Added in Berberine hcl yesterday. Ate 40 grams of quick carbs and took a Berberine an hour pre workout, the pumps and vascularity was nuts. I could feel my chest filling out with every set. Incline bench pressed 275x3, an all time best for me.
Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine - PubMed
Berberine impairs muscle metabolism by two novel mechanisms. It impairs mitochonidrial function stimulating the expression of atrogin-1 without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulated protein degradation but also suppressed...
www.ncbi.nlm.nih.gov