6-bromodione and PCT (legit concerns)

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FitnFirm said:
FREE RESTORE FOR EVERYONE
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Hey Fit, am I too late? I was at a company softball game when all of this was going on. I LOVE RESTORE! I've used about 4 bottles, and have a 5th I'll be opening in about 6 weeks. :D I've used it in P.C.T. and as a test-booster in-between. I always feel good overall when I have my Restore.
 
Fit,
I'm always up for free stuff. (But - you already know that.)


BTW - new JW logo's look awesome. Good job on them.
 
Patrick Arnold said:
i know your intentions are good but i wonder if you even realize that you just basically offered to give away free anabolic steroids to everyone

not that there is necessarily anything wrong about that....

just check their ages, please
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NO, our product is not steroids. I know all these guys and they are all over 21, thats the first thing I check.
 
Patrick Arnold said:
if you wanna be natural you can't take any kind of steroid compound except i think 7-keto dhea. that includes 6-oxo, 6- bromo, JW etc

at least that is how i understand the rules are now
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OK Im not using Cissus Drol, which I was given two bottles for free. Thank you Patrick you have saved me a lot of research.

Your trouble making abilities are sometimes humerous =)
 
PA If you wanted to you could do a chemical workshop or seminar. ID take it ,covering all natural bodybodybuilding , its your seminar.and willing the pay the price; provided that the money is in my possession at the time. Im sure many others would too. Just a thought.

We might can do business in the future in the bodybuilding Industry..just an idea, and Ill ask when the money is in my hands.
 
FitnFirm said:
NO, our product is not steroids. I know all these guys and they are all over 21, thats the first thing I check.
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correct me if i am wrong but is one of the ingredients in restore 6alpha-bromoandrostenedione?

in that case it is a direct precursor to an androgenic-anabolic steroidal chemical
 
smeton_yea said:
PA If you wanted to you could do a chemical workshop or seminar. ID take it ,covering all natural bodybodybuilding , its your seminar.and willing the pay the price; provided that the money is in my possession at the time. Im sure many others would too. Just a thought.

We might can do business in the future in the bodybuilding Industry..just an idea, and Ill ask when the money is in my hands.
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that is something i might consider. it is very troubling how so many people are misled about products on the market today. things have gotten out of control. androgenic steroids are being mislabeled as PCT therapy, plant sterols are being misrepresented as anabolic agents, and across the board science is being manipulated if not downright fabricated. its gone way too far. Sometimes i feel like i am the only one who knows what is going on and/or cares
 
Patrick Arnold said:
correct me if i am wrong but is one of the ingredients in restore 6alpha-bromoandrostenedione?

in that case it is a direct precursor to an androgenic-anabolic steroidal chemical
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Well maybe at a higher dosage it could be something more than what it is in our product, it is an AI.


Stereochemistry of the functional group determines the mechanism of aromatase inhibition by 6-bromoandrostenedione
Y Osawa, Y Osawa and MJ Coon


A selective inhibitor of aromatase (estrogen synthetase) would be a useful pharmacological tool with potential therapeutic application. We have found that 6 alpha-bromoandrostenedione (6 alpha-BrA) is a competitive inhibitor of human placental aromatase with respect to androstenedione, with an apparent Ki of 3.4 nM, while 6 beta-BrA is a mechanism-based irreversible inhibitor with an apparent Ki of 0.8 microM and a kinact of 0.025 min-1. Aromatase activity was measured by tritium release into water from the 1 beta position of [1(-3)H,4(- 14)C]androstenedione in reaction mixtures containing NADPH and the aromatase. Time-dependent inhibition was assessed by preincubation of inhibitors with either the 900 X g placental pellet or placental microsomes in the presence of NADPH. Aliquots were taken at intervals, diluted, and assayed for aromatase activity with androstenedione and additional NADPH. The time-dependent inhibition by 6 beta-BrA was dependent on the concentration of this compound and the presence of NADPH, while the addition of excess substrate in the preincubation mixture hindered the inactivation. Both epimers were ineffective in inhibiting rabbit liver microsomal drug-metabolizing activities in a competitive or time-dependent manner. This indicates a high selectivity of 6-BrA inhibition among P-450 cytochromes. These and other 6- substituted androgens may be useful probes into the nature of the active site and mechanism of action of aromatase.
 
