dsade
NutraPlanet Fanatic
Invalid Link Removed
Exclusively at the PLANET--Bulk Sesathin!
- Thread starter stryder
- Start date
dsade
NutraPlanet Fanatic
You got it.
In the end, its worth it though.
Beau
Well-known member
OK - I'll go first. I had NO IDEA. Can you elaborate, please?
Alpine
Active member
Uhm... seems like you are joking.
It was sort of a rhetorical question. I'm a fan of Sesathin ANYTIME. It just works. However, the cons of high dose sesathin use are removed when you use it on an anabolic. Then again, what isnt better on an anabolic? :lol:
Besides major fat loss, PPAR-gamma regulates the release of hGH, prolactin and Luteinizing Hormone (LH), this in turn effects Test production. Sesathin downregulates the release of LH slightly and production of testosterone can dip a bit. Obviously, its more pronounced in some than others. This often explains why some b1tch about libido loss on it. At standard to moderate dosages this is normally not an issue.
You cant have your cake and eat it too. For fat loss its still one of the best choices around. Just saying, Sesathin + anabolics + cal reduction + stims is about as good as it gets. Add in the fact that sesathin is great for the lipid profiles when "ON." Gotta keep it real at AM folx... I does it fo da childrenz.
Beau
Well-known member
Uhm... seems like you are joking.
I'm a fan of Sesathin ANYTIME. It just works. However, the cons of high dose sesathin use are removed when you use it on an anabolic. Then again, what isnt better on an anabolic?
Besides major fat loss, PPAR-gamma regulates the release of hGH, prolactin and Luteinizing Hormone (LH), this in turn effects Test production. Sesathin downregulates the release of LH slightly and production of testosterone can dip a bit. Obviously, its more pronounced in some than others. This often explains why some ***** about libido loss on it.
You cant have your cake and eat it too. For fat loss its still one of the best choices around. Just saying, Sesathin + anabolics + cal reduction + stims is about as good as it gets.
No, really. I've truly not studied much on SesaTHIN. It sounds like PHs and SesaTHIN compliment each other, not that they are synergistic. Is that correct?
Normally I joke a good bit - but I've not used SesaTHIN prior to this and didn't think about its implications other than weight loss.
OK - so much for my looking like anything other than a doofus.
Sir Savage
Board Sponsor
Uhm... seems like you are joking.
I'm a fan of Sesathin ANYTIME. It just works. However, the cons of high dose sesathin use are removed when you use it on an anabolic. Then again, what isnt better on an anabolic? :lol:
Besides major fat loss, PPAR-gamma regulates the release of hGH, prolactin and Luteinizing Hormone (LH), this in turn effects Test production. Sesathin downregulates the release of LH slightly and production of testosterone can dip a bit. Obviously, its more pronounced in some than others. This often explains why some b1tch about libido loss on it. At standard to moderate dosages this is normally not an issue.
You cant have your cake and eat it too. For fat loss its still one of the best choices around. Just saying, Sesathin + anabolics + cal reduction + stims is about as good as it gets. Add in the fact that sesathin is great for the lipid profiles when "ON." Gotta keep it real at AM folx... I does it fo da childrenz.
Well just a sec there, professor.
SesaThin activates PPARalpha, not PPARgamma.
No worries, though, my man. Easy mistake to make.
The libido effects that some guys experience are probably due mostly to SesaThin's anti-inflammatory effects, but there are probably a couple of other mechanisms involved, too.
The crazy thing is that I actually get better wood on SesaThin. Guess I'm weird like that.
Alpine
Active member
Hmmm...Well just a sec there, professor.
SesaThin activates PPARalpha, not PPARgamma.
No worries, though, my man. Easy mistake to make.
The libido effects that some guys experience are probably due mostly to SesaThin's anti-inflammatory effects, but there are probably a couple of other mechanisms involved, too.
The crazy thing is that I actually get better wood on SesaThin. Guess I'm weird like that.
