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ursolic acid uncoupling
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Ursolic acid has been shown to induce mitochondrial uncoupling, which can have several beneficial effects on cellular health1. Here are some key points:
- Mitochondrial Uncoupling: Ursolic acid can increase mitochondrial reactive oxygen species (ROS) production, leading to mitochondrial uncoupling1. This process helps to reduce oxidative stress and protect cells from damage1.
- Glutathione Redox Cycling: Ursolic acid enhances glutathione redox cycling, which is an important antioxidant defense mechanism1.
- Protection Against Oxidant Injury: Studies have shown that ursolic acid can protect cells from oxidant injury by increasing mitochondrial ATP generation capacity and enhancing cellular glutathione redox cycling2.
- UCP2 Expression: Ursolic acid stimulates the expression of uncoupling protein 2 (UCP2), which helps to protect cells from hypoxia-reoxygenation injury3.
These properties make ursolic acid a promising compound for supporting mitochondrial health and protecting against oxidative stress.
Would you like more detailed information on any of these points or other topics?
1pubs.rsc.org2onlinelibrary.wiley.com3link.springer.com