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7,8 benzoflavone standalone bulk

green1990

New member
Any body know where I can get 7,8 benzoflavone standalone bulk powder or any alternatives. I know about resV100, demacrine and 7,8 benzoflavone complex and cant use them cause they all contain reserveratrol and that causes me insomnia by increased cortisol production.
 
green1990 said:
Any body know where I can get 7,8 benzoflavone standalone bulk powder or any alternatives. I know about resV100, demacrine and 7,8 benzoflavone complex and cant use them cause they all contain reserveratrol and that causes me insomnia by increased cortisol production.
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I am assuming you are looking for an estrogen product. Erase or Erase Pro may better suit your needs
 
xhrr said:
Resveratrol increases cortisol?
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Endocrinology. 2012 Jul;153(7):3258-68. doi: 10.1210/en.2011-2088. Epub 2012 May 14.
Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc.
Li D1, Dammer EB, Sewer MB.
Author information
Abstract

"In the human adrenal cortex, cortisol is synthesized from cholesterol by members of the cytochrome P450 superfamily and hydroxysteroid dehydrogenases. Both the first and last steps of cortisol biosynthesis occur in mitochondria. Based on our previous findings that activation of ACTH signaling changes the ratio of nicotinamide adenine dinucleotide (NAD) phosphate to reduced NAD phosphate in adrenocortical cells, we hypothesized that pyridine nucleotide metabolism may regulate the activity of the mitochondrial NAD(+)-dependent sirtuin (SIRT) deacetylases. We show that resveratrol increases the protein expression and half-life of P450 side chain cleavage enzyme (P450scc). The effects of resveratrol on P450scc protein levels and acetylation status are dependent on SIRT3 and SIRT5 expression. Stable overexpression of SIRT3 abrogates the cellular content of acetylated P450scc, concomitant with an increase in P450scc protein expression and cortisol secretion. Mutation of K148 and K149 to alanine stabilizes the expression of P450scc and results in a 1.5-fold increase in pregnenolone biosynthesis. Finally, resveratrol also increases the protein expression of P450 11β, another mitochondrial enzyme required for cortisol biosynthesis. Collectively, this study identifies a role for NAD(+)-dependent SIRT deacetylase activity in regulating the expression of mitochondrial steroidogenic P450."

I felt the cortisol response for myself, in prone individuals but I know what a cortisol spike feels like, all reserveratrol, tongkat, curcumin 5htp, spikes my cortisol all the same
 
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