The administration of ghrelin in animal studies has resulted in an improvement in food intake, body weight, and lean body mass (LBM) retention [13, 14]. Several clinical trials in human cancer patients have shown that ghrelin was well tolerated and increased food intake [15, 16] and appetite scores [17]. However, due to its short half-life (approximately 30 min) and intravenous administration, the clinical effectiveness of ghrelin remains limited.