My take on IGF-1

OK Guys,

I have been using IGF for 8 days now and wanted to give you an update. I have first experimented with 30 mcg split bilaterally on the muscles just worked and on my first day chest (where I had shot earlier that day) was more tense than usual. I also had some tension in the forearms but not much else to report.

Also, as an aside, IMO, I think this stuff shouldn't be mixed with BW if you are using just one syringe and shooting bilaterally. In a tiny insulin syringe, IGF+AA and BW will simply not mix properly in my opinion. I may be off here and osmosis may ensure that the two substances mix but as far as I can tell, the surface tension of the liquid is too large for gravity to overcome it and the liquid to move freely in a tiny 1/3 cc insulin syringe. If you just pull a few ticks worth of IGF+AA and then also pull BW on top of it, even if there is a tiny bubble of air in between the two solutions, they do not mix. You can see this very clearly if you look. If there is no bubble, still there appears to be basically no movement and mingling of liquids at all. Hence, if you pull a couple ticks of IGF+AA and then some BW on top of it and shoot half the mixture in your left biceps first, and then shoot the remaining mixture in your right biceps, your right arm will receive most of the IGF and your left arm will get mostly just water. This is my opinion and observation based on the very little I know about fluid mechanics, I may be off so please chime in...

By the way, after I observed the above and started shooting just plain IGF+AA (instead of cutting it with BW right before injection) I realized the pain was very very minimal. Absolutely nothing to worry about. May there still be necrosis? I don't know...

Anyway, after pecs I continued to shoot into biceps and calves and overall I got some pretty weird effects from this product. First, the biceps and calves didn't really have much of a tension from IGF (unlike chest). Again, I was using dosages between 30 mcg and 60 mcg (I tried a different dosage everytime to experiment) and never went as high as 100 mcg as some people do. Also, FYI, I have shot IGF everyday since I started, including off days. The only day I didn't shoot was when I used MGF instead as per Grunt's suggestions.

However, unlike Sikboy who reported a general sense of well being on this, I experienced the oppostie and am feeling nervous as well as jumpy. First, the muscle tension is more around the jaw and temple area -strange because with many other CNS stimulants and stuff that gives you lots of tension, these were not areas where I had tension. Also, after I shoot IGF, I am having some stomach cramps. It is again a very starnge situation as I never had this kind of stomach cramp before. It is not a severe cramp but my stomach kind of "squeezes" if that makes sense. The pain is not local to one are of the stomach but the entire organ feels tight. Also, I get cravings much more often. Plus I have strange headaches lately.

Now, could all this be hypoglcemia? Very possible because I am cutting right now and even though I have shakes followed by a good meal PWO I am still in a small caloric deficit (around 400 kcal). I must tell you about a very strange trait of mine, however before you can interpret these results: I can lift with almost no CHO for quite a while before I crash. I have had situations -many times- where I ate ZERO calories for 24 hours and went straight into the gym to lift. Still I did the exact same weight and exact same reps. Also, i experience ZERO rebound hypoglycemia. I can eat 200 grams of fructose or 200 grams of pure dextrose with nothing to slow absorption and feel nothing, absolutely nothing. As a teen, I ate 8-9 candy bars in an hour on multiple occasions and then, too, even at a weight of 140 lbs felt nothing. (I know these are not good ideas and there is long story behind each of these stunts...). So maybe I am going hypo but my symptoms are different due to my unusual biochemistry.

This is my story thus far. I will have quesitons soon but for now I wanted to thrown these in there.
 
in regards to media grade vs receptor grade igf. Would you keep the dosage the same for receptor as you would for the media grade? i.e. 40mcg bi lat 3x's a week in my case?

thanks...
 
