sns8778
Board Sponsor
The plan was to do 90 Veg Caps per bottle with each containing Kava (std. to 30% Kavalactones) - 375 mg. per capsule so that would equal 112.5 mg. Kavalactones per capsule.
SNS - Nootropic Request Thread - Tell Us What You Want
- Thread starter sns8778
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The plan was to do 90 Veg Caps per bottle with each containing Kava (std. to 30% Kavalactones) - 375 mg. per capsule so that would equal 112.5 mg. Kavalactones per capsule.
scump
Member
I'm keen for an all in 1 capsule, preferably where a serving size is 2 caps or less.
IDK about everyone else but the amount of powders/caps taken each day gets excessive. esp when you consider joint support alone is usually like 4 caps a day.
I used to use Nootropimax by performax labs and really enjoyed it, effective formula and even only 1 cap worked great.
I liked focus XT but haven't used it in several years bc i don't really feel like chugging down something at 5am and chancing the squirts early at work. Also i like the idea of stim free focus supps too, makes stacking much more friendly.
IDK about everyone else but the amount of powders/caps taken each day gets excessive. esp when you consider joint support alone is usually like 4 caps a day.
I used to use Nootropimax by performax labs and really enjoyed it, effective formula and even only 1 cap worked great.
I liked focus XT but haven't used it in several years bc i don't really feel like chugging down something at 5am and chancing the squirts early at work. Also i like the idea of stim free focus supps too, makes stacking much more friendly.
sns8778
Board Sponsor
The max volume in a size 00 capsule is 750 to 800 mg; so that would make 2 caps be 1500 to 1600 mg. So the amount of capsules is really dictated by the amount of active ingredients which can then limit what you can use in the product.
Nootropimax had had Noopept in there and many retailers will not carry Noopept anymore so its not something we would use in a combination product for that reason.
If you haven't tried the newest version of Focus XT that's been out for the last few years, you should give it a try. We also do make a Caffeine Free version.
Later this year, we do have more than one nootropic capsule products coming out but its too soon for an ETA as we have a lot of things in production in front of it.
poison
Board Sponsor
Damn, nice. I love kava. Is this from roots only? Would you consider doing a powdered root powder, not capped?
Nitrosigine would be great, I've been taking it frequently, and like it a lot.
How about a 1-2 cap multi-ingredient nootropic for use with morning coffee? Plenty of decent formulas out there, but few without caffeine, and I ain't giving up my morning coffee for anything.
Also, in any formula you do, **** l-theanine, unless it's a sleep formula.
jarrellt67
Well-known member
I'll strongly second a nootropic formula and especially one without l-theanine.Damn, nice. I love kava. Is this from roots only? Would you consider doing a powdered root powder, not capped?
Nitrosigine would be great, I've been taking it frequently, and like it a lot.
How about a 1-2 cap multi-ingredient nootropic for use with morning coffee? Plenty of decent formulas out there, but few without caffeine, and I ain't giving up my morning coffee for anything.
Also, in any formula you do, **** l-theanine, unless it's a sleep formula.
sns8778
Board Sponsor
We are working on a couple of different nootropics but its such a broad category to appeal to everyone. I'd be curious to see what ingredient ideas you'd like to see in one.
As for Theanine, it seems to be very disliked by some here but its one of the most researched and best selling nootropic ingredients on the market so it puts companies in a tough spot sometimes.
sns8778
Board Sponsor
Damn, nice. I love kava. Is this from roots only? Would you consider doing a powdered root powder, not capped?
Nitrosigine would be great, I've been taking it frequently, and like it a lot.
How about a 1-2 cap multi-ingredient nootropic for use with morning coffee? Plenty of decent formulas out there, but few without caffeine, and I ain't giving up my morning coffee for anything.
Also, in any formula you do, **** l-theanine, unless it's a sleep formula.
Yes, it is from Kava Root only.
I doubt we would do a powdered Kava for a couple of reasons - the concentrated form we are using tastes terrible and the FDA and insurance companies would probably have a huge issue with offering concentrated Kava in bulk form because of the possibility of people messing up their dosing.
We have considered a Nitrosigine for awhile; the issue is that they will not allow a company to name the product Nitrosigine or Nitrosigine XT or something like that. So it really limits the marketability of it bc people seeing the name wouldn't automatically know its Nitrosigine. That's why it keeps getting pushed back on the priority list.
