zaareleq
Member
Same
SLU-PP-332 FAQ.
- Thread starter brundel
- Start date
brundel
Board Sponsor
We havnt sent out emails yet. Need to make sure we have stock of everything first. The list will likely only have the most in demand items first but will eventually have tons of chemicals available including things like cyclodextrins and glassware, scales, microscopes etc.
brundel
Board Sponsor
You guys ever hear of orforglipron? Interesting stuff. Have also been looking at some really interesting studies that are utilizing permeation enhancers and PH agents to deliver peptides orally. Even insulin and GH and other things. Pretty crazy, considering not long ago this was considered impossible. Like real Oral peptides. Opens the door for all kinds of things.
Gonna give my
some orforglipron and see if it works well.
Gonna give my
some orforglipron and see if it works well.THEstudent
Member
Yeah Jay Campbell and Hunter Williams were the first I heard mention it. They seem really impressed with it, so much so they recently put it out in their product line.You guys ever hear of orforglipron? Interesting stuff. Have also been looking at some really interesting studies that are utilizing permeation enhancers and PH agents to deliver peptides orally. Even insulin and GH and other things. Pretty crazy, considering not long ago this was considered impossible. Like real Oral peptides. Opens the door for all kinds of things.
Gonna give my
botk1161
Well-known member
I think someone did earlier in this thread.
brundel
Board Sponsor
There is a post up on our ig with over 300 comments. Most of the comments are positive reviews. 0 negative reviews.
HTGduck
Active member
I've been on these forums since 2014 and BLR and Brundel have always been extremely well respected and regarded.
botk1161
Well-known member
Do some homework before being a lazy dick. BLR has never put out a product that does not provide good results. If you did your homework, you would know that. Bodybuilding.com is better suited for you.
Renew1
Legend
If you haven't already posted your blood work, please do so, for the benefit of others.
zaareleq
Member
Either way you've been given answers here as to people's experience and opinion on BLR. You were directed to reviews on Reddit. There are reviews in this thread. You yourself said you don't trust COA's. Outside of reviews and / or COA's what type of info would you expect to gain?? It's on you to take that info and make your own decision. It does no good for you to be a confrontational ass here. Either buy it or don't
JKVol
Well-known member
Is this up yet?
brundel
Board Sponsor
Website took a bit longer than expected. Its an FN nightmare trying to find payment processing for this sort of thing these days. I also wanted to wait until we had enough stuff in stock. We will probably open shop to the public via email in the next week or so. The website will probably be mid NOV or third quarter NOV.
We will also have scales, Beakers, Hotplates and all kinds of research chemistry related products available for those who work in the field.
brundel
Board Sponsor
There isnt alot of data regarding slu but some report this. Considering it is an exercise mimetic this makes sense.
Ff129
New member
Use mitochrondria assisting supps coq10 , urolithin a, Ala
Ff129
New member
Helps redox
brundel
Board Sponsor
Yah I have read that due to increased mitochondrial respiration and Krebs cycle activity you may want to include certain things like Glutathione, COq10 and some others. Ill dig into it more. But, without additional support its like overclocking a computer or running a toyota civic on jet fuel. Eventually something else suffers.
Nprice151
Member
How has this been treating your rat?You guys ever hear of orforglipron? Interesting stuff. Have also been looking at some really interesting studies that are utilizing permeation enhancers and PH agents to deliver peptides orally. Even insulin and GH and other things. Pretty crazy, considering not long ago this was considered impossible. Like real Oral peptides. Opens the door for all kinds of things.
Gonna give my
HTGduck
Active member
I'm curious as well because needles are absolutely repulsive to me lol
brundel
Board Sponsor
I havnt had a chance to test it. Things are nuts.
New brand coming in ....maybe 10 days I would think. Website is done with the initial construction phase and we are just getting everything setup for payment (no small feat these days) and uploading all the product descriptions, COAs etc (also no small feat)
Whats interesting is I heard from a little bird that some companies will offer oral versions of some products.
Intranasals, topicals, and all kinds of interesting stuff.
Did you know that T I R Z can be made into an oral? And 2 weeks in it results in higher serum levels than injectables!? The only downside is its massively more expensive because you have to take 3mg a day vs a week.
THEstudent
Member
Wonder can tesamorelin be made into an oral?
brundel
Board Sponsor
Im not certain, ill have to look. But ipamorelin and cjc can. In fact ive got some. The technology is interesting.
Shadowblaze
Active member
What about something like hcg?
