Contest to Celebrate Scivation’s Return to AM

Reason #45 to not fall asleep
at your buddy's house.
 

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xjsynx said:
3 scoops Xtend + Poseidon 1st thing in the morning, lunch, and before bed.

6-9 scoops pre-peri workout.
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Ever have trouble sleeping when taking xtend before bed?
I tried that once and felt like it took me much longer to fall asleep, but only ever done this one time because I like my sleep too much to experiment.
Think I remember that leucine competes with tryptophan, could be reason.
 
bitterplacebo said:
Ever have trouble sleeping when taking xtend before bed?
I tried that once and felt like it took me much longer to fall asleep, but only ever done this one time because I like my sleep too much to experiment.
Think I remember that leucine competes with tryptophan, could be reason.
Click to expand...

You are correct, this is why it is beneficial pre workout. Anywho, I workout at night, but if I can't sleep it is generally because of Stims...
 
Okay, I dipped in the prize pack since this is taking so long to get to 1k.

So I will have two Xtend scoops + 1 D4 cap...
 
xjsynx said:
You are correct, this is why it is beneficial pre workout. Anywho, I workout at night, but if I can't sleep it is generally because of Stims...
Click to expand...

Never knew that, but makes perfect sense. Between the leucine and the citrulline, I always have a ton of energy during my WO or BJJ.
 
Plasma Ratio of Tryptophan:BCAA

5-hydroxytryptamine (5-HT) levels in the brain are believed to be a contributing factor to fatigue. Transport of the amino acid tryptophan, the precursor for 5-HT, across the blood brain barrier (BBB) is the rate limiting step in 5-HT synthesis. Therefore, increased plasma tryptophan levels can lead to fatigue. The Branch-Chained-Amino-Acids (BCAA) are transported across the BBB by the same carrier as tryptophan.
During exercise the plasma ratio of Tryptophan:BCAA increases (tryptophan increases and BCAA decreases), leading to fatigue.

The BCAA (leucine, isoleucine, and valine) are different from the other 17 amino acids in that they are primarily metabolized in skeletal muscle (Layman, 2003) and metabolized at a much lower rate in the liver (Norton, 2005). Studies show that BCAA ingestion during exercise delays fatigue due to limiting the amount of tryptophan that can cross the BBB (Bromstrand, 2006). In addition to dietary intervention, BCAA supplementation has been shown to spare muscle glycogen during exercise (Bromstand, 2006).

Little info on BCAA and Tryptophan from and article I wrote.
 
Rodja said:
Never knew that, but makes perfect sense. Between the leucine and the citrulline, I always have a ton of energy during my WO or BJJ.
Click to expand...

I found the article that referenced the study, which used BCAA's and not just Leucine...


Fatigued? With BCAAs, Not so Much

Fatigued? Have trouble recovering from workouts? Swedish researchers might have something for you.

Researchers examined whether branched-chain amino acids (BCAAs) played any role in reducing central fatigue. Fatigue comes in a couple flavors, namely peripheral and central. Peripheral fatigue is what you get in your biceps after trying a workout you found in FLEX where you do fifty sets of concentration curls and your arms don't work anymore.

Central fatigue is what you might feel after your first week training heavy with powerlifters... if you can still feel. Central fatigue (sometimes referred to as CNS fatigue) is typically described as a reduction in the neural drive (or nerve-based motor command) of working muscles. That results in reduced output, or strength. While mechanisms behind central fatigue are less well understood than those causing peripheral fatigue, changes in brain 5-hydroxytryptamine (5HT) is a likely suspect.

Now hang with me! With transport of tryptophan across the blood-brain barrier as the rate-limiting step in the synthesis of 5-HT, and transport of tryptophan influenced by the amount of tryptophan available for transport (as well as other large neutral aminos including the BCAAs), pumping subjects full of BCAAs would seem like an obvious first step to study.

Previous studies have shown the ratio of free (unbound) tryptophan to BCAAs increases with more tryptophan being sucked up by the brain during endurance exercise. This could suggest increased synthesis of 5-HT in the brain. By flooding the body with BCAAs and increasing BCAA concentration in plasma, the brain's uptake of tryptophan is reduced, or so the hypothesis goes. That should slow 5-HT synthesis and delay fatigue.

Sure enough, when human subjects were supplied with BCAAs during exercise (standardized cycle ergometer), ratings of perceived exertion and mental fatigue were reduced. Similarly, after a 30-km cross-country race, performance on different cognitive tests was shown to be improved following ingestion of BCAAs.

Researchers also noted this data suggested ingesting carbs during exercise could also reduce the brain's uptake of tryptophan and thus delay fatigue. Whatever the case, this is yet another reason to add some BCAAs to your nutritional toolbox. [J Nutr. 2006 Feb;136(2):544S-547S]
Click to expand...
 
Beast said:
Plasma Ratio of Tryptophan:BCAA

5-hydroxytryptamine (5-HT) levels in the brain are believed to be a contributing factor to fatigue. Transport of the amino acid tryptophan, the precursor for 5-HT, across the blood brain barrier (BBB) is the rate limiting step in 5-HT synthesis. Therefore, increased plasma tryptophan levels can lead to fatigue. The Branch-Chained-Amino-Acids (BCAA) are transported across the BBB by the same carrier as tryptophan.
During exercise the plasma ratio of Tryptophan:BCAA increases (tryptophan increases and BCAA decreases), leading to fatigue.

The BCAA (leucine, isoleucine, and valine) are different from the other 17 amino acids in that they are primarily metabolized in skeletal muscle (Layman, 2003) and metabolized at a much lower rate in the liver (Norton, 2005). Studies show that BCAA ingestion during exercise delays fatigue due to limiting the amount of tryptophan that can cross the BBB (Bromstrand, 2006). In addition to dietary intervention, BCAA supplementation has been shown to spare muscle glycogen during exercise (Bromstand, 2006).

Little info on BCAA and Tryptophan from and article I wrote.
Click to expand...


Good info, I just posted the same thing from an article I read. Do you have a link to this article you wrote?
 
My experience with Dialene 4 is it provides a very focused, mentally uplifting feeling. 2 caps provides a very smooth feeling while 3 caps puts you in the zone.
 
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