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Bioavailability of oral TNE is around 5% from what I’ve seen and half life is very short.

How often should dermaroller be replaced? I read at some p’aces that it should be replaced every like 10 uses. If this is the case it can be expensive if buying quality ones.

I would say around 18%

I think many companies selling 200:1 extracts are not transparent on their labels. And believe they refer to 200:1 extract based on fresh root not root powder. Which would be equivalent to 20mg 200:1 powder. This is what I saw reading the label tongkat from pipingrock. Maybe I’m wrong. I...

My eGFR is around 85-87 without proteinuria, at 52 years old. None of my physicians have seen any problem with this and didn’t talk about CKD. I’m kind of concerned but not them.

Correct. Anything above 60 is considered normal in the absence of other abnormal markers, like proteinuria.

Does it’s mental effect fade away with continuous use?

what are your kidney and liver parameters values, and their trend?

Il was more to know if it is worth it to make it transdermal. We know that the bioavailability of a transdermal is roughly 20-30% at best with some good carrier. But if the oral bioavailability is about the same I’m not going to make a transdermal out of it.

Bumping up this old thread not create a new one. does anybody know about the absoption/bioavailability of oral 11-oxo? not talking about 11-KT or sublingual 11-ox. But just plain old 11-oxo? Old non-methylated prehormones have an oral bioavailability of 5-10%. Was wondering if it would be the...

Actually in majority of the cases beef protein powder is one of the poorest options for a protein powder. Many if not all the beef protein powders out there are mainly collagen, which has a BV close to zero. I’ve never seen one single brand saying how much of their protein comes from collagen...

I’m here since 2004. I’m not posting often so I’m almost invisible :) I still enjoy reading some of the old members here, like Dr. D, but dont see many left.

And you are almost 2 years late :)

Unflavored Carb10 for me.

Did you notice partitioning effect the next day doing that?

Do you take your metformin before bed and not before/at meals? I’m still trying to find how I can use metformin best for its insulin sensitivity and GDA action.

For me with all the capsules and powders I’m taking, having some of the supplements in a TD is a good thing.

Why do you want to have a TRT if your testosterone is in the range?

True. Good point.

Oral apigenin seems to have a bioavailability of 30%. Not sure making it transdermal would make it any better. But who knows.