5 htp with or without b6

[rhoadx]

With the goal of increasing serotonin in the brain, would it be better to avoid taking b6 with 5htp? The thinking being that the 5htp would convert to serotonin before it can reach the brain, and not be able to cross the bbb if taken with b6.

 

[johnnyp]

Generally I would suggest against supplementing with extra b6 if it is in the form of pyridoxine due to fear of neuropathy.

 

[kisaj]

It's unnecessary and inconsequential. B6 will make no difference.

 

[rhoadx]

^ I thought b6 was a cofactor in the metabolism of 5-htp to serotonin

 

[kisaj]

5-HTP raises brain seratonin levels with or without B6. There is a small study that showed that it helped conversion in rat brains, but there is no solid evidence that it is necessary or even helpful when taking 5-HTP as a supplement.

 

[rhoadx]

Cool. Thanks man. I've been avoiding taking the two together due to fear of it converting too soon

 

[EasyEJL]

at the very least if you're going to do it, stay low at 50mg or so and go with P5P