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Would a transdermal arachidonic acid product be possible, with a more localised carrier approach/delivery system?

Thoughts for this idea...
1)It could make ARA more appealing to people who try to reduce overall or area specific inflammation.
2)A localised carrier ARA could be very useful in bringing up lagging body parts.
This is interesting. Didn’t Evomuse do it with I think it was Top Muscle. Had some good reviews but never really heard too much about it after the initial batch.
 
I thought the same but I looked it up and found some articles that have done it successfully, at what cost who knows.
If it worked that would probably be great for belly fat loss. From what I have read pharm grade tesamorelin is amazing for it. Just stupid expensive , like the cost of a car a year unless you have aids
 
This is interesting. Didn’t Evomuse do it with I think it was Top Muscle. Had some good reviews but never really heard too much about it after the initial batch.
ARA is one of the best, if not the best, natty anabolics, but as with everything that works, it has drawbacks and side effects. Having it in a localised form would remove a fair amount of those
 
I'm a big fan of your products, Apex. Here are my 2 suggestions:

1) N-Courmaroyldopamine & N-Caffeoyldopamine. These were in USPLabs Compound 20 and my body responded well to them. Have not found a supplement that carries these two. I think the closest was og Alphamine. That is, unless your Flashpoint already does---which I've used and had great results. Also responding well to your Ursa Major, which I'm currently using.

2) a transdermal mucuna pruriens, that is, if mucuna would benefit from a TD application. The original EndoSurge had two diff % mucuna's and that shtuff was amazing. Found a spot that sold 99% pure mucuna but they no longer carry it. Mucuna has so many wonderful benefits and I'm wondering if possible with TD, it'd be just as great.
 
I thought the same but I looked it up and found some articles that have done it successfully, at what cost who knows.

Like @nostrum420 stated ... I would be interested in reading the articles .... But what is (almost??) Universally the case ... Is that a company will advertise such a product, and hype it up until everyone gets excited.
They will then make lots of sales ... Until everyone realizes that it never worked to begin with.

Then the hype dies down, with the company much wealthier.

:-(
 
I'm a big fan of your products, Apex. Here are my 2 suggestions:

1) N-Courmaroyldopamine & N-Caffeoyldopamine. These were in USPLabs Compound 20 and my body responded well to them. Have not found a supplement that carries these two. I think the closest was og Alphamine. That is, unless your Flashpoint already does---which I've used and had great results. Also responding well to your Ursa Major, which I'm currently using.

2) a transdermal mucuna pruriens, that is, if mucuna would benefit from a TD application. The original EndoSurge had two diff % mucuna's and that shtuff was amazing. Found a spot that sold 99% pure mucuna but they no longer carry it. Mucuna has so many wonderful benefits and I'm wondering if possible with TD, it'd be just as great.
Compound 20 was so fucking sick
 
Anyone else getting slightly melancholy in this thread thinking back to the days of yore hunting for compounds in vida 😔

Ok not to derail the purpose of this thread

Corydyceps extract. I think I saw for cordyceptin has a molecular weight of 251
 
I thought the same but I looked it up and found some articles that have done it successfully, at what cost who knows.
I don't think any of these can be done successfully. Definition of successful is what I'm questioning. Even if you get it into solution for TD application, something like tesamorelin has like 5% oral bioavailability, injectable is usually close to 100%. If they could get it into TD and make it work the bioavailability is still going to be really low and the amount needed to get a good dose would probably be outrageous. Plus I don't think nos dips his toes in peptides. If RC stuff is on the table then slu-pp and dada could definitely go transdermal. I was really hoping the healing peps would work as TD back when everyone was trying to put it out there. No dice tho. It would be amazing to just rub BPC 157 and TB 500 on my injuries and call it a day
 
A new rectal pre-workout!
Wonder if DNP can be applied topically or some other uncouplers for fat burning
 
Today

You​

ursolic acid uncoupling

Copilot​

Ursolic acid has been shown to induce mitochondrial uncoupling, which can have several beneficial effects on cellular health1. Here are some key points:

