My Mom has Dementia and is 89 yrs old. The Dementia has not been too bad until the last 6 months where her short term memory is really getting bad.
What do you think could help my Mom's brain? ty...
She is on some things from her dr...for anti stroke anti seizure. I am planning an appoinment to if her dr can prescribe anything (but i doubt they will). This has been a slow decline for many years and been known and treated by her drs (neurolgist, psych and gp).Her doctor doesn't have her on anything?
What source would u recommend. I personally have tried Pure Bulk's powder and gotten only a little result (but its cheap compared to others).Lions Mane as well. 1.5 to 3g a day. Been studied to reverse dementia in rats.
The nootropics depot brand is quality.What source would u recommend. I personally have tried Pure Bulk's powder and gotten only a little result (but its cheap compared to others).
What source would u recommend. I personally have tried Pure Bulk's powder and gotten only a little result (but its cheap compared to others).
She is on some things from her dr...for anti stroke anti seizure. I am planning an appoinment to if her dr can prescribe anything (but i doubt they will). This has been a slow decline for many years and been known and treated by her drs (neurolgist, psych and gp).
I missed this one. This would negate most nootropics in my opinion. A lot of times though, elderly get diagnosed with dementia and it isn't dementia at all. It is actually delirium. There are a lot of things that can contribute to neurological deficits in the elderly. They can look like dementia but if you can pinpoint the underlying cause, and correct it, there function will come back. But it isn't always easy to pinpoint.She is on some things from her dr...for anti stroke anti seizure. I am planning an appoinment to if her dr can prescribe anything (but i doubt they will). This has been a slow decline for many years and been known and treated by her drs (neurolgist, psych and gp).
any drug interactions to watch for with agmatine?First thing - get her bloods and look for anomalies. Take a list of her medications. Avoid anti-acetycholinergic drugs (benedryl for instance).
Agmatine is incredibly helpful in the elderly. It has been shown to reverse dementia and alzheimers in mouse models, is backed by peripheral studies lonking arginine depletion to alzheimers and dementia, protects against TIA and stroke damage, etc.
Chances are with someone that age, they are probably on blood thinners. If they are, I would be very, very cautious about giving them anything herbal.
Lots of stuff out there shows promise, very little delivers any true world benefit. I have had my grandmother on Agmatine and it has helped in numerous ways, but it isn't going to stop time.
There are some that I know of - mostly positive. I am more than happy to look into any drugs if either you or the OP want to PM me a list or discuss my experience. I am no doctor but I have had a lot of experience with my own grandmother.any drug interactions to watch for with agmatine?
Gonna get a list for you. ty Bro...There are some that I know of - mostly positive. I am more than happy to look into any drugs if either you or the OP want to PM me a list or discuss my experience. I am no doctor but I have had a lot of experience with my own grandmother.
The reason I got my grandmother on it was because she was using opioids for chronic pain. The agmatine reduces tolerance to opioids and has helped us to reduce her dose from 50 mcg/hr of fentanyl and 25 mg/oxycodone per day to just 5 mg of oxycodone per day. There were other factors, but ir certainly helped.
It is also good for pain, depression and anxiety itself...although very minor.
It gies well with opioids, SSRIs, anxiety meds, etc. because of these effects.
In theory it could have a transient blood pressure lowering effect.
In other words, a lot of the interactions will warrant a lower dose of the drugs being needed and should not be dangerous.
The CYP450 interactions for agmatine are almost non-existent it seems as well, so it isn't like a grapefruit type effect, it won't effect the pharmacology of the drugs directly in most cases.
My grandmother is on warfarin and we have had no issues with the blood thinners, etc.
I may be forgetting something, but if you have a drug in question and I can help I will.
Cool. Hope I can help. Like I said, I am not a doctor, just a disclaimer. But I will share what I know and can back up.Gonna get a list for you. ty Bro...
you re a good man, thank you!!!Cool. Hope I can help. Like I said, I am not a doctor, just a disclaimer. But I will share what I know and can back up.
Great post - and yeah, the gradual decline does point to dementia. But gradual can be dependant on what exactly they are observing. Sometimes families see memory issues and slight confusion, that slowly turns into something more profound, like a sudden hallucination or loss of executive function, and they will describe it as gradual when really the newest item is more accute.IIRC he said this has been progressing for years I.e. not delirium
Agmatine has nearly no bioavailability and an exceedingly transient half-life. It is actually labeled as “non-drug like” in most pharmacology sim databases.
Looking at anticholinergic drugs is a great idea as many elderly have extensive lists of medications which can impact cognitive reserve.
Short of cancer pain, there is no indication for chronic opioids.
This won’t be a popular opinion but there is literally nothing that can reverse dementia *once it is clinically apparent.* Monoclonal Ab’s Have been developed which can eradicate amyloid and tau in the brain and do not impact progression. This is because the organic mechanical damage to the neuron and neuronal circuits has already passed threshold for recovery. The trick is for earlier screening interventions.
