So couple things here.
First, most of the ingredients in AE shouldn't be super "time" sensitive, so I wouldn't stress a ton with dosing times.
Everyone is different, but I haven't seen any specific issues with sleep as a consistent pattern for anyone, some even say it improves there sleep. From an anecdotal perspective I often take some with my last meal and sleep 1-2 hours later with zero issues.
Again keeping in mind timing isn't huge you could always just dose all 6 pre if you would like, I know I have enjoyed that and believe that @aaronuconn does it that way as well.
In some (most?) of the Actigin (one of the ingredients in AE) studies they would dose Actigin 1 hour pre and with last meal of the day too, hence that is one of the dosing suggestions I tend to follow.