Also, as an aside, IMO, I think this stuff shouldn't be mixed with BW if you are using just one syringe and shooting bilaterally. In a tiny insulin syringe, IGF+AA and BW will simply not mix properly in my opinion. I may be off here and osmosis may ensure that the two substances mix but as far as I can tell, the surface tension of the liquid is too large for gravity to overcome it and the liquid to move freely in a tiny 1/3 cc insulin syringe. If you just pull a few ticks worth of IGF+AA and then also pull BW on top of it, even if there is a tiny bubble of air in between the two solutions, they do not mix. You can see this very clearly if you look. If there is no bubble, still there appears to be basically no movement and mingling of liquids at all. Hence, if you pull a couple ticks of IGF+AA and then some BW on top of it and shoot half the mixture in your left biceps first, and then shoot the remaining mixture in your right biceps, your right arm will receive most of the IGF and your left arm will get mostly just water. This is my opinion and observation based on the very little I know about fluid mechanics, I may be off so please chime in...
You are way off bro. It isn't a complex thing: when drawing the BW into the barrel that has AA/IGF in it, the BW jets into the solution, even if you draw relatively slowly. This ensures a perfectly uniform mixture. If you don't believe me, just cut your IGF/AA with some B12 instead. It's red. You end up with a perfectly uniformly pink solution.

in regards to media grade vs receptor grade igf. Would you keep the dosage the same for receptor as you would for the media grade? i.e. 40mcg bi lat 3x's a week in my case?

thanks...
Nope, I would reduce it in half and see. You may get the same effects with 20mcg receptor as you do with 40mcg media, but not twice the effects with 40mcg receptor as you do with 40mcg media. There is a fairly low saturation point IMO.
 
You are way off bro. It isn't a complex thing: when drawing the BW into the barrel that has AA/IGF in it, the BW jets into the solution, even if you draw relatively slowly. This ensures a perfectly uniform mixture. If you don't believe me, just cut your IGF/AA with some B12 instead. It's red. You end up with a perfectly uniformly pink solution.

I hope I didn't mislead anyone -obviously Grunt has done many many more experiments with this than I did, so I must have misinterpreted what happened. Just one observation I would like to repeat: do not leave too big an air bubble between IGF/AA and BW...

any comments about the rest of the stuff I reported such as the stomach cramps, aggitation etc...?

Thanks
 
Question for Grunt, a bit off topic...

Do you know if ghrelin is ok mixed with BW, or should it be done with AA like IGF is??

I just got some ghrelin and all they sent with it was BW, it doesn't seem to work the same way now (a week later) as the first shot did. I am keeping it in the fridge also.
 
Question for Grunt, a bit off topic...

Do you know if ghrelin is ok mixed with BW, or should it be done with AA like IGF is??

I just got some ghrelin and all they sent with it was BW, it doesn't seem to work the same way now (a week later) as the first shot did. I am keeping it in the fridge also.

Nope, BW is the way to do it. It is a new peptide so we all have to learn how to work with it. Maybe make a new thread about it bro, lots of people are going to want to know about it.
 
I posted a bunch of questions in the "Ghrelin 101" thread but didn't get much response.

When I figure something out with this stuff, I post it up. Still experimenting with dose and IM or sub-q right now.

Thanks Grunt!
 
Grunt do you recommend ceasing IGF usage on a stack similar to what you are running now? I'm doing the same stack and dropped the IGF due to the likely lower estrogen levels and the IGF losing its effectivity.
 
Sub7,
I too thought about that when I first started but Grunt told me what he told you. You can tell that it really does jetstream into the syringe. If you are worried about there not being a uniform mixture, try pinning left side first on one day and then right side first on the other.

Also, about BW, its not just there for the necrosis. It also ensures that the igf-1 is spread around more surface area on the muscle.

Also, sikboy was running 2 grams of gear on top of the igf-1. I think this somewhat skews the results...ofcourse he had a good sense of wellbeing on that much test.

As for the stomach pains, its hunger/hypoglycemia. I get super hungry on the ****
 
Grunt do you recommend ceasing IGF usage on a stack similar to what you are running now? I'm doing the same stack and dropped the IGF due to the likely lower estrogen levels and the IGF losing its effectivity.

Yes it would be a great stack with IGF-1.

Lower estrogen lowers IGF-1 _expression_ by estrogen-dependent tissue. It does not lower IGF-1 effectiveness.
 
^^^Thanks
 
steriods4life... No source posting.

For some reason I picture you riding a BMX with a beer helmet... not that there is anything wrong with that.
 
Sorry Gentlemen, can someone compare the efficacy of the Oratotropin product to injectable IGF LR3?