As far as neuronal / symptomatic salvage, acetylcholine esterase inhibitors May prolong activity of daily living but again will not impact progression and most will have limited objective benefit.
*Early* cognitive impairment is best served by minimizing vascular risk factors (especially blood pressure and diabetes), low carbohydrate diets, and caloric restriction for those with metabolic syndrome. Supplement wise, Niagen, galantamine, DHA, possibly Ach sources (CDP choline, alpha GPC).
Source: I am a neurologist.
doctors have definitely cut back on prescribing opioids...in their defense many were concerned with quality of life issues from chronic pain...there are very few effective alternatives available for those who suffer from serious chronic pain that interferes with living a normal active life.Also, glad to hear your views on opioids. I share this view...acute, end of life or possibly surgical treatment, but definately no chronic application. Wish more doctors saw this sooner.
Sorry to bump this, but it doesn’t look like I can pm you. I’m starting medical school this year, and am looking at incorporating some of the nootropic advice from your old posts on here/your blog/other forums.IIRC he said this has been progressing for years I.e. not delirium
Agmatine has nearly no bioavailability and an exceedingly transient half-life. It is actually labeled as “non-drug like” in most pharmacology sim databases.
Looking at anticholinergic drugs is a great idea as many elderly have extensive lists of medications which can impact cognitive reserve.
Short of cancer pain, there is no indication for chronic opioids.
This won’t be a popular opinion but there is literally nothing that can reverse dementia *once it is clinically apparent.* Monoclonal Ab’s Have been developed which can eradicate amyloid and tau in the brain and do not impact progression. This is because the organic mechanical damage to the neuron and neuronal circuits has already passed threshold for recovery. The trick is for earlier screening interventions.
As far as neuronal / symptomatic salvage, acetylcholine esterase inhibitors May prolong activity of daily living but again will not impact progression and most will have limited objective benefit.
*Early* cognitive impairment is best served by minimizing vascular risk factors (especially blood pressure and diabetes), low carbohydrate diets, and caloric restriction for those with metabolic syndrome. Supplement wise, Niagen, galantamine, DHA, possibly Ach sources (CDP choline, alpha GPC).
Source: I am a neurologist.
I did see that, and believe you said Cdp-choline does not share the same byproducts/effects.a lot of my opinions have changed, yes. I now recommend against alpha GPC. I’ve written about it recently.
Do nootropics work for dementia at all? I thought there was no cure for that disease whatsoever.
a lot of my opinions have changed, yes. I now recommend against alpha GPC. I’ve written about it recently.
I just realized who you are. I used to read your old blog. Do you have a new blog? Always loved the information you brought to this forum and others.
I haven't seen him @Irishobrien post on here in a long time. I wasn't aware that he had a blog; could you pm me a link to it? I always liked him and would like to get in touch with him.
Yeah he seems to pop in here sporadically. If it’s who I’m thinking of, I’m pretty sure he had the blog High Tower Pharmacology or something. Many years ago, I guess some of his work was plagiarized, so he made it private or something. I think that’s why that guy was asking if there’s a new one.
I never knew he had a blog, but I always enjoyed him posting here. He had stopped awhile back when there was an argument between him and someone else. I missed the argument, but I knew that's why he stopped posting and I really hate it that he did because he was a good contributor.
I am pretty sure that is Neuron. High Tower Pharmacology was the blog. People like him and No Hype used to be great posters. They predated Mr. Cooper in great informative posts. Obviously Mr. Cooper became a high caliber poster as well. They used to all have fantastic discussions, along with other names that elude me at the moment, on a supplement science sun forum on another site I will not name out of respect for AM that I loved.
Yea I am not 100% sure if it is him. Just figure I’d take a shot.I'm familiar with all of those guys and still keep in touch with a lot of the posters from back then outside the forums.
You had quoted @Irishobrien , so that was who I was talking about. If he had a blog, I didn't know about it and he's someone I would have liked to have stayed in touch with but he stopped posting on here awhile ago.
I am pretty sure that is Neuron. High Tower Pharmacology was the blog. People like him and No Hype used to be great posters. They predated Mr. Cooper in great informative posts. Obviously Mr. Cooper became a high caliber poster as well. They used to all have fantastic discussions, along with other names that elude me at the moment, on a supplement science sun forum on another site I will not name out of respect for AM that I loved.
Appreciate it man![]()
I wonder what happened to Mr. Cooper and what he is currently involved with?I am pretty sure that is Neuron. High Tower Pharmacology was the blog. People like him and No Hype used to be great posters. They predated Mr. Cooper in great informative posts. Obviously Mr. Cooper became a high caliber poster as well. They used to all have fantastic discussions, along with other names that elude me at the moment, on a supplement science sun forum on another site I will not name out of respect for AM that I loved.