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amino receptors

Thanks for all the input,,, I came to AM to learn, not put my vast knowledge on display,,, I really do take everything people tell me and put it to further research,,, again, thanks
 
mr.cooper69 said:
That is correct, and has nothing to do with receptors.

Let me clear up what's happening in the small intestine. After peptide cleavage at a variety of primary levels (pepsin in the stomach, pancreatic release of trypsin/chymotrypsin in the duodenum), we have a bunch of small di and tri peptides. From here, these peptides are further cleaved into individual amino acids at the level of the microvilli by enzymes that we will refer to collectively as "brush-border enzymes" for simplicity. However, di/tri peptides can also enter the enterocyte, at which point enzymes within the cell will reduce them to amino acids. No peptides will enter the bloodstream following intestinal absorption; one way or another, they will be individual amino acids.

Here's a nice image depicting this:

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And here's a description from one of my textbooks showing how exactly amino acids are absorbed. I had a much better textbook with an image showing means of absorption for each individual EAA, but I'm on break and don't have access to it. You can PM me in a week if you're still interested.


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I basically said this in a post a page back, nice pics though ;). I believe researchers recently found transport proteins for very short peptides, though.

edit: didnt read it all, I guess you said that too.
 
Mainly asking about the importance of taking aminos individually and separately .... how important is it?
 
grngoloco said:
Why do my arginine and glutamine bottles say to take on empty stomach?
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Because they think free form arginine/glutamine will hit the blood faster without other foods, which is correct. Unfortunately, arginine does not elevate NO nor provide any other worthwhile benefit, and glutamine has failed to improve recovery time and time again. Neither should be your concern. Now you can take BCAAs on an empty stomach to spike blood leucine and maximize MPS.

bigdavid said:
lol cooper I think we used that same book for one of my nutrition classes
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That's one of my mcat prep books so I don't think so ;).
 
mr.cooper69 said:
Because they think free form arginine/glutamine will hit the blood faster without other foods, which is correct. Unfortunately, arginine does not elevate NO nor provide any other worthwhile benefit, and glutamine has failed to improve recovery time and time again. Neither should be your concern. Now you can take BCAAs on an empty stomach to spike blood leucine and maximize MPS.

That's one of my mcat prep books so I don't think so ;).
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I never worried about NO with arginine,,, I was under the impression if taken at very high doses in a 2:1 ratio with ornithine it will stimulate gh release
 
grngoloco said:
I never worried about NO with arginine,,, I was under the impression if taken at very high doses in a 2:1 ratio with ornithine it will stimulate gh release
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It MAY do so but it is not worth it at all. Other things can stimulate GH release without the hassle...not that either will have tangible benefits for body composition. Also keep in mind that arginine attenuates the GH response to exercise.
 
mr.cooper69 said:
It MAY do so but it is not worth it at all. Other things can stimulate GH release without the hassle...not that either will have tangible benefits for body composition. Also keep in mind that arginine attenuates the GH response to exercise.
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Thanks again Cooper ... can always count on your expertise,,, out of curiosity,, other than peptides, what else releases gh?
 
I don't think I've ever read that BCAA should be taken on an empty stomach. If anything I've read to dose them 45min post meal to elevate the uptake of nutrients. I think the empty stomach thing might be a misunderstanding do to the fact that many (currently myself included) dose them mid day on a semi empty stomach to keep protein intake elevated while reducing calories consumed. Its also been mentioned to dose them pre cardio if your doing so in a fasted state.

If I'm not mistaken Lucine on its own can trigger a bit of insulin release. Please correct me if I'm wrong on all fronts.

Great thread BTW.
 
lonewolf0420 said:
I don't think I've ever read that BCAA should be taken on an empty stomach. If anything I've read to dose them 45min post meal to elevate the uptake of nutrients. I think the empty stomach thing might be a misunderstanding do to the fact that many (currently myself included) dose them mid day on a semi empty stomach to keep protein intake elevated while reducing calories consumed. Its also been mentioned to dose them pre cardio if your doing so in a fasted state.

If I'm not mistaken Lucine on its own can trigger a bit of insulin release. Please correct me if I'm wrong on all fronts.

Great thread BTW.
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Earlier in the thread I mentioned that bcaa's needed insulin for absorption,,,, I was talking about individual ff aminos,,, not bcaa's
 
grngoloco said:
Earlier in the thread I mentioned that bcaa's needed insulin for absorption,,,, I was talking about individual ff aminos,,, not bcaa's
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Bcaa's behave a bit differently from some of what I've read,,, but I have A LOT more reading to do
 
lonewolf0420 said:
I don't think I've ever read that BCAA should be taken on an empty stomach. If anything I've read to dose them 45min post meal to elevate the uptake of nutrients. I think the empty stomach thing might be a misunderstanding do to the fact that many (currently myself included) dose them mid day on a semi empty stomach to keep protein intake elevated while reducing calories consumed. Its also been mentioned to dose them pre cardio if your doing so in a fasted state.

If I'm not mistaken Lucine on its own can trigger a bit of insulin release. Please correct me if I'm wrong on all fronts.

Great thread BTW.
Click to expand...

This is false. Spiking MPS while food is still being digested (and absorbed to a mild degree) is redundant. The best time to take your BCAAs would be 2 or more hours postprandially. Correct on the leucine.
 
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