Do you ever plan on releasing something like those products for research purposes?
brundel
Board Sponsor
Yes for research purposes. There will be all kinds of things available for research.
Lots of things normally not available. Nothing controlled of course but novel administration methods and carriers etc. We want to offer things for new types of research and alot of the new studies are aimed at administering peptides and others in different ways.
Lots of things normally not available. Nothing controlled of course but novel administration methods and carriers etc. We want to offer things for new types of research and alot of the new studies are aimed at administering peptides and others in different ways.
GNXClone
New member
Recently saw a vendor offering SLU in a liquid oral at 100mg (yes, milligrams) per ml, 30ml bottle, so 3 grams, for $120. That's a great price when compared to most. I've seen raw powders priced higher per gram.
I'm torn on getting it though because so far I have tried 250mcg, 500mcg, 1mg and even 40mg per dose and I never "feel" anything. Yet I am constantly seeing people raving about how great it is.
How do you tell if it's really working? Fat loss? I was in a deficit and taking reta, so can't use that as a gauge. I also take GW and armodafinil and caffeine / ephedra, so can't use energy as a gauge either.
I'm torn on getting it though because so far I have tried 250mcg, 500mcg, 1mg and even 40mg per dose and I never "feel" anything. Yet I am constantly seeing people raving about how great it is.
How do you tell if it's really working? Fat loss? I was in a deficit and taking reta, so can't use that as a gauge. I also take GW and armodafinil and caffeine / ephedra, so can't use energy as a gauge either.
HTGduck
Active member
Sounds like you are probably on enough substances boss man. At that point it would be impossible to point out benefits of each particular one
brundel
Board Sponsor
Slu in a liquid would no longer be slu by the time you received the package. It starts degrading within 24-48 hours max in solution. This is stored at like -4c.
Since it would have to be made ahead of time and stored most likely on a room temperature shelf or box followed by shipping, this means it would almost certainly be inert by the time you got it. This is why we do sublingual tabs. That and the fact that oral administration is poor at best.
The scientists who developed it are working on an oral version. Why would they spend the time and money to work on an oral version if it worked orally?
Finally, if someone is selling you 3g for 120$ its almost certainly fake. If not for the fact that they could sell that 3g for 6000-12000$.
Seems legit.
Since it would have to be made ahead of time and stored most likely on a room temperature shelf or box followed by shipping, this means it would almost certainly be inert by the time you got it. This is why we do sublingual tabs. That and the fact that oral administration is poor at best.
The scientists who developed it are working on an oral version. Why would they spend the time and money to work on an oral version if it worked orally?
Finally, if someone is selling you 3g for 120$ its almost certainly fake. If not for the fact that they could sell that 3g for 6000-12000$.
Seems legit.
mozwilde
New member
HView attachment 252768
SLU-PP-332
SLU-PP-332 is a small molecule that acts as a potent, non-selective agonist of estrogen-related receptors (ERRs), particularly ERRα. Developed at Saint Louis University School of Medicine, it has garnered attention for its potential applications in metabolic health, exercise mimetics, and...blacklionresearch.com
SLU-PP-332: A (relatively) Comprehensive Overview
SLU-PP-332 is a small molecule that acts as a potent, non-selective agonist of estrogen-related receptors (ERRs), particularly ERRα. Developed at Saint Louis University School of Medicine, it has garnered attention for its potential applications in metabolic health, exercise mimetics, and bodybuilding.
Mechanism of Action
As an ERRα agonist, SLU-PP-332 enhances mitochondrial activity and energy metabolism. It binds to the ERRα receptor, stabilizing its active conformation and enhancing its interaction with coactivator proteins, particularly PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha). This activation leads to:
- Upregulation of mitochondrial biogenesis through increased expression of TFAM (mitochondrial transcription factor A).
-Enhanced expression of genes involved in oxidative phosphorylation (OXPHOS).
-Increased fatty acid uptake and β-oxidation through regulation of CPT1 (carnitine palmitoyltransferase 1) and MCAD (medium- chain acyl-CoA dehydrogenase).
-Stimulation of AMPK (AMP-activated protein kinase) signaling, mimicking energy-deprived cellular states.
These effects collectively improve cellular energy production, fat oxidation, and overall metabolic efficiency.