I am looking at "1200mcg Cell-Mediated™ IGF-1" (drinkable) and was just wondering how potent this would be compared to, let's say, 40 mcg of IGF LR3. I know there is no magic conversion factor but still wanted to hear from the experts...

Also, if "1200mcg Cell-Mediated™ IGF-1" comes in one vial, I assume you'd drink the whole thing at once after opening the vial right?

Thanks Gents...
 
Sorry Gentlemen, can someone compare the efficacy of the Oratotropin product to injectable IGF LR3?

I am looking at "1200mcg Cell-Mediated™ IGF-1" (drinkable) and was just wondering how potent this would be compared to, let's say, 40 mcg of IGF LR3. I know there is no magic conversion factor but still wanted to hear from the experts...

Also, if "1200mcg Cell-Mediated™ IGF-1" comes in one vial, I assume you'd drink the whole thing at once after opening the vial right?

Thanks Gents...
No, it is in 15 separate syringes. Mcg for mcg they are both about equal in efficacy.
 
stupid misunderstanding on my part: how can there be 1,200 mcg in one single vial...

about the same eficacy per mg of the injectanble vs oral version; so you are saying oratotropin has basically 100% oral availability?
 
I assume you'd drink the whole thing at once after opening the vial right?

Definitely do NOT drink it. It's meant to absorb through the membranes in your mouth. If you just swallow it, it will not absorb in the stomach. Just put it in your mouth in between the cheek and the gum, and let it sit there for 15-30 minutes before swallowing. (This is easiest if you just lie on your side so the fluid rests on your cheek.)
 
stupid misunderstanding on my part: how can there be 1,200 mcg in one single vial...

about the same eficacy per mg of the injectanble vs oral version; so you are saying oratotropin has basically 100% oral availability?

Yes because it is in a special preparation that allows it to be absorbed through the walls of the mouth. It never goes into the digestive system... Straight from your mouth to your lymphatic system.
 
OK gents, got it. Thank you so much for all the wonderful information in this thread and answering all questions so dilligently...

Sub
 
As per your advice Gentlemen, I have mixed the IGF+AA solution with BW this time. I used the same dose as i had done over the last 15 days and this time, right before I injected the solution into the biceps, i mixed it with BW (I used as much BW as the amount f IGF+AA solution and mixed the BW only 20-30 seconds before injection).

Even though I always had slight cramps following biceps injections, this time I felt nothing. Good, bad, doesn't mean anything? Also the hunger wasn't there. Strange isn't it? I know this is just one single trial with BW but I believe it wasn't placebo...
 
will be beginning 100mcg of IGF-1 postworkout, shot like this

20mcg upon waking(subq)

20mcg 4x(bilat, each musclegrouping)

Lots of pinning, have experience with PGF2A so im ok with the pain. Keep everyone posted, 2nd time using IGF-1. Have ran in the past at 60mcg every day, wasnt that impressed
 
will be beginning 100mcg of IGF-1 postworkout, shot like this

20mcg upon waking(subq)

20mcg 4x(bilat, each musclegrouping)

Lots of pinning, have experience with PGF2A so im ok with the pain. Keep everyone posted, 2nd time using IGF-1. Have ran in the past at 60mcg every day, wasnt that impressed

Did you read this thread?
 
Yeah whenever I see a 21-year-old with PGF2a experience who was not impressed with 60mcg of IGF-1, I can't help but think that he must be a true monster.

Or, wait, someone who doesn't even have the basics covered.
 
i changed sources, i think something was up with my igf-1 lasttime. No need for the insults, have only had 2 2wk runs of PGF2A. Pinned 4x daily at 2.5mg a shot, loved the results.. hated the sides, too much to take. Ran the igf-1, i have the basics long covered

I read the whole thread, ive read it on all boards its been posted on. Its just hearsay, sure could be true and great. But could be totally wrong, ive seen IGF-1 ran at 400mcg daily alongside a burst 30day cycle. The guy gained 11kg, thats ~25lbs. I see no evidence that beyond 60-80mcg is "wasted", could be just like gear.. adrogen receptors upregulate in high dosages, i see no evidence. Just lots of opinions, also grunt you have a pretty sloppy build to say the least. For someone whose tried so many compounds, with so much knowledge id say you dont "have the basics covered".

