I have been thinking for some time now about an impact of dht and dht like substances on our body, mood, libido etc. Also, the impact those substances have in a cycle, their desired and undesired effects.
I for one would be interested in increasing my DHT levels.
As far as I know, there are no known ways of increasing 5 alpha reductase activity within the body as there is for increasing aromatase activity, such as high doses of hcg, beer, being fat and so on.
Injectable T seems to be converting to DHT at a lower rate than either endogenous T (as there is high concentration of 5 ar within the testicles) and especially than transdermal, or even scrotal T creams, as there is also high concentration of 5 ar in the skin.
Some people report feeling more of a boost with a cream. Perhaps it is the dht? Likely.
Also, some people using injectable T for trt report not feeling good, and then they list their bloodwork showing low, or low-normal dht levels.
So what are the options for increasing dht if so far we are only using injectable testosterone and not dht like substances?
Well, the first option would be to add in a dose of scrotal T cream everyday. Another option would be to use dht gel itself, or perhaps, an injectable form of dht.
Masteron and proviron are the closest available substitutes for dht, but they are NOT dht. They are often called dht's, but they are merely dht derivatives.
For example, masteron is often quoted to be the closest thing to dht. Well, the first big difference is that masteron is 2 alpha methyl dht and therefore it retains anabolic potency within the muscle.
HOWEVER, even though masteron has some potency in the muscle (or should i say, it remains masteron within the muscle and is not deactivated and turned into other metabolites), it has SIGNIFICANTLY lower binding affinity for androgen receptor than natural DHT.
If it retained the androgen receptor binding affinity of natural dht, it would be much more potent than testosterone at building lean tissue, which is obviously not the case,
Natural DHT is said to have binding affinity about 3x that of the testosterone. So natural DHT is a much more potent androgen, and if it wasnt deactivated in the muscle, it would be extremely potent at building tissue, similar to trenbolone (which is said to to bind to androgen receptor at 3x the affinity of testosterone).
Proviron is 1 alpha methyl dht, and because of that, has slight oral bioavailability. But it is still NOT dht. It also has MUCH lower binding affinity for the androgen receptor than natural dht.
So what do we know so far? Natural DHT is much more potent androgen than either proviron or masteron.
Testosterone itself is considered more androgenic and produces more virilization in women than either proviron or masteron (masteron was "safer" for women with breast cancer as at the same dose it produced significantly less virilization than testosterone ester), because of its conversion to dht, which is more potent androgen than either masteron or proviron.
Dht, proviron and masteron have similar benefits. They all somewhat antagonize estrogen and prolactin receptor and therefore counter some estrogenic sides. How does dht do that? Well, i will take a guess and use occam's razor, and say it merely binds to the receptor occupying space and preventing estradiol from binding.
They are often quoted to be AI's. They are potentially slight ai's. They will not lower concentration of estradiol significantly, although some of the dht/mast/proviron might bind with aromatase and therefore occupy space reserved for testosterone, in effect lowering the concentration of estradiol.
But they have double action. Other than just binding with aromatase enzyme (i dont know how high the affinity is compared to aromatase inhibitors), they also antagonize the estrogen receptor itself, providing more of an anti estrogenic effect than just stopping T->E2 conversion.
So some of my ongoing quests are:
1) Finding a way, if possible, of increasing 5 alpha reductase enzyme concentration in the body so that more of the injected testosterone is converted to dht.
2) To find out whether someone ever used injectable androstanolone (natural dht) and what were the results?
Also people who used the DHT gel, did they notice positive results in terms of mood, libido, strength and muscle hardness (loss of subQ water)?
3) When and if i get my hands on either injectable or transdermal natural DHT, compare its effects to both masteron and proviron.
What are your thoughts on this?
I for one would be interested in increasing my DHT levels.
As far as I know, there are no known ways of increasing 5 alpha reductase activity within the body as there is for increasing aromatase activity, such as high doses of hcg, beer, being fat and so on.
Injectable T seems to be converting to DHT at a lower rate than either endogenous T (as there is high concentration of 5 ar within the testicles) and especially than transdermal, or even scrotal T creams, as there is also high concentration of 5 ar in the skin.
Some people report feeling more of a boost with a cream. Perhaps it is the dht? Likely.
Also, some people using injectable T for trt report not feeling good, and then they list their bloodwork showing low, or low-normal dht levels.
So what are the options for increasing dht if so far we are only using injectable testosterone and not dht like substances?
Well, the first option would be to add in a dose of scrotal T cream everyday. Another option would be to use dht gel itself, or perhaps, an injectable form of dht.
Masteron and proviron are the closest available substitutes for dht, but they are NOT dht. They are often called dht's, but they are merely dht derivatives.
For example, masteron is often quoted to be the closest thing to dht. Well, the first big difference is that masteron is 2 alpha methyl dht and therefore it retains anabolic potency within the muscle.
HOWEVER, even though masteron has some potency in the muscle (or should i say, it remains masteron within the muscle and is not deactivated and turned into other metabolites), it has SIGNIFICANTLY lower binding affinity for androgen receptor than natural DHT.
If it retained the androgen receptor binding affinity of natural dht, it would be much more potent than testosterone at building lean tissue, which is obviously not the case,
Natural DHT is said to have binding affinity about 3x that of the testosterone. So natural DHT is a much more potent androgen, and if it wasnt deactivated in the muscle, it would be extremely potent at building tissue, similar to trenbolone (which is said to to bind to androgen receptor at 3x the affinity of testosterone).
Proviron is 1 alpha methyl dht, and because of that, has slight oral bioavailability. But it is still NOT dht. It also has MUCH lower binding affinity for the androgen receptor than natural dht.
So what do we know so far? Natural DHT is much more potent androgen than either proviron or masteron.
Testosterone itself is considered more androgenic and produces more virilization in women than either proviron or masteron (masteron was "safer" for women with breast cancer as at the same dose it produced significantly less virilization than testosterone ester), because of its conversion to dht, which is more potent androgen than either masteron or proviron.
Dht, proviron and masteron have similar benefits. They all somewhat antagonize estrogen and prolactin receptor and therefore counter some estrogenic sides. How does dht do that? Well, i will take a guess and use occam's razor, and say it merely binds to the receptor occupying space and preventing estradiol from binding.
They are often quoted to be AI's. They are potentially slight ai's. They will not lower concentration of estradiol significantly, although some of the dht/mast/proviron might bind with aromatase and therefore occupy space reserved for testosterone, in effect lowering the concentration of estradiol.
But they have double action. Other than just binding with aromatase enzyme (i dont know how high the affinity is compared to aromatase inhibitors), they also antagonize the estrogen receptor itself, providing more of an anti estrogenic effect than just stopping T->E2 conversion.
So some of my ongoing quests are:
1) Finding a way, if possible, of increasing 5 alpha reductase enzyme concentration in the body so that more of the injected testosterone is converted to dht.
2) To find out whether someone ever used injectable androstanolone (natural dht) and what were the results?
Also people who used the DHT gel, did they notice positive results in terms of mood, libido, strength and muscle hardness (loss of subQ water)?
3) When and if i get my hands on either injectable or transdermal natural DHT, compare its effects to both masteron and proviron.
What are your thoughts on this?