What type formula for use with morning coffee do you have in mind?
As for Theanine, there will likely be formulas coming from us that do have it in there and some that don't. As much as it isn't liked by some on here, it is one of the most well-researched nootropics available and also sales wise, one of the most popular with many of the nootropic sites.
Pcakes
New member
Really excited for the Kava supplement. Used to make kavaritas all the time with the micronized powder.
sns8778
Board Sponsor
Thank you. I'm glad you're excited for it. Always feel free to let me know anything else that you'd like to see from us as well.
ELROCK
Well-known member
Cool. I am sitting at a kava bar right now drinking some kava and a kratom tea. Very relaxing.
Iwilleattuna
Well-known member
What happened to noopept?
Ape McGrapes
Well-known member
Not compliant with DSHE so SS won't produce it anymore.
Ape McGrapes
Well-known member
Keep an eye out for an unrelated PM. I do howver, have some questions about the new Kava product, but I'll run em by you before I post anything.however,
EDIT: Still waiting on a caffeine free Thermagize XT. Something I can stack with Focus XT.
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sns8778
Board Sponsor
I have but not for nootropic purposes. I had actually looked into it for helping with eye pressure as related to glaucoma and some eyedrop medications because I have some issues with my eyelids that require me to be on some drops from time to time.
I'll be glad to look into this more. Have you tried it?
sns8778
Board Sponsor
Weird situation on that one. A lot of companies stopped making it thinking the FDA may take action on it, then some started back again.
sns8778
Board Sponsor
I haven't gotten a pm from you; I'll be on the lookout but may not be on a lot this weekend.
The thing about caffeine free stimulant based products is that most of the market wants caffeine in them. I agree that I do like the idea of a stim product without caffeine so I can drink whatever I want a long with it. But most people at that point just buy a total stim free. So its kind of a matter of what I (and you) would like versus what would probably actually sell haha
mavup
Member
Interesting, it does seem to have widespread effects, but I hadn’t seen anything about it for eye health.
I got 10g of powder that I’ve been using for the last week or two and it’s made its way to the top tier of anxiolytics compounds for me - and I’ve tried it all. It’s a bit pricey, but worth it.
it’s a GABA-A PAM at the benzodiazepine site (as well as non-benzodiazepine sites, potentially), and also may have some interactions with TrkB/BDNF pathway. It displays selectivity for the a2 and a3 containing subtypes of the GABA-A receptor, and the a2 subunits are particularly important for anxiety (also found primarily in the hippocampus and forebrain). α3 subunits are also associated with anxiolytics effects without sedation.
it has high permeability but low solubility, so bioavailability is only around 13-23% I believe. In one human study it was dosed at 200, 400, 600, and 800mg and 600mg seemed to be the best and 800mg actually dropped off quite a bit. You can feel it at 250mg, but closer to 500 is a lot better. I haven’t tried 600 but will based on that study.
it goes well with a lot of other compounds, too.
from my experience so far it’s a neat compound and is effective for what I am looking for despite the lower bioavailability.
sns8778
Board Sponsor
Thank you for the details and insight. It does have very good potential benefits for people with glaucoma and other eye pressure related issues.
I'm seeing it most commonly at 250 mg. capsules; which is interesting being that you said the studied dosages were 200, 400, 600, etc. as I would have expected to see it moreso at a 200 mg. or 300 mg. dose.
Since you're interested in this, if you don't mind me asking a favor, when/if you have time, could you pm or email me some links to studied dosages if you come across them. I'd be curious to see if the studied dosages on the glaucoma benefits were the same as the anti anxiety ones. We could then take that information and figure out our dosage.
I'm just swamped right now, but if you have the time and don't mind helping with that, I'd be glad to try to source the raw materials and as long as it makes sense price wise, we could give it a try as a small run and see if people are interested and I'll be glad to send you a free bottle for helping
mavup
Member
That’s very generous, I would be happy to PM you when I get home and can access them from my computer!Thank you for the details and insight. It does have very good potential benefits for people with glaucoma and other eye pressure related issues.
I'm seeing it most commonly at 250 mg. capsules; which is interesting being that you said the studied dosages were 200, 400, 600, etc. as I would have expected to see it moreso at a 200 mg. or 300 mg. dose.