We all know Patrick is on on of his game in this feild..aka Patrick is an expert, its time people reconize..the feild of chemicals ..whats the word for it? Chemistry
 
Pretty fascinating stuff if you ask me :D







Inhibition of estrogen synthesis in human breast tumors by testololactone and bromoandrostenedione




Budnick RM; Dao TL


The inhibition of aromatase enzyme in human breast tumors by delta 1-testololactone, testololactone, 6 alpha-bromoandrostenedione, and 6 beta-bromoandrostenedione was investigated. Estrone and estradiol synthesis from androstenedione was reduced in 3 tumor incubations by the presence of 0.13 mM delta 1-testololactone and testololactone. 6 alpha- and 6 beta-bromoandrostenedione (2.0 microM) were also shown to block estrogen synthesis in 2 tumors. Furthermore, Lineweaver-Burk plots revealed that all 4 compounds are competitive inhibitors of androstenedione aromatization. An apparent Km of the aromatase enzyme for androstenedione of 0.08 microM and a Vmax of 23 pmol of estrone synthesized/g tumor/hr were determined for one human breast tumor specimen. These results demonstrate that these aromatase inhibitors may be useful for the treatment of breast cancer.
 
companies and people will do anything, IN THIS CASE MISLEAD PEOPLE AND RISK LIVES to make a dollar, what a crooked people and market!!!!!!. If your product does contain any of these compounds you need to make it known otherwise if a person has no knowledge and doesnt know EXACTLTY what the chemical does, than in some cases they suffer.
 
smeton_yea said:
We all know Patrick is on on of his game in this feild..aka Patrick is an expert, its time people reconize..the feild of chemicals ..whats the word for it? Chemistry
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Stop being a butt licker Smeton :rant: This convo is not about a PERSON, its about compounds. Put your tongue back in your mouth.
 
Its just stating facts fit . You however are not on top of this feild. Thanks for contributing what you have. and I cant help it I like patrick better than you, he obviously is a better person. are you on drugs or have you been for a while? for how long? You sure act like it sometimes. Lets keep this objectively and not TRY to play people or we can play people=).
 
Im sure it converts to a ps/ph in the body however, I wouldnt be surprised if it converts at such a low level it has negilable effects as a performance enhancer not to mention long term shutdown or other typical effects seen of phs.

As fit said, Im sure mass dosed you might see something from it. Like I said initially. Ill provide bloodwork after pct has ended in early july to show effects on test levels etc.
 
V00D00 said:
Im sure it converts to a ps/ph in the body however, I wouldnt be surprised if it converts at such a low level it has negilable effects as a performance enhancer not to mention long term shutdown or other typical effects seen of phs.

As fit said, Im sure mass dosed you might see something from it. Like I said initially. Ill provide bloodwork after post cycle therapy has ended in early july to show effects on test levels etc.
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Id be interested in following it. I do not know the correct dosage of cissus-drol, if it is EXTREMELY low , so low that it REALLy doesnt matter, maybe and just maybe.and I will by no means negiogiate my natural ways. so its best I just leave it aloneintill i KNOW for a FACt it wont do anything.
 
smeton_yea said:
Id be interested in following it. I do not know the correct dosage of cissus-drol, if it is EXTREMELY low , so low that it REALLy doesnt matter, maybe and just maybe.and I will by no means negiogiate my natural ways. so its best I just leave it aloneintill i KNOW for a FACt it wont do anything.
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I'm not trying to sound mean here, but if you're that worried about taking something that may compromise your "natural ways", why don't you just stick to all natural things like food and weights?
 
PA you should:

1. Have you own subsection

2. Start making some videos or something that people could buy / watch to learn about the wonders of steroids and how they work etc.

3. Do something fun and good for all mankind :)

<3 Neoborn <3

Good job on the opening post...doesn't sound too agressive.
 
Zombie said:
i might be able to help in that department im always available for some sadistic/gory sh!t :)




Zombie goes and look for his "ToolBox"
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I thought about sharpening my tools then I said wait ! No, blunt dull crap hurts a helluva lot more :D:twisted:
 
rpen22 said:
I'm not trying to sound mean here, but if you're that worried about taking something that may compromise your "natural ways", why don't you just stick to all natural things like food and weights?
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I do and I also go by the guidelines natural body builders use. 6-oxo ,and I beleive 6-Bromo are banned by the Natural bodybuildign drug tests...I said IF and only IF the 6-bromo is so small of an amount it doesnt matter and if I can get away with it I might do it. I m not going to persue it, if I find out I can , maybe. Its best not to play (6-bromo) if you are not sure and thats what Im doing. Tribulus, Fenugreek and Coleus forskohli,however are ok with Natural bodybuilding regulations. aka they dont show up on test. I have never competed as a natural bodybuilder and would like it; however its not my main proierty, work is , and I might comepete someday. It depends on if I have the time and money too. rpen do you see what I mean
 
smeton_yea said:
rpen do you see what I mean
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I do, but I just meant if you want to be completely natural, why even use any supplements at all.

BTW, I compete as a natural NPC competitor. None of the supplements I've used are banned by my organization, yet some might not agree with them being "natural"(Patrick:D). I'm not breaking any rules, however many of the guys I compete against are blatantly doing so.
 
rpen22 said:
I do, but I just meant if you want to be completely natural, why even use any supplements at all.

BTW, I compete as a natural NPC competitor. None of the supplements I've used are banned by my organization, yet some might not agree with them being "natural"(Patrick:D). I'm not breaking any rules, however many of the guys I compete against are blatantly doing so.
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Much Respect to you. have you ever gotten first place?
 
