2 grams glycine, 2 grams lysine, 650mg agmatine and 450mg magnesium seems to help me sleep, deeper sleep and feel well rested in the mornings. I am thankful this simple stack works for me most of the time because it is incredibly inexpensive.
Glycine is something I wanted to love because I read the studies and anecdotal evidence, but it never did anything for me. Tried a couple of brands, played with dosing, and nothing.
(Now I'd like to go read all the studues etc but if someone can post the ones worth reading/that have worthwhile info in them on here that would be great. Dealing w too much other shyt atm. Tyia. )
I use it for the insulin sensitivity with high carb meals and more before bed on an empty stomach with my magnesium glycinate. I don’t feel as bad from a carbage meal when I use 3-5g with it. That alone makes it worth it and it’s so cheap, I just use it because of the evidence to support it is enough for me.
I don't believe glycine works as they claim. I have never seen anything that shows glycine working as a switch between sympathetic and parasympathetic control as they claim in this text, "Being an amino acid neurotransmitter inhibiting the central nervous system, an increased intake of glycine favors a more rapid transition from the active state of the "adrenal" sympathetic nervous system , which favors the surge of cortisol, to that of a "parasympathetic" nervous state , which instead it promotes calmness and global recovery (as well as digestion and / or absorption)."
Sure, it has activity in a lot of inhibitory circuits, but it's also a co-factor for excitatory NMDA synapses. The context of what part of the nervous system it is working in is important.
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