Dr. John said:
There are several flaws in this post.
It doesn't matter how much T is bound to SHBG, as I monitor same, and titrate dose to effect. This post instead should refer to UNTREATED men, and describes the effects of increasing SHBG levels as we age. But I overcome that.
And as we now know, DHT is not the culprit in prostate morbidity. Estrogen is.
"Binding capacity" of SHBG actually refers to the amount of SHBG, not its particular affinity. If SHBG actually gets better at binding T as we age, I would like to know that.
----------All Im trying to say is--If you use outside source of test or not that stinging nettle can 1]raise natural test 2]is best for all prostate issues---including removing estrogen from prostate ----------------------------------------------------------
The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes.
Hryb DJ, Khan MS, Romas NA, Rosner W Department of Medicine, St. Luke's/Roosevelt Hospital Center, New York, N.Y. 10019. Planta Med 1995 Feb;61(1):31-2
Extracts from the roots of the stinging nettle (Urtica dioica) are used in the treatment of benign prostatic hyperplasia. The mechanisms underlying this treatment have not been elucidated. We set out to determine whether specific extracts from U. dioica had the ability to modulate the binding of sex hormone-binding globulin to its receptor on human prostatic membranes. Four substances contained in U. dioica were examined: an aqueous extract; an alcoholic extract; U. dioica agglutinin, and stigmasta-4-en-3-one. Of these, only the aqueous extract was active. It inhibited the binding of 125I-SHBG to its receptor. The inhibition was dose related, starting at about 0.6 mg/ml and completely inhibited binding at 10 mg/ml.
Effects of stinging nettle root extracts and their steroidal components on the Na+,K(+)-ATPase of the benign prostatic hyperplasia.
Hirano T, Homma M, Oka K Department of Clinical Pharmacology, Tokyo College of Pharmacy, Japan. Planta Med 1994 Feb;60(1):30-3
The effects of organic-solvent extracts of Urtica dioica (Urticaceae) on the Na+,K(+)-ATPase of the tissue of benign prostatic hyperplasia (BPH) were investigated. The membrane Na+,K(+)-ATPase fraction was prepared from a patient with BPH by a differential centrifugation of the tissue homogenate. The enzyme activity was inhibited by 10(-4)-10(-5) M of ouabain. The hexane extract, the ether extract, the ethyl acetate extract, and the butanol extract of the roots caused 27.6-81.5% inhibition of the enzyme activity at 0.1 mg/ml. In addition, a column extraction of stinging nettle roots using benzene as an eluent afforded efficient enzyme inhibiting activity. Steroidal components in stinging nettle roots, such as stigmast-4-en-3-one, stigmasterol, and campesterol inhibited the enzyme activity by 23.0-67.0% at concentrations ranging from 10(-3)-10(-6) M. These results suggest that some hydrophobic constituents such as steroids in the stinging nettle roots inhibited the membrane Na+,K(+)-ATPase activity of the prostate, which may subsequently suppress prostate-cell metabolism and growth.
The inhibiting effects of Urtica dioica root extracts on experimentally induced prostatic hyperplasia in the mouse.
Lichius JJ, Muth C Institut fur Pharmazeutische Biologie, Philipps-Universitat, Marburg, Germany. Planta Med 1997 Aug;63(4):307-10
Extracts of stinging nettle roots (Urtica dioica L. Urticaceae) are used in the treatment of benign prostatic hyperplasia (BPH). We established a BPH-model by directly implanting an urogenital sinus (UGS) into the ventral prostate gland of an adult mouse. Five differently prepared stinging nettle root extracts were tested in this model. The 20% methanolic extract was the most effective with a 51.4% inhibition of induced growth.
Aromatase inhibitors from Urtica dioica roots
Gansser D.; Spiteller G. Lehrstuhl Organische Chemie 1, Universitat Bayreuth, NW I, Universitatsstrasse 30,D-95440 Bayreuth Germany Planta Medica (Germany) 1995, 61/2 (138-140)
Methanolic extracts of stinging nettle (Urtica dioica L.) roots were investigated for aromatase inhibition. Enzyme inhibition was detected only after appropriate chromatographic separation. Inhibitory effects on aromatase could be demonstrated in vitro for a variety of compounds belonging to different classes. The following compounds developed weak to moderate activity: secoisolariciresinol (1), oleanolic and ursolic acid (2 and 3), (9Z,11E)-13-hydroxy-9,11-octadecadienoic acid (4), and 14-octacosanol (5). Inhibitory effects on aromatase have been known to date neither for pentacyclic triterpenes nor for secondary fatty alcohols. The potential physiological significance of the above findings is discussed. Compound 5 is a previously unknown constituent of plants.
Effects of stinging nettle root extracts and their steroidal components on the Nasup +,Ksup +-ATPase of the benign prostatic hyperplasia
Hirano T.; Homma M.; Oka K. Dept. of Clinical Pharmacology, Tokyo College of Pharmacy, 1432-1 Horinouchi,Hachioji, Tokyo 192-03 Japan Planta Medica (Germany) 1994, 60/1 (30-33)
The effects of organic-solvent extracts of Urtica dioica (Urticaceae) on the Nasup +,Ksup +-ATPase of the tissue of benign prostatic hyperplasia (BPH) were investigated. The membrane Nasup +,Ksup +-ATPase fraction was prepared from a patient with BPH by a differential centrifugation of the tissue homogenate. The enzyme activity was inhibited by 10sup -sup 4-10sup -sup 5 M of ouabain. The hexane extract, the ether extract, the ethyl acetate extract, and the butanol extract of the roots caused 27.6-81.5% inhibition of the enzyme activity at 0.1 mg/ml. In addition, a column extraction of stinging nettle roots using benzene as an eluent afforded efficient enzyme inhibiting activiry. Steroidal components in stinging nettle roots, such as stigmast-4-en-3-one, stigmasterol, and campesterol inhibited the enzyme activity by 23.0-67.0% at concentrations ranging from 10sup -sup 3-10sup -sup 6 M. These results suggest that some hydrophobic constituents such as steroids in the stinging nettle roots inhibited the membrane Nasup +,Ksup +-ATPase activity of the prostate, which may subsequently suppress prostate-cell metabolism and growth.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany. Planta Med 1997 Dec;63(6):529-32
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