FitnFirm said:
Well maybe at a higher dosage it could be something more than what it is in our product, it is an AI.


Stereochemistry of the functional group determines the mechanism of aromatase inhibition by 6-bromoandrostenedione
Y Osawa, Y Osawa and MJ Coon

.
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this article is not relevant to the topic of androgenic activity fitnfirm

so why did you post it?
 
V00D00 said:
Im sure it converts to a ps/ph in the body however, I wouldnt be surprised if it converts at such a low level it has negilable effects as a performance enhancer not to mention long term shutdown or other typical effects seen of phs.
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i don't necessarily disagree with you however it certainly is NOT the best choice for testicular recovery

for testicular recovery you need a pure anti-estrogen product with no competing HPTA inhibitor androgenic action

much like with formestane
 
smeton_yea said:
rpen22 said:
smeton_yea said:
Id be interested in following it. I do not know the correct dosage of cissus-drol, if it is EXTREMELY low , so low that it REALLy doesnt matter, maybe and just maybe.and I will by no means negiogiate my natural ways. so its best I just leave it aloneintill i KNOW for a FACt it wont do anything.
Click to expand...
I'm not trying to sound mean here, but if you're that worried about taking something that may compromise your "natural ways", why don't you just stick to all natural things like food and weights?
Click to expand...
I do and I also go by the guidelines natural body builders use. 6-oxo ,and I beleive 6-Bromo are banned by the Natural bodybuildign drug tests...I said IF and only IF the 6-bromo is so small of an amount it doesnt matter and if I can get away with it I might do it. I m not going to persue it, if I find out I can , maybe. Its best not to play (6-bromo) if you are not sure and thats what Im doing. Tribulus, Fenugreek and Coleus forskohli,however are ok with Natural bodybuilding regulations. aka they dont show up on test. I have never competed as a natural bodybuilder and would like it; however its not my main proierty, work is , and I might comepete someday. It depends on if I have the time and money too. rpen do you see what I mean
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You are trying to blur the line...

And with a sig like: "Anabolic free and proud of it. It's more of a challange this way to lift the heavy weights."

Not only should you avoid supplements, I would avoid the gym. You should do that strongman type of workouts. GO throw some rocks around, pull and push cars. Now that would be a challenge.
 
Mass_69 said:
That last comment about formestane could be taken either way. To clarify, I think you mean that formestane is an example of an anti-estrogen with androgenic HPTA inhibition, of course when converted to 4-OH-testosterone.
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thats what i meant

the scant studies published on formestane in men has shown estrogen suppression with little or no testosterone elevation

the same would probably be expected with 6-bromodione, unless it was predominantly beta isomer
 
xjsynx said:
You are trying to blur the line...

And with a sig like: "Anabolic free and proud of it. It's more of a challange this way to lift the heavy weights."

Not only should you avoid supplements, I would avoid the gym. You should do that strongman type of workouts. GO throw some rocks around, pull and push cars. Now that would be a challenge.
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you might be right. Goodluck with the the un natural supplements your taking
 
Hey PA

What is the difference between a PH and PS? Aren't they a same thing that they convert to steroids in the liver?
 
Solitude said:
Hey PA

What is the difference between a PH and PS? Aren't they a same thing that they convert to steroids in the liver?
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not pa but..a ph is a precursor to a hormone and ps is a pure hormone,no conversion nescessary
 
prohormone= conversion to a natural hormone (Test, estrogen, cort,DHT, etc)

Prosteroid= conversion to synthetic man made steroid (Tren,dbol,deca, etc)
 
Hyde12 said:
prohormone= conversion to a natural hormone (Test, estrogen, cort,DHT, etc)

Prosteroid= conversion to synthetic man made steroid (Tren,dbol,deca, etc)
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it has nothing to do with natural unnatural

a prosteroid is a active hormone..think 1-ad / 1-test..1-ad being a ph requiring activation and 1-test is active
 
wojo said:
it has nothing to do with natural unnatural

a prosteroid is a active hormone..think 1-ad / 1-test..1-ad being a ph requiring activation and 1-test is active
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nope, 1-ad and 1-test are prohormones because you have 1-test in your body, you do not however have tren naturally in your body. You have to go back to the definition of a steroid.
Which is a man-made modification of a hormone.
 
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Hyde12 said:
nope, 1-ad and 1-test are prohormones because you have 1-test in your body, you do not however have tren naturally in your body. You have to go back to the definition of a steroid.
Which is a man-made deriative of a hormone.
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your kidding me reread what you just said!!!!..whatever i am not hijacking this thread..believe what you want
 
wojo said:
it has nothing to do with natural unnatural

a prosteroid is a active hormone..think 1-ad / 1-test..1-ad being a ph requiring activation and 1-test is active
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ok ok let me get this straight, so either way they are still a precursor to a steroid correct? and the difference between them only ph requires activation and ps is an active compound already, yeah?
 
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