How much igf-1 do you think the pros take? To get the abdominal growth they recieve, there dozens of threads around of people running up to around 120mcg daily. They suffer no VISIBLE stomach growth, even many months later. Money is the reason nobodys dosing above 200mcg daily, but i can gaurantee its done. Even if for only a week/10 days at a time due to saturation
 
(Done in the "MOVIE GUY" voice)

In a world... of ridiculous conjecture and flatulent opinions from a French Canadian, a man stands alone. Come forth to right the wrongs where others fell short... stvn, This time... It's for real.

This moron is not yet rated. :clap2:
 
Thanks, Grunt

I personally appreciate all that you have done to share your knowledge, Grunt. From all the reading I have done, what you have said makes the most sense.
 
grunt I really appreciate the info you have provided here and it has really helped me in regards to my IGF usage.

I was wondering if you recomend dosing the IGF differently in regards to injury recouperation? I just seperated my clavical from the chest plate yesterday(snowboarding not training) and have some tendon tearing as a result. We got it back in place today and the doctor gives me 6 weeks to slowly work my way back into training. He says IGF would usefull in my recovery, injected into the nearby muscle tissue. He is an athlete as well and is aware of what it is i'm doing.

In this type of situation would it make sense to do a 3 week cycle of 25-25mcg 2xtimes daily? or something similiar, or just stick with 40-50mcg EOD?
 
Grunt must ask you ! are on igf-1 and peg-mgf now 50 mcg igf-1 receptor grade.
Peg-mgf 300 mcg/week 2 times per week
and my stomach is very bloated and can"t eat so much my apitite is all gone and must have much food in me now !
Have you heard about somebodyells that had this problem? and what to do?
 
grunt I really appreciate the info you have provided here and it has really helped me in regards to my IGF usage.

I was wondering if you recomend dosing the IGF differently in regards to injury recouperation? I just seperated my clavical from the chest plate yesterday(snowboarding not training) and have some tendon tearing as a result. We got it back in place today and the doctor gives me 6 weeks to slowly work my way back into training. He says IGF would usefull in my recovery, injected into the nearby muscle tissue. He is an athlete as well and is aware of what it is i'm doing.

In this type of situation would it make sense to do a 3 week cycle of 25-25mcg 2xtimes daily? or something similiar, or just stick with 40-50mcg EOD?
I agree with your twice a day 3 x week idea. That would work very well IMO. And dude, I need to find a doc just like yours.


Grunt must ask you ! are on igf-1 and peg-mgf now 50 mcg igf-1 receptor grade.
Peg-mgf 300 mcg/week 2 times per week
and my stomach is very bloated and can"t eat so much my apitite is all gone and must have much food in me now !
Have you heard about somebodyells that had this problem? and what to do?
How much do you weigh? Are you using 300mcg a week of pMGF or 600? 150mcg twice a week, right?
 
Grunt I came across an article regarding IGF. The author discusses its benefits but then goes on to these thoughts by Mauro Di Pasquale, MD,

"There is a feedback mechanism between the human growth hormone in the pituitary gland and the IGF-1 in the liver. The human growth hormone stimulates the release of IGF-1, but when the levels of IGF-1 rise to a certain point in the circulation, it signals the shutdown of growth hormone."

1. In your opinion is this accurate?
2.What can be done to minimize this?
3. Can CJC at help kick start the HGH natural production?

Thanks
 
iam around 110kg pretty lean! yes using 300 mcg per week
heard of something like that?

That is a small amount. No, I have never heard of such happenstances.

Grunt I came across an article regarding IGF. The author discusses its benefits but then goes on to these thoughts by Mauro Di Pasquale, MD,

"There is a feedback mechanism between the human growth hormone in the pituitary gland and the IGF-1 in the liver. The human growth hormone stimulates the release of IGF-1, but when the levels of IGF-1 rise to a certain point in the circulation, it signals the shutdown of growth hormone."

1. In your opinion is this accurate?
2.What can be done to minimize this?
3. Can CJC at help kick start the HGH natural production?

