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Between meals! The studies indicate that consuming ~ 3 grams between meals (I want to say about (1.5-2hrs+ after and before each meal I.e lunch at 1pm, 3g leucine at 3pm, dinner at 6pm, etc.) I believe Dr. Layne Norton conducted the studies. There's a certain protein synthesis threshold and an exposure time between doses to get an effect. For instance, sipping on a whey shake all day won't give you constantly elevated protein synthesis. By "pulsing" leucine (fast acting) between your whole food meals you appear to get a lot of benefit
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meals spaced 4-6 hours apart with 3-5g Leucine between.