Pharmacology and Pharmacokinetics
Absorption: Oral bioavailability has not been established. In fact studies indicate it will need to be altered to allow for oral administration vs injection or IP administration. Here is a quote from a relevant study= "The next step is to improve its structure and make it into a medication candidate, ideally so that it may be given as a tablet rather than an injection"
There is no evidence this can be administered orally and while lots of companies seem to be selling oral capsules the chance is high that these are either completely fake and lacking SLUpp332 or inert as MCG doses orally are likely not viable orally. In addition it appears that SLUPP332 degrades quickly in solution. Multiple sources indicate that even when stored at -80c it may be viable for several months while at -20c it remains viable for about 30 days. At room temperature it degrades rapidly within around 48 hours. This means that a liquid oral would be inert by the time it reached any customer. As a result Black Lion Research has developed a sublingual version as this compound is a prime candidate for subulingual administration. This means that our sublingual tablets are likely the only viable option presently available.
Distribution: Widely distributed to metabolically active tissues including liver, skeletal muscle, and adipose tissue, with high mitochondrial tropism.
Metabolism: Primarily metabolized by hepatic CYP450 enzymes, with phase II glucuronidation as a secondary pathway.
Elimination: Predominantly excreted via biliary/fecal routes with a plasma half-life of approximately 8-10 hours in rodents.
Blood-Brain Barrier: Limited penetration across the blood-brain barrier (<5% of plasma levels).
Benefits
1. Exercise Mimetic Effects
SLU-PP-332 mimics the physiological effects of exercise, providing benefits such as:
Increased mitochondrial density in skeletal muscle.
Enhanced expression of GLUT4 glucose transporters in muscle tissue.
Improved muscular endurance and running capacity.
Reprogramming of muscle fiber type composition toward more oxidative phenotypes.
Increased vascular density in skeletal muscle.
Enhanced cardiac efficiency through improved mitochondrial function.
In another paper published in March, the researchers reported that they had observed that the compound allowed normal-weight mice to run for 70% longer and 45% further than mice not receiving SLU-PP-332.
2. Fat Loss and Metabolic Health
Studies in animal models have shown that SLU-PP-332 improves insulin sensitivity and reduces adiposity, while anecdotal evidence shows that SLU-PP-332 is exceptional as a fat loss agent. When administered to diet-induced obese mice, SLU-PP-332 produced:
18-24% reduction in body weight.
30-35% decrease in white adipose tissue mass.
40% improvement in glucose tolerance.
25-30% decrease in fasting insulin levels.
Significant reduction in hepatic steatosis and inflammation.
3. Mitochondrial Health and Aging
SLU-PP-332 has been studied for its role in reversing mitochondrial dysfunction and inflammation in aging tissues. In aged rodent models, SLU-PP-332 demonstrated:
Restoration of mitochondrial respiration rates in kidney and liver tissues.
Reduction in age-associated inflammation markers (IL-6, TNF-α).
Decreased oxidative damage to mitochondrial DNA.
Improved autophagy and mitophagy.
Attenuation of fibrotic tissue changes in kidneys and heart.
4. Muscle Mass Maintenance:
It may help preserve muscle mass during weight loss or aging, which are situations where muscle loss is a concern.
Improved insulin sensitivity.
Improved Muscle mitochondrial function.
Improved endurance.
5. Cardioprotective Effects:
Preservation of Cardiac Contractility: SLU-PP-332 has shown promise in preserving heart function after ischemic events (reduced blood flow to the heart).
Reduced Cardiomyocyte Apoptosis: It can help prevent the death of heart muscle cells.
Improved Myocardial Energetics: The compound enhances fatty acid oxidation in the heart, leading to improved energy production.
SLU-PP-332 has demonstrated the ability to improve heart function in animal models of heart failure by enhancing fatty acid oxidation and mitochondrial metabolism. It can also reduce fibrosis in the heart.
Research and Applications
SLU-PP-332 has been tested in several pre clinical studies, including its ability to:
Improve metabolic syndrome by enhancing mitochondrial efficiency.
Induce exercise-mimetic effects in muscle tissue.
Reverse age-related mitochondrial dysfunction.
Current development status includes advanced toxicology studies in multiple species, with safety profiles generally well-tolerated in rodent and canine models at therapeutic doses. Oral and Extended-release formulations are under development to optimize pharmacokinetics. SLU-PP-332 has been tested up to 1000mg in rodent models.
mozwilde
New member
They have a very sweet taste to them. Like they're sugar pills. Is that normal?
botk1161
Well-known member
Yes
Mark David
New member
Nope. Never "felt" anything after taking it. Think it's a cumulative effect from what Ive read/listened to.
Believe that if you feel something after taking it, it probably isn't the SLUPP