. Auci DL, Ahlem CN, Kennedy MR, Page TM, Reading CL, Frincke JM. A Potential Role for 5-Androstene-3[beta],7[beta],17[beta]-triol in Obesity and Metabolic Syndrome. Obesity. http://www.nature.com/oby/journal/vaop/ncurrent/abs/oby2010204a.html

2. Conrad D, Wang A, Pieters R, et al. HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression. Journal of Inflammation 2010;7(1):52. http://www.journal-inflammation.com/content/7/1/52

3. Loria RM. Antiglucocorticoid function of androstenetriol. Psychoneuroendocrinology 1997;22 Suppl 1:S103-8.

4. Lu M, Patsouris D, Li P, et al. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. American Journal of Physiology – Endocrinology And Metabolism 2010;298(5):E1036-E48. http://ajpendo.physiology.org/content/298/5/E1036.full

5. Malik AK, Khaldoyanidi S, Auci DL, et al. 5-androstene-3?,7?,17?-triol (?-AET) Slows Thermal Injury Induced Osteopenia in Mice: Relation to Aging and Osteoporosis. PLoS ONE;5(10):e13566. http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013566

6. Marcu AC, Paccione KE, Barbee RW, et al. Androstenetriol Immunomodulation Improves Survival in a Severe Trauma Hemorrhage Shock Model. The Journal of Trauma 2007;63(3):662-9.

7. Offner H, Firestein GS, Boyle DL, et al. An Orally Bioavailable Synthetic Analog of an Active Dehydroepiandrosterone Metabolite Reduces Established Disease in Rodent Models of Rheumatoid Arthritis. Journal of Pharmacology and Experimental Therapeutics 2009;329(3):1100-9. http://jpet.aspetjournals.org/content/329/3/1100.full

8. Stiles AR, McDonald JG, Bauman DR, Russell DW. CYP7B1: One Cytochrome P450, Two Human Genetic Diseases, and Multiple Physiological Functions. Journal of Biological Chemistry 2009;284(42):28485-9.
There's quite a bit of information on this compound, and it's extensive benefits!
 
IronLegion

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it's rare to find something that offers such broad spectrum of benefits
 

Toff

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so would you say its like 7-keto, fatloss and cortisol reduction without the andro addtion that 11 has?

Curious where this fits in
 
IronLegion

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so would you say its like 7-keto, fatloss and cortisol reduction without the andro addtion that 11 has?

Curious where this fits in
7-keto get's it's cortisol reduction properties from it's conversion to b-AET, but that's a low conversion rate. 7-keto is more thermogenic and less cortisol reduction.

11-keto is a different type of product. Again, it has no impact on cortisol levels in the body, it impacts cortisol via 11hsb1 (only certain tissue, muscle/liver/fat cells). It does very little to offer any health benefits.

7-keto and b-AET would be a great stack!

there have been some guys who stacked invictus with 11-keto with some solid results. It's a very versatile product
 

alvin1

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Is that better than arimistane for cortisol control?
 
delsolrob

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Is that better than arimistane for cortisol control?
I would venture to say, significantly!

there are tons of studies for b-AET and it's benefits on cortisol control, and benefits for improving immune response, weight loss/obesity, reducing inflammation, correcting blood sugar, etc...I have not seen any studies for arimistane for these things (not to say they don't exist, but I've never seen them in the research that I've done).
 
delsolrob

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Piledahlaren

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Just want to give Iron-Legion rep a BIG thank you for all the help with my order! excellent customer service!
Will have 3 bottles of Invictus to enjoy thru the next year : ) (but will prob order more ;D )
 

kisaj

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Just ordered some, that is a great sale. I wish Virtus was in stock to try that as well.
 
IronLegion

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Awesome, thank you for your order!

We're aiming to have virtus around the 22nd. Be sure you sign up for our mail list to ensure you get in on the re-intro sale on it ;)
 

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would love to try, but unfortunately you guys have like the most ridiculous international shipping prices i've ever seen :(
 
IronLegion

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would love to try, but unfortunately you guys have like the most ridiculous international shipping prices i've ever seen :(
Pm me your info : address , email address, and what you're looking to order..will see what i can do
 
IronLegion

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would love to try, but unfortunately you guys have like the most ridiculous international shipping prices i've ever seen :(

ahhhh, there was a mistake in the backend of the international shipping module translating ounces to pounds...corrected this, now the shipping options should seem a bit more reasonable :)

Sorry for the hassle!
 
bighulksmash

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I just ran 2 bottles of this and I noticed quite a bit of different things happening.
1. Increased pain tolerance
2. Thinning effect especially on belly
3. Mild strength increase
4. Better sleep
5. Crazy dreams
6. Way better sexual performance
7. Way better cardiovascular performance
8. Softer skin
9. More mentally focused
10. Lower back pain seems to be non existing after 3 weeks of use .

Thats just 10 theres much more . Lets just hope theres still stock left to buy !!!

Also** I'll be running 2 more bottles.
 

kisaj

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Well, I am excited to see how this works out. I plan to run a bottle and see the result, then decide on purchasing more.
 
Piledahlaren

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Well, I am excited to see how this works out. I plan to run a bottle and see the result, then decide on purchasing more.
If this carrier is just as good or better as the product I used in the past.. then you will LOVE it : )
 

Daycrawler

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Well, I am excited to see how this works out. I plan to run a bottle and see the result, then decide on purchasing more.

No regrets here :D

 

dynamo

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How does it compare to 11-keto? My guess is that 11-keto would be far more effective.
 

dynamo

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Well, 11-kt is also a PH.....
For cortisol control purposes, there's such mild unwanted sides and suppression that I don't really feel like it poses much of an issue.
 
DWeaver

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So is it best to take Invictus at 1ml first thing in the am or should I split it up 1/2 am, 1/2 pm?
 
bighulksmash

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I split mine . But thats me , others may have diff opinions. Just seems to work better .
 
delsolrob

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Split doses seem to be best. and, I would not recommend taking 1ml at a time. if you are going to just use it once a day, just use .5ml :)
 
DWeaver

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Split doses seem to be best. and, I would not recommend taking 1ml at a time. if you are going to just use it once a day, just use .5ml :)
I've been using 1ml in the am for 3 weeks now with no problems. Why is that a issue?
 
DWeaver

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Also I'm not sure if it's me or the Invictus but I've cut my stim use in half since I've started it. Some days I go almost all day and won't even realize I haven't taken my ECY yet.
 
Alex281

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Just jumped on a deal for this bad boy,planning a 2 month run with virtus
 
delsolrob

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I've been using 1ml in the am for 3 weeks now with no problems. Why is that a issue?
ma70 also did this. But, dropping cortisol too low at one time can be counterproductive. One school of thought is that you want to moderate cortisol during peak times...in the AM and in the PM. It is likely more efficient to split the doses because of this. if you apply in the AM, it won't do much for the evening cortisol spike.
 

BANE44

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.5ml in the morning and .5 ml before bed worked great for me. Great stuff!
 
IronLegion

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For cortisol control purposes, there's such mild unwanted sides and suppression that I don't really feel like it poses much of an issue.
11-keto does not suppress or control cortisol, it merely modulates it in target tissue. 11-keto would not offer most of the benefits Invictus does on immune system, inflammation, blood sugar, etc.
 

pryncess

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how much b-AET per dose? does it say on the bottle? just curious & can't find pic of back of bottle. thx!
 

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