Thanks
1. Yes. I highly respect Dr. Mauro DiPasquale and his work.
2. Stack GH with your IGF-1. :)
3. Yes, and so can GHRP-6 and hexarelin. :hammer:
 
yes but I respone extreme on igf-1 had done it before on 40 mcg media grade and extreme results! hoping it will get better :woohoo:

That is a small amount. No, I have never heard of such happenstances.


1. Yes. I highly respect Dr. Mauro DiPasquale and his work.
2. Stack GH with your IGF-1. :)
3. Yes, and so can GHRP-6 and hexarelin. :hammer:
 
Also, do you think the recomp/fatloss properties of GH are primarily due to its effects on IGF and MGF? In this case, should IGF+MGF be expected to have similar fatloss properties? Or is this GH effect caused through some other mechanism?
 
If you do this though, aren't you reintroducing the "GH gut" problem that you're trying to avoid with your IGF protocol in the first place? (Not to mention spending lots of $$$.)
No, the GH gut problem only happens at high doses of GH stacked with insulin. Dosing IGF-1 ensures that insulin stays low.

Also, do you think the recomp/fatloss properties of GH are primarily due to its effects on IGF and MGF? In this case, should IGF+MGF be expected to have similar fatloss properties? Or is this GH effect caused through some other mechanism?
GH has its own mechanism quite separate from IGF/MGF. One particularly important piece of evidence of this is the controversial "GH Fragment" which can elicit fatloss on its own, and in fairly dramatic amounts in some people.

I attribute IGF-1's fatloss prowess to a few things:

1. Low insulin. IGF-1 replaces insulin for a few hours but only shuttles nutrients to non-fat cells. This allows for lipolisys to continue even when lots of high GI carbs are ingested, a condition in which normally insulin rises and puts a stop to lipolysis.

2. Shuttling nutrients to only lean cells. That is obvious but it is a point on its own.

3. Hyperplasia consumes LOTS of energy! Proliferation of myoblasts also. This is slower energy consumption is suited to fat metabolism.
 
As far the anti-aging properties of GH goes, is it the IGF-1 that helps with this or another property of GH that does??

I'm asking because my wife is 38 and the little wrinkles are starting to bug her. We've talked about GH before, but if we could go straight to the IGF, that would be mch easier.

Also Grunt...would a woman's dosage be about 1/2 of a guys? She does lift pretty hard and eats cleaner than I do. She'd like a little more muscle, but other than that, she's pretty happy with her body.
 
As far the anti-aging properties of GH goes, is it the IGF-1 that helps with this or another property of GH that does??

I'm asking because my wife is 38 and the little wrinkles are starting to bug her. We've talked about GH before, but if we could go straight to the IGF, that would be mch easier.

Also Grunt...would a woman's dosage be about 1/2 of a guys? She does lift pretty hard and eats cleaner than I do. She'd like a little more muscle, but other than that, she's pretty happy with her body.

I believe that SOME of the anti-aging properties of GH are mediated through IGF-1 but, really, for anti-aging, nothing beats GH. Dosage should be equal to a male, but proportional to bodyweight. IOW a 150lb female would use as much GH as a 150lb male. Start low and work your way up, but for pure anti-aging, 2 x 1.5iu ED would be plenty.
 
I believe that SOME of the anti-aging properties of GH are mediated through IGF-1 but, really, for anti-aging, nothing beats GH. Dosage should be equal to a male, but proportional to bodyweight. IOW a 150lb female would use as much GH as a 150lb male. Start low and work your way up, but for pure anti-aging, 2 x 1.5iu ED would be plenty.

Got it, thanks Grunt!
 
Grunt,

I have a buddy of mine who won't touch igf because of the fear of the "gut effect" What type of dosage would you need in order for that to happen with igf??
 
Grunt,

I have a buddy of mine who won't touch igf because of the fear of the "gut effect" What type of dosage would you need in order for that to happen with igf??

That's been discussed quite a bit in this thread. Keep it under 40 mcg every three days and he should be fine.
 
Grunt,

I have a buddy of mine who won't touch igf because of the fear of the "gut effect" What type of dosage would you need in order for that to happen with igf??

100mcg ED is a good start. If that doesn't work, then 200mcg ED should help. :lol:
 
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