Interesting. Never heard abput 8 on / 4 off for mk677. Always thought it is better to just run it continuously.
can you post a link to the study where it is confirmed that igf1 shoots up in the first week? I thought it took 2 weeks for a noticeable increase in igf 1.
I don't know if there are any clinical trials measuring IGF-1 concentrations after 7 days (I don't remember, as it's been years since I read the literature), but at this point I couldn't care less about clinical trials.
The reason you never heard of an 8 ON/4 OFF protocol is because I am the one first one to recommend that particular protocol. However, I am NOT the first one to recommend short cycles as a result of MK causing densentization. There have been several people before me who have recommended cycling MK for short spurts--for the same reasons I mention here. Scott Stevenson recommended short cycles at least a year ago, if not a few years ago. I initially disagreed with him, but it turns out he was correct.
My recommendation is based on one indisputable fact--MK causes quick and signficant sensitization, with GH production falling rapidly within a week (or so) of regular use.
Furthermore, it doesn't take 2 weeks for IGF-1 levels to rise in response to elevations in GH. I don't know who told you that nonsense, but that's exactly what it is. Nonsense. IGF-1 levels rise in response to elevations in GH...and it takes place immediately. The body doesn't wait to start producing IGF-1. Furthermore, the higher GH levels rise, the more IGF-1 conversion takes place.
Being that MK-677 is at its most powerful (from GH elevating standpoint) during the first week (with rapid and significant desensitization occuring afterwards), it doesn't make sense to run MK for weeks on end. GH production with MK is potentially several times greater during week 1, than it is on say, week 4. I have seen numerous labs showing elevations in IGF-1 equivalent to 8-10 iu of GH after just 1 week of use (the typical increase ranges from 5-8 iu).
Likewise, labs also show significant decreases in IGF-1 levels after several weeks of use, leaving the user with IGF-1 levels equivalent to just 2-3 iu of GH. You will maintain your IGF-1 levels from that point forward, but it makes no sense to continue using a product that causes such significant desensitization when you can just take some time off and experience greater overall GH/IGF-1 production.
The bottom line: It is NOT better to run MK-677 continuously...unless you want to waste money and experience less overall GH/IGF-1 production. We have seen more than enough labs at this point, in combination with clinical research, to conclude that daily use is not ideal. I SELL MK-677. I receive zero benefit by telling people to follow an 8 ON/4 OFF protocol. When people do that, I LOSE money. MK has been in use for many years now...and the amount of labs/research conducted is immense. Anyone who does their due diligence on the research front will readily see that conventional protocols simply aren't ideal when the goal is maximal GH/IGF-1 output.