  • Mitochondrial Uncoupling: Ursolic acid can increase mitochondrial reactive oxygen species (ROS) production, leading to mitochondrial uncoupling1. This process helps to reduce oxidative stress and protect cells from damage1.
  • Glutathione Redox Cycling: Ursolic acid enhances glutathione redox cycling, which is an important antioxidant defense mechanism1.
  • Protection Against Oxidant Injury: Studies have shown that ursolic acid can protect cells from oxidant injury by increasing mitochondrial ATP generation capacity and enhancing cellular glutathione redox cycling2.
  • UCP2 Expression: Ursolic acid stimulates the expression of uncoupling protein 2 (UCP2), which helps to protect cells from hypoxia-reoxygenation injury3.
These properties make ursolic acid a promising compound for supporting mitochondrial health and protecting against oxidative stress.

Would you like more detailed information on any of these points or other topics?

1pubs.rsc.org2onlinelibrary.wiley.com3link.springer.com
 
I don't think any of these can be done successfully. Definition of successful is what I'm questioning. Even if you get it into solution for TD application, something like tesamorelin has like 5% oral bioavailability, injectable is usually close to 100%. If they could get it into TD and make it work the bioavailability is still going to be really low and the amount needed to get a good dose would probably be outrageous. Plus I don't think nos dips his toes in peptides. If RC stuff is on the table then slu-pp and dada could definitely go transdermal. I was really hoping the healing peps would work as TD back when everyone was trying to put it out there. No dice tho. It would be amazing to just rub BPC 157 and TB 500 on my injuries and call it a day

How would it work for penis growth as it cause’s angeogenisis which is great for the hammer. Guessing the other companies heal is not legit then?
 
Today

You​

ursolic acid uncoupling

Copilot​

Ursolic acid has been shown to induce mitochondrial uncoupling, which can have several beneficial effects on cellular health1. Here are some key points:

  • Mitochondrial Uncoupling: Ursolic acid can increase mitochondrial reactive oxygen species (ROS) production, leading to mitochondrial uncoupling1. This process helps to reduce oxidative stress and protect cells from damage1.
  • Glutathione Redox Cycling: Ursolic acid enhances glutathione redox cycling, which is an important antioxidant defense mechanism1.
  • Protection Against Oxidant Injury: Studies have shown that ursolic acid can protect cells from oxidant injury by increasing mitochondrial ATP generation capacity and enhancing cellular glutathione redox cycling2.
  • UCP2 Expression: Ursolic acid stimulates the expression of uncoupling protein 2 (UCP2), which helps to protect cells from hypoxia-reoxygenation injury3.
These properties make ursolic acid a promising compound for supporting mitochondrial health and protecting against oxidative stress.

Would you like more detailed information on any of these points or other topics?

1pubs.rsc.org2onlinelibrary.wiley.com3link.springer.com
Ursolic acid is cool ****. I think a lot of ppl are missing out on this stuff
 
What does it do?
It's in antioxidant, supposed to be cardio protective, protective against cells breaking down so like anti-aging, I believe it's also a nootropic of sorts. It's an amino acid found in certain mushrooms and coffees
 
It's also got a cool name ergo-thioneine sounds like ergogenic which basically means things that enhance athletic performance and endurance
 
sr9009, 🤔 if it doesn't work in an injectable it's not going to work in a topical.
It does work ask wes from gym-n-tonic, he beta tested sr9009 and rad140 TD. People love noopept and others say sr9009 gives a pep in their step, I could see this combo being a great diet aid
 
I know Wes from the boards, and I do agree with a lot of the stuff he posts. I'm not too sure about this one though.
Does it put a pep in your step?
 
I know Wes from the boards, and I do agree with a lot of the stuff he posts. I'm not too sure about this one though.
Does it put a pep in your step?
I don't know but I have been messaging the iron legion email and they talked about sr9009 TD so it is very much a thing, personally some other guys I have DM says clean energy and fatloss is the effects. I am interested mainly from a reversing LVH standpoint as any ped that reverses LVH is a double win IMO
 
Just saw a video on a YouTube... Rob Regish made himself an injectable and a sublingual ecdysterone... and claims it's amazing... wonder how it would be in a transdermal?
 
Wonder how orchic glandular would be in transdermal??? 🤔
 
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Raws for our next new item have been ordered.

It's not something mentioned in here yet but if it does get suggested/guessed that person will still win a free bottle.
 
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