Effect of Eurycoma longifolia extract on androgen biosynthesis
Norhaniza, A; Ramli, A; Hamid AAH; Johari, MS
Department of Biochemistry, University of Malaya; Kuala Lumpur, Malaysia
13th Seminar on Natural Products; Forest Research Institute Malaysia, 5-6 August 1997
Abstract:
Eurycoma longifolia extract which is believed to have aphrodisiac properties was tested in mice and human testicular
homogenates. The claimed effect was observed through the ability of the extract to enhance the elevation of the androgen
level in the homogenates. In vitro analysis using capillary gas chromatography on rat testicular homogenates showed an
increase in androgen level. The levels of testosterone and its metabolism were seen to be significantly higher with the
presence of Eurycoma longifolia extract. In vivo studies was carried out by treating male mice through intraperitonial
injection. The effect of Eurycoma longifolia extract on the serum testosterone level was examined by radioimmunoassay. Our
observation showed that the serum testosterone level in treated mice was significantly higher than the untreated mice.
Results obtained suggest that Eurycoma longifolia extract has the ability to increase the biosynthesis of androgen. The
observed effect could provide the possible explanation of the claimed aphrodisiac properties of the plant.
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Forest Research Institute Malaysia