From my experience established gyno is impossible to get rid of entirely without surgery, however our product will reduce the risk factors associated with gyno. Reducing estrogen alone is not the most efficient way to combat gyno, whereas reducing prolactin in conjunction with estrogen is a more effective way. It all depends on the situation. It is best used preemptively. Ideally you would take it to reduce the risk factors of gyno, but you could also take it once the problem exists to reduce the problem substantially.