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adderall, ritalin / ldopa, bromocritaline

Buffgammaman

Member
would medications like adderal and ritalin be just as good as ldopa and bromocriptaline at lowering prolactin? since they to are dopamine agonists.
 
no. not at all.
Adderall is NOT a dopamine agonist. Aderall depletes your serotonin levels & studies have shown that Adderall actually causes increases in prolactin.
You can also read anecdotal evidence of many people who use Adderall for long periods of time have lose their libido.

Best,
A.
 
Wow I didn't know adderall depleted serotonin. But it's weird that it would raise prolactin. because it's a selective dopamine reuptake inhibitor. meaning it raises dopamine.
 
It creates Dopamine Dysfunction Syndrome.
Your body temporarily overproduces dopamine due to the amphetamine.
This triggers your dopaminergic receptors. At that high level of dopamine they get down-regulated. If you come off amphetamine, your body doesnt make as much to stimulate your dopaminergic receptors- To get that same dopamine high- you have to increase the dosage.
Thats why a lot of people get more depressed/have withdrawl symptoms once they come off adderall. And thats why people take more and more to get the same effects.
 
So to correct my earlier statement- it is, insofar as you take it- but the minute you come down, your receptors are fried. (and thus what dopamine is released would have no effect- effectively you would "feel" a lack of dopamine)
Thus producing the opposite effect.

The in regards to serotonin- amphetamines trigger the release of serotonin from synaptic vesicles.
When you come off amphetamines - your brain is in a temporary defeceit of serotonin.

Methamphetamine
(not dextro, or levo amphetamines found in adderall)
can stimulate serotonin as well as dopamine and norepinephrine.

Ritalin is an inverse agonist of serotonin receptors.

Bromocriptine is a dopamine agonist- why would you want to couple this with adderall?

PS: here is a Amphetmine = prolactin study:


d-Amphetamine raises serum prolactin in man: Evaluations after chronic placebo, lithium and pimozide treatment
Daniel P. van Kammen M.D.Ph.D.*, John P. Docherty M.D.**, Stephen R. Marder M.D.***, Samuel G. Siris M.D.**** and William E. Bunney Jr. M.D.*

*Biological Psychiatry Branch, DCBR, IRP, NIMH, The Clinical Center, NIH, Bethesda, Maryland 20014, USA

**VA Hospital, West Haven, Connecticut, USA

***VA Hospital/Brentwood, Brentwood, California, USA

****New York Psychiatric Institute, New York, New York, USA

Revised 22 August 1978.
Available online 4 November 2002.

Invalid Link Removed
Click to expand...
 
Antigravity said:
So to correct my earlier statement- it is, insofar as you take it- but the minute you come down, your receptors are fried. (and thus what dopamine is released would have no effect- effectively you would "feel" a lack of dopamine)
Thus producing the opposite effect.

The in regards to serotonin- amphetamines trigger the release of serotonin from synaptic vesicles.
When you come off amphetamines - your brain is in a temporary defeceit of serotonin.

Methamphetamine
(not dextro, or levo amphetamines found in adderall)
can stimulate serotonin as well as dopamine and norepinephrine.

Ritalin is an inverse agonist of serotonin receptors.

Bromocriptine is a dopamine agonist- why would you want to couple this with adderall?

PS: here is a Amphetmine = prolactin study:
Click to expand...


Ok now we know it has the opposite effect on prolactin then what you want the question is why. because amphetmines raise dopamine it shouldn't be doing this. and don't say it's because it raises serotonin because adderall has no effect on serotonin.
 
Antigravity said:
I think youre misread my comments.
Additionally I corrected myself where I was wrong.

Best,
Click to expand...


Wait what did you say that was wrong? I think you've been right about the dependancy thing with adderal and the like and how it can down regulate receptors but I just don't know about it causeing higher prolactin.

Also isn't there a risk of down regulating receptors with l dopa and bromocriptine as well or no?
 
I believe Ritalin, not Adderall as effectively, would serve as an anti-prolactin... Why? Because all the anti-prolactin medications (pramipexole, dostinex, etc.) are simply mimicking dopamine. Ritalin is a Dopamine re-uptake inhibitor, thus causes high levels of Dopamine - and it effectively works as a anti-prolactin. Ritalin is also causes a release in norepinephrine, which raises the metabolism significantly, thus the stimulant effect. So, yes... It would, and does.
 
hopefully you plan on taking it every 4 hours or more often than that even...

Methylphenidate exerts its therapeutic effects via blocking the reuptake of dopamine into nerve terminals (as well as stimulating the release of dopamine from dopamine nerve terminals) resulting in increased dopamine levels in the synapse. [111][117] The onset of central nervous system effects occurs rapidly after intake of methylphenidate and persist for about 4 hours.[118] The mechanism of action is comparable with that of cocaine with usual doses of both drugs occupying 50% of dopamine transporters.
Click to expand...
 
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