Since you're interested in this, if you don't mind me asking a favor, when/if you have time, could you pm or email me some links to studied dosages if you come across them. I'd be curious to see if the studied dosages on the glaucoma benefits were the same as the anti anxiety ones. We could then take that information and figure out our dosage.
I'm just swamped right now, but if you have the time and don't mind helping with that, I'd be glad to try to source the raw materials and as long as it makes sense price wise, we could give it a try as a small run and see if people are interested and I'll be glad to send you a free bottle for helping
I will say I wasn’t clear on the studied doses of between 200-800mg; that was a pharmacokinetic study in humans, I don’t believe it looked at efficacy. I may have been extrapolating based on my own experiences and other research. There was a less than dose dependent increase in Cmax, which was highest in the 600mg group, and my personal experience was in line with how I perceived the effects at 200 vs. 500mg. Anyway, I’ll still send you the links I have saved for baicalein in human subjects, though I think they are all pharmacokinetic studies. I’m not sure there are efficacy studies for anxiety/stress in human subjects but I could be wrong.
I absolutely feel an effect at 250mg and I’ve read other reports of people saying similar things, I just may have to take more to get the level of effect I want. I’m sure you’ll see in the research but the PK seem to be heavily dependent on intestinal UGT; in rats baicalein isn’t even detectable 20 minutes after administration. I think it is the same in beagles, too, but seems to change in monkeys and from what I can see, in humans.
I think 250mg is a reasonable dose in a capsule or tablet to give flexibility. The product I am using recommends 250mg 2-3x per day. That seems to be the norm for baicalein, as well as the anecdotally less potent baicalin. Anyway, you’re the expert there so I’m curious to see what you decide on if you go that route
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sns8778
Board Sponsor
That’s very generous, I would be happy to PM you when I get home and can access them from my computer!
I will say I wasn’t clear on the studied doses of between 200-800mg; that was a pharmacokinetic study in humans, I don’t believe it looked at efficacy. I may have been extrapolating based on my own experiences and other research. There was a less than dose dependent increase in Cmax, which was highest in the 600mg group, and my personal experience was in line with how I perceived the effects at 200 vs. 500mg. Anyway, I’ll still send you the links I have saved for baicalein in human subjects, though I think they are all pharmacokinetic studies. I’m not sure there are efficacy studies for anxiety/stress in human subjects but I could be wrong.
I absolutely feel an effect at 250mg and I’ve read other reports of people saying similar things, I just may have to take more to get the level of effect I want. I’m sure you’ll see in the research but the PK seem to be heavily dependent on intestinal UGT; in rats baicalein isn’t even detectable 20 minutes after administration. I think it is the same in beagles, too, but seems to change in monkeys and from what I can see, in humans.
I think 250mg is a reasonable dose in a capsule or tablet to give flexibility. The product I am using recommends 250mg 2-3x per day. That seems to be the norm for baicalein, as well as the anecdotally less potent baicalin. Anyway, you’re the expert there so I’m curious to see what you decide on if you go that route
Thank you, I really appreciate it.
I think sometimes with things like this in regards to the animal studies, there's no way to know how well it translates over to people except for just honest real world feedback.
I also need to look into the difference between Baicalein and Baicalin and see the difference in results and feedback, pricing, and raw material availability. I'm surprised not to see Baicalein available from any sources that I really trust so I need to look into if there is an issue on the raw material side of things that could be a reason why for that.
JKVol
Well-known member
I’m with you. I’m interested in a energy, feel good, motivation type product thats not a vasoconstrictor. I take a little bit of Kratom every day but I’d rather do that than load up on stims.
JKVol
Well-known member
I went though a who bottle. Tried several different intake options and never got anything out of it except heavy sedation
sns8778
Board Sponsor
I've mentioned a few times that I'm not going to give concrete ETA's on anything right now. The products are in the production lineup with a lot of other new product releases but bringing out new products has to also be balanced with keeping existing products in stock. If just guessing, I'd say you'll see both by the end of January with Sabroxy being first, maybe by the end of the year.
