Exemestane solubility?

UNX

Member
I have some raw exemestane powder. I want to make a solution to dose it more accurately.
What's the best solvent I can use? I know it's not soluble in polar solvents like water or DMSO. It's soluble in methanol, but I want a solvent that won't kill me. In some oil solubility is low, like olive oil. I have to try in ethanol yet.
 
UNX said:
I have some raw exemestane powder. I want to make a solution to dose it more accurately.
What's the best solvent I can use? I know it's not soluble in polar solvents like water or DMSO. It's soluble in methanol, but I want a solvent that won't kill me. In some oil solubility is low, like olive oil. I have to try in ethanol yet.
Click to expand...


I'd try Ethanol.
 
Well, I did a quick test with ethanol and works, now I have to get some food grade ethanol to see if I can achieve a 50 mg/ml solution.
 
UNX said:
Well, I did a quick test with ethanol and works, now I have to get some food grade ethanol to see if I can achieve a 50 mg/ml solution.
Click to expand...


I know stores that carry that substance.
:)
 
@Renew1 I just distilled denaturated ethanol and it seems to solve fine up to 25 mg/ml.

@suavmcgauv I read about PEG6000 in a paper, maybe it's worth it because I have a lot of exemestane.
 
UNX said:
@Renew1 I just distilled denaturated ethanol and it seems to solve fine up to 25 mg/ml.

@suavmcgauv I read about PEG6000 in a paper, maybe it's worth it because I have a lot of exemestane.
Click to expand...

Well ... that works.
Personally I'd have just grabbed a drinkable bottle off the store shelf.
:)
 
Renew1 said:
Well ... that works.
Personally I'd have just grabbed a drinkable bottle off the store shelf.
:)
Click to expand...

Yes, but I guess the higher the alcohol content, the higher the solubility. Anyway, I'll try to get food grade alcohol just in case there's some methanol contamination.
 
You must log in or register to reply here.
Back
Top