So there is No LH/Test effect from Sesathin whatsoever? Libido loss was an often mentioned side it seemed. I did get mixed up, although that mechanism is correct for gamma. However, is it fair (or accurate) to say that sesathin does not effect alpha in ANY WAY? I keep seeing the both associated with it as im digging around. It is a more potent PPAR-alpha agonist, as well as being a potent anti-oxidant which leads to its superior anti-inflammation effects.
Sesamin increases gamma-tocephorol levels, and that is a PPAR-gamma AGONIST. Thus, we see PPAR-gamma antagonism, right? It's admittedly above my head at this point. Obviously, some mechanism exists. Libido loss with high dosage is fairly highly reported it seems. Flax seed lignans (like sesamine) are documented to decrease test levels slightly.
Are you suggesting all the anecdotal reports are completely erroneous? I dont place much value in them either. However, quite a few reputable users have mentioned this. I am by no means trying to bring down the glory of sesathin. It should be a staple for fat loss plans ON or OFF anabolics. There is a fine line between hype and misinformation though.
Sesamin is a lignan which in theory acts as an agonist at PPAR. Fibrates like bezafibrate show the same libido side effects.
I know there are actually a couple mechanisms by which sesathin could conceivably lead to this. It would be nice if you would take this opportunity to definitively clear it up for us. (see also: dont make me attempt it)
So perhaps I wasn't wrong after all? (Aside from saying gamma instead of alpha...) You just entered the no spin zone, and I ate my wheaties.
Sir Savage
Board Sponsor
No no, not calling their reports erroneous at all. It's a very real phenomenon for some guys, possibly due to enterolactone metabolite, etc.
I'm just pointing out that it's PPARalpha, not PPARgamma.
PPARgamma is no bueno for our purposes, for the very reason you went over and others.
I'm just pointing out that it's PPARalpha, not PPARgamma.
PPARgamma is no bueno for our purposes, for the very reason you went over and others.
Sir Savage
Board Sponsor
Ok real quick- probably the biggest reason for libido reduction is due to sesamin's actions on prostaglandins. Prostaglandins are responsible for a wide variety of actions in the body, including vasoconstriction.
Sesamin inhibits prostaglandins, which causes vasoconstriction, which can result in libido reduction.
Another possible contributing factor is sesamin's metabolite enterolactone, which is estrogen-like.
But I don't want anyone to freak out over this- you won't grow boobs or anything.
There are also maybe a couple of other possible contributing factors to the libido issue.
But a lot of guys don't even have libido issues on SesaThin, and even if you do, just take some AAKG or other "enhancer" for when the time comes.
Sesamin inhibits prostaglandins, which causes vasoconstriction, which can result in libido reduction.
Another possible contributing factor is sesamin's metabolite enterolactone, which is estrogen-like.
But I don't want anyone to freak out over this- you won't grow boobs or anything.
There are also maybe a couple of other possible contributing factors to the libido issue.
But a lot of guys don't even have libido issues on SesaThin, and even if you do, just take some AAKG or other "enhancer" for when the time comes.
Alpine
Active member
I understand you not wanting to get into the "possible scenarios" of how it could contribute to reduced libido. I appreciate your response anyway...
Lets just leave it at: Yes, some people have libido issues at high doses.
Back to the Sesathin Parade! :djparty:
Mulletsoldier
Binging on Pure ****ing Rage
PPARy abolishes insulin-induced Test., and estradiol production, stimulates Prog., and IGF-1 etc., this is true; however, is this common to the entire Gamma family? It would appear so, however all the studies I have examined have not specified if it was PPARy 1,2, or 3.
Sir Savage
Board Sponsor
I understand you not wanting to get into the "possible scenarios" of how it could contribute to reduced libido. I appreciate your response anyway...
Lets just leave it at: Yes, some people have libido issues at high doses.