JKVol
Well-known member
What’s Sabroxy?
sns8778
Board Sponsor
It's a nootropic ingredient. I'm doing a very detailed write up on it but don't have it completed yet. So in the meantime, here is just the things that made the highlights/supports list:
- Improved Focus
- Motivation
- Mental Energy (Cognitive Energy)
- Improved Cognitive Function
- Skin Health
- Respiratory Health
- Immune Support
- Neurogenesis (new neuron formation)
- Nootropic, Longevity, and Anti-Aging Benefits
There aren't many Sabroxy products available at the moment and the one's that I've seen (no disrespect intended) I feel are very underdosed.
Btw.... your post count just hit 666 - reply or post something haha
JKVol
Well-known member
Oh goodness… that last part, yikes. Glad you seen that.
sns8778
Board Sponsor
Ha. Mission accomplished. You are now at post # 667. (was looking for a wiping sweat from forehead emoji but couldn't find one haha).
sns8778
Board Sponsor
What dosage are you using and what are you seeing out of it?
Beau
Well-known member
Here is what I have started with/am currently using:
250 Mg Uridine Monophosphate
3 Gr Fish Oil
150 Mg Alpha-GPC
125 Mg Citicholine
125 Mg DMAE L-Bitatrate
100 Mg Phosphatidylserine
25 Mg Phosphatidylcholine
2.5 Mg Phosphatidylethanolamine
1.5 Mg Phosphatidylinositol
Generally, I seem to be "brighter" mentally and my sleep seems better. I've not taken it long enough to be sure this isn't placebo effect, but I don't think it is.
Your thoughts on the combination?
sns8778
Board Sponsor
I had thought about it but the times I mentioned it no one seemed interested and they don't seem to sell well.
If enough people are interested, I'd be glad to.
sns8778
Board Sponsor
You are at or close to the ratio of Alpha GPC to Citicoline that I like and that I'm considering using in an upcoming product.
I prefer higher on DMAE - 200 to 400 mg. per day. I normally get at least 200 mg. bc I usually drink at least 1 serving of Focus XT daily and that's what it has in there.
I think Phosphatidylserine is one of those ingredients that seems to work great for a lot of people but not for me. That's not to knock the ingredient at all - I realize its a me thing on this one and it just doesn't seem to do much for me.
Beau
Well-known member
I have some additional DMAE powder. I may try to bump it up based on your thoughts (which I very much appreciate).
sns8778
Board Sponsor
I think you'd be pleased with it. I think its a very underrated nootropic when used daily. It's not one of the ones that make the huge dramatic difference in one dose but I think it really has a nice subtle consistent effect when used regularly.
And no problem at all. I'm glad to help any way that I can.
sns8778
Board Sponsor
I really enjoy the subject of natural nootropics.
A lot of times people get so caught up in the illegal nootropics that they forget or overlook that a lot of great natural options exist. And in a lot of cases, even the stronger illegal ones don't work nearly as well if you don't have your foundation bases covered. A great example of that is that Focus XT is basically the perfect nootropic base for almost any of the racetams.
rascal14
Well-known member
A good sedation like relaxed or just time for bed?
rascal14
Well-known member
Not necessarily nootropic, but maybe, I know people love CBD but I never got anything from it personally, even from hemp flower.
I was looking into delta 8, but have bad reactions to delta 9 and concluded the effects were too similar for me to want to try it at this point.
I have seen some on CBG.. does anyone have thoughts or experience on this? Maybe a full spectrum CBD/CBG supplement would be an option?
I was looking into delta 8, but have bad reactions to delta 9 and concluded the effects were too similar for me to want to try it at this point.
I have seen some on CBG.. does anyone have thoughts or experience on this? Maybe a full spectrum CBD/CBG supplement would be an option?
JKVol
Well-known member
“I cannot keep my eyes open” sedation
sns8778
Board Sponsor
If we do anything with CBD, it would likely be a completely separate line devoted just to CBD. I've thought about it, but the market is so saturated.
rascal14
Well-known member
That is true, incredibly saturated.
sns8778
Board Sponsor
I have some really cool ideas for CBD formulas if we were to do that. That's one thing I noticed is that a lot of the CBD formulas on the market are really not very well done - basically just like okay, here's CBD with a couple other ingredients thrown in, like they're relying completely on the CBD to do all the work.
ValiantThor08
Board Sponsor
Anesthesia
JKVol
Well-known member
I picked up a bottle of this from a popular noot store just to give it a try. If the dosage is legit, what’s a good starting point to add on to my caffeine, Bronkaid cocktail?