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Agmatine or Citrulline

  • Thread starter Thread starter mtmrfz
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mtmrfz

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As simple as it can be. Which one do you like more? Both can be bought in big quantity for a reasonable price for the amount of goodies it brings.
 
mtmrfz said:
As simple as it can be. Which one do you like more? Both can be bought in big quantity for a reasonable price for the amount of goodies it brings.
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Citrulline has my vote!

I typically buy Cit Malate (2:1) because I love the tangy taste : )

Mixes exceptionally well with Conqu3r (not that its needed for extra pump) and other pres/intras.
 
These two should never need to be separated, it's like peanut butter and jelly, chocolate cake and milk...

But, if I were forced, I would go agmatine.
 
Serious nutrition solutions offers single ingredients such as Agmatine. Very cost effective.
 
jgntyce said:
Serious nutrition solutions offers single ingredients such as Agmatine. Very cost effective.
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Sure does. That's who gets my business for all my staples, Cit Mal included : )
 
It really depends on your goals. For pumps/workouts...maybe citrulline has an edge. For overall health, neural health, etc. - agmatine IMO. I don't really care about pumps at all and use agmatine on a regular basis anyway.
 
I would do both if you can but agmatine if you can't get both.
 
kisaj said:
These two should never need to be separated, it's like peanut butter and jelly, chocolate cake and milk...

But, if I were forced, I would go agmatine.
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Robert5891 said:
Use them together!

If I had to really choose between just one, I'd go with L-Citrulline.
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Its interesting that you guys mentioned that.

Get a read on this:
Does Not Go Well With

L-Arginine and L-Citrulline (for some neurological effects; cardiovascular interactions not well elucidated)

Yohimbine and Rauwolscine (Agmatine activates the α2A receptor that these inhibit)

D-Aspartic Acid due to reducing signalling via the NMDA receptors

Alcohol coingestion (may increase ulceration from alcohol)

Creatine (on the assumption that creatine positively influences NMDA signalling, agmatine works in the opposite manner at the same site; they should not be antagonstic for muscle growth or nitric oxide boosting)

Invalid Link Removed
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Not saying I agree but it was interesting as it tosses this premise in the face of everyone and their sister producing products with both in them that we all quickly discern as efficacious and safe and healthy (remembering the BS arguments from the anti nitrates crowd).

Any merit?
 
Whoa,didn't even think that agmatine doesn't go well with the ingredients above.
 
mtmrfz said:
Whoa,didn't even think that agmatine doesn't go well with the ingredients above.
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Nor did I. Nor am I saying I know enough about the physiology to know for myself but do even the manufacturers know this and/or is this a credible assertion?

I'm not inclined to believe nor consider the bro science guy that says "I've been using both for years and I have no sides" BS statement. Is this a physiological issue or not? Does this source have merit?
 
David Dunn said:
Nor did I. Nor am I saying I know enough about the physiology to know for myself but do even the manufacturers know this and/or is this a credible assertion?

I'm not inclined to believe nor consider the bro science guy that says "I've been using both for years and I have no sides" BS statement. Is this a physiological issue or not? Does this source have merit?
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Very interested to know this as well. Not only will it save me money,but also possible sides if that's true
 
mtmrfz said:
Very interested to know this as well. Not only will it save me money,but also possible sides if that's true
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Anecdotally I have zero issue and they are awesome and efficacious pre workout ingredients that I mix in my home brew formula. But being intelligent and inquisitive I wouldn't mind at least knowing if there is any validity to the neurological and cardiovascular risk.
 
David Dunn said:
Anecdotally I have zero issue and they are awesome and efficacious pre workout ingredients that I mix in my home brew formula. But being intelligent and inquisitive I wouldn't mind at least knowing if there is any validity to the neurological and cardiovascular risk.
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I am fairly certain that what is meant by that is taking those ingredients with agmatine can reduce/diminish some of the beneficial effects agmatine can have on those particular parameters, not that there is a risk in regards to those areas when combining the two. Think how yohimbine doesn't work well with food; it's not dangerous, it's just not effective.
 
David Dunn said:
Its interesting that you guys mentioned that.

Get a read on this:


Not saying I agree but it was interesting as it tosses this premise in the face of everyone and their sister producing products with both in them that we all quickly discern as efficacious and safe and healthy (remembering the BS arguments from the anti nitrates crowd).

Any merit?
Click to expand...

I remember there was a thread that debunked this study. I've tried searching for it but couldn't find it. Perhaps someone can dig it up?
 
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Found the thread. I think Furion largely discounted the effects of a negative interaction. Or at least that's my layman's interpretation!
 
David Dunn said:
Nor did I. Nor am I saying I know enough about the physiology to know for myself but do even the manufacturers know this and/or is this a credible assertion?

I'm not inclined to believe nor consider the bro science guy that says "I've been using both for years and I have no sides" BS statement. Is this a physiological issue or not? Does this source have merit?
Click to expand...

Yep, I am aware of that study but don't give it any credit as there hasn't been anything further to support it and they are not talking about the overall benefits that you can derive from each. From a purely anecdotal standpoint, they work wonderful together and I see the effects more when combined than when taken separately.
 
There are numerous studies that show Agmatine is an A2 agonist. Combining with an antagonist, such as yohimbine, doesn't necessarily mean you will have a side effect...just that the effects may be unpredictable, as one may cancel out the other.

I have taken AGM with Yohimbine and can tell you that Yohimbine appears to be a stronger antagonist than Agmatine is an agonist...as I still feel the yohimbe effects that I am sensitive too.

Agmatine for a pump ingredient, IMO, has less research than for other benefits. Mixing with Citrulline may still be a good pump enhancer, but it appears Citrulline and Arginine may inhibit some of the effects of Agmatine and vv.

Agmatine, IMO, is a complex molecule that isn't just a matter of it does this or that. It appears to have a regulatory function and it looks like it is opening up doors to potential new pathways in biology

Of course, like David Dunn, I am not claiming to be an expert and I am no chemist or biologist. Furion has some good points in the other thread.

I would not worry about sides as much as I would worry about potential cancellation amongst other ingredients.
 
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