Back to the Sesathin Parade! :djparty:
Well explaining the different possible mechanisms could get pretty exhaustive, plus it's been discussed on M & M, so for y'all that are curious, head on over and have at it.
And if you've got more questions, definitely bump those threads and ask. We're not ones to shy away from solid scientific discussion, as y'all know.
Sir Savage
Board Sponsor
Most likely 1 and 2, since they are the most expressed in key tissue like muscle, adipose, etc.
warnerve
Well-known member
it comes with a squirt nozzle. It's the same as a bottle of penetrate actually, at least what i got. If you really wanted to be a stickler for the right dosage, I would suggest an oral syringe personally, but I tend to be messy and sloppy as hell. Someone a little more careful would probably do fine.
Alpine
Active member
At this price, who needs to be "that" precise....
the more the better right? lol **** i have 8am's, im off to bed
yeahright
Well-known member
Squirt bottle. However, I just squirted mine into an oral syringe for accurate dosing. It was actually easier than pouring it from the container.
Mulletsoldier
Binging on Pure ****ing Rage
That's what I was thinking. I saw a study on the Pro12Ala polymorphism that showed no significant effect on serum oestrogen, oestradiol, andro., or test., levels though.
warnerve
Well-known member
At this price, who needs to be "that" precise....
**** i have 8am's, im off to bed
word, at this price you can afford to be liberal with the doses. Nutra should make a bulk sesamin, green tea caps, and ALA package..."The lean and healthy stack" I am gonna be using these three year round from now on
Bruth
Member
Naw I want the "Super Fat Cutting Stack" - Bulk Sesathin, Bulk XF, and Bulk Tonalin CLA
Blk98Bird
Member
Also, 1/4 tsp is almost exactly the right dose I believe. I use an old set of baking spoons we had around the house (which are cheap too) so that's another option
.
Alpine
Active member
Ya I wouldn't mind seeing some Tonalin....
dsade
NutraPlanet Fanatic
Actually, the bulk CLA softgels have just arrived, and we are waiting for lab tests to verify potency.
Imagine that.
Alpine
Active member
Yes, what a coincidence....some might call it eerie.
What are the ratios you were aiming for? C18:2 trans10, cis 12 isomer
Bruth
Member
Wow thats a quincidence I just posted that request in the "Request" thread.
dsade
NutraPlanet Fanatic
Yes, what a coincidence....some might call it eerie.
What are the ratios you were aiming for? C18:2 trans10, cis 12 isomer
Standard product breakdown (per 1 gram softgel) is as follows:
Conjugated Linoleic Acid (CLA) 700 MG:
Cis-9, Trans-11 Isomer 300 MG
Trans-10, Cis-12 Isomer 330 MG
We are trying to develop a trans 10, Cis 12 product that will be around 80% of the 70% (560mg of the CLA content). This will yield quite a potent product, since the 10,12 isomer is considered the biologically active isomer. Development is going slow, here.
LiftingFit
New member
Ordered me some bulk Sesathin! NutraPlanet is simply outstanding!
I'm a bit out of the loop regarding CLA though, as last I had read showed that what was available wasn't really that good. Got any links for some updated information? (Last time I checked into it was 2 or 3 years ago)
-Lifting
I'm a bit out of the loop regarding CLA though, as last I had read showed that what was available wasn't really that good. Got any links for some updated information? (Last time I checked into it was 2 or 3 years ago)
-Lifting
Alpine
Active member
Most CLA out there is garbage. Tonalin is pretty good stuff though. Sesathin is MUCH more cost effective. There arent as many studies but its relatively new in comparison.
I would estimate that Sesathin (combined with fish oil) works much better than CLA. And that is comparing HIGH dose CLA which will cost a lot. It needs to be good quality and the correct isomers too. Otherwise, you're wasting your time with CLA.
Personally, I lean toward sesathin on this one. If cost wasnt a factor, I would add high dose CLA with it.
Bruth
Member
How does this compare to other CLAs and other Tonalin CLA? And now a dumb question what is the difference between Tonalin and other CLA?
dsade
NutraPlanet Fanatic
The product we are bringing is is exactly the same as Tonalin.
Alpine
Active member
Tonalin is just a patented trade name for CLA. The reason it is good is becauase they have isolated the most desireable isomers, in good ratios, and its generally good quality. The avg. consumer is advised to look for this because at least they aren't buying junk.
"Our proprietary processing ensures the lowest levels of non-naturally occurring isomers (impurities) in our final product. When you choose TONALIN® CLA, you choose a one-of-a-kind, patented product uniquely consistent in purity and quality."
If Dsade can source a quality CLA with the active isomers (as he apparently has) and its processed decently, there is no reason for it to not be as good as Tonalin. The trick is finding a good source...
Tonalin is to CLA
as
Meg-3 is to Fish Oil
Jim Sadler
New member
CLA is weird. It's like it locks me in at a particular wieght, and regardless of diet I don't gain or lose. I remember I used it on a cruise vacation where every meal was a buffet and there wasn't much opportunity to exercise. I definitely think it helped me as a "damage control" product. Not so much of a help with getting leaner than I started out, or adding muscle.
As for the NP Sesathin... it's great. I've always responded well to this form of sesamin (less well with Scivation's, for some reason). At this price it's going to become a staple for me again.
As for the NP Sesathin... it's great. I've always responded well to this form of sesamin (less well with Scivation's, for some reason). At this price it's going to become a staple for me again.
rampage jackson
Registered User
soo....any chance in getting a bigger bottle than 8oz? I'm about 1/5 of the way through my 8oz...
dsade
NutraPlanet Fanatic
Alpine
Active member
lol :rofl:
TheMyth
RADIATE LOVER
Shoot, I would buy it! I would just gett all my fat cals from Sesathin! mmmmmm it tastes so good. But the texture is different than when I last bought it a few years ago, its now a clear oil, and before it was rather think and not see through. Any changes to it?
Alpine
Active member
What size are the bottles? 20mm?
Baxa Adapta-Caps and oral syringes.
Invalid Link Removed Invalid Link Removed
These are the 20mm size ones I have - hoping they fit...
yeahright
Well-known member
Hmmmmmmm. actually I've got some of those kicking around in my "supplement" box. I'll report back if it fits.
Alpine
Active member
yeahright
Well-known member
LOL, just tested it and it fits perfectly. Reps for the idea. I don't know what size my Adapt-a-cap is because nothing was marked on it. However, I'm using one from an old VPX prohormone bottle if that helps you with sizing.
Alpine
Active member
Pretty sure the VPX, Avant, and old IBE bottles were all 20mm. It's sort of like the standard size. Back when I was a younger kid, (before I got cut off
) I think I bought every supplement ever made...twice. 
dsade
NutraPlanet Fanatic
Can't we do both?
I am going to grab an oral syringe today, but I know just by squirting that it did not seem like 5ml to me either.
yeahright
Well-known member
I take it as a given that you're going to call me an idiot, that just doesn't get me to the answer of the question.
I put a full pump into a child's medicine measuring cup and it came out to exactly 2 ml per pump. It could just be a quirk in the mechanism of this specific pump but that's a hell of a mechanical variance (from 2 ml to 5 ml).
Using Alpine's suggestion, I've since retrofitted mine with an oral syringe and all is golden.
rockhard_4eva
Banned
I take it as a given that you're going to call me an idiot, that just doesn't get me to the answer of the question.
I put a full pump into a child's medicine measuring cup and it came out to exactly 2 ml per pump. It could just be a quirk in the mechanism of this specific pump but that's a hell of a mechanical variance (from 2 ml to 5 ml).
Using Alpine's suggestion, I've since retrofitted mine with an oral syringe and all is golden.
Same here, 2ml. I even mentioned it a while back, but I guess im not as important as you